期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9
卷 9, 期 -, 页码 219-238出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-012513-104653
关键词
granuloma; Trojan horse; disease tolerance; fungal immunity; intracellular pathogen; C. neoformans killing
类别
资金
- NCI NIH HHS [P30 CA013330, P30CA013330] Funding Source: Medline
- NHLBI NIH HHS [R01 HL059842, HL059842-3] Funding Source: Medline
- NIAID NIH HHS [R37 AI033142, AI033142, R01 AI033142] Funding Source: Medline
- PHS HHS [A1052733, A1033774] Funding Source: Medline
Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological studies of human populations show a high prevalence of human infection, which rarely progresses to disease in immunocompetent hosts. However, decreased host immunity places individuals at high risk for cryptococcal disease. The disease can result from acute infection or reactivation of latent infection, in which yeasts within granulomas and host macrophages emerge to cause disease. In this review, we summarize what is known about the cellular recognition, ingestion, and killing of C. neoformans and discuss the unique and remarkable features of its intracellular life, including the proposed mechanisms for fungal persistence and killing in phagocytic cells.
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