标题
Molecular Pathogenesis of Ewing Sarcoma: New Therapeutic and Transcriptional Targets
作者
关键词
-
出版物
Annual Review of Pathology-Mechanisms of Disease
Volume 7, Issue 1, Pages 145-159
出版商
Annual Reviews
发表日期
2011-03-02
DOI
10.1146/annurev-pathol-011110-130237
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Racial Differences in the Incidence of Mesenchymal Tumors Associated with EWSR1 Translocation
- (2011) J. Worch et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening
- (2011) Patrick J. Grohar et al. JNCI-Journal of the National Cancer Institute
- An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases A and B
- (2011) G. E. Winter et al. MOLECULAR CANCER THERAPEUTICS
- A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs
- (2011) E L McKinsey et al. ONCOGENE
- Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
- (2011) D. A. Solomon et al. SCIENCE
- Promiscuous partnerships in Ewing's sarcoma
- (2011) Savita Sankar et al. Cancer Genetics
- Function of EWS-POU5F1 in Sarcomagenesis and Tumor Cell Maintenance
- (2010) Takashi Fujino et al. AMERICAN JOURNAL OF PATHOLOGY
- Biological Rationale and Current Clinical Experience With Anti-Insulin-Like Growth Factor 1 Receptor Monoclonal Antibodies in Treating Sarcoma
- (2010) David Olmos et al. CANCER JOURNAL
- A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
- (2010) Jeffrey D. Hancock et al. CELL CYCLE
- A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors
- (2010) R. Kurzrock et al. CLINICAL CANCER RESEARCH
- EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells
- (2010) N. Riggi et al. GENES & DEVELOPMENT
- EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene
- (2010) Cristina R. Antonescu et al. GENES CHROMOSOMES & CANCER
- The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation
- (2010) Xiaodong Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Impact ofEWS-ETSFusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results From the Cooperative Euro-E.W.I.N.G. 99 Trial
- (2010) Marie-Cecile Le Deley et al. JOURNAL OF CLINICAL ONCOLOGY
- Current Treatment Protocols Have Eliminated the Prognostic Advantage of Type 1 Fusions in Ewing Sarcoma: A Report From the Children's Oncology Group
- (2010) John A. van Doorninck et al. JOURNAL OF CLINICAL ONCOLOGY
- Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer
- (2010) Robert G. Maki JOURNAL OF CLINICAL ONCOLOGY
- Ewing's sarcoma
- (2010) Naomi J Balamuth et al. LANCET ONCOLOGY
- Nuclear reprogramming to a pluripotent state by three approaches
- (2010) Shinya Yamanaka et al. NATURE
- De novo motif identification improves the accuracy of predicting transcription factor binding sites in ChIP-Seq data analysis
- (2010) Valentina Boeva et al. NUCLEIC ACIDS RESEARCH
- Downstream EWS/FLI1 - upstream Ewing's sarcoma
- (2010) Heinrich Kovar Genome Medicine
- Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target
- (2009) D Herrero-Martín et al. BRITISH JOURNAL OF CANCER
- Review of Mesenchymal Stem Cells and Tumors: Executioner or Coconspirator?
- (2009) Bing Feng et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Ewing sarcoma–peripheral neuroectodermal tumor of the kidney with a FUS–ERG fusion transcript
- (2009) Thomas Berg et al. CANCER GENETICS AND CYTOGENETICS
- EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma
- (2009) M. Kinsey et al. CANCER RESEARCH
- Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?
- (2009) J. L. Ordonez et al. CANCER RESEARCH
- The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes β-catenin/TCF-mediated transcription
- (2009) Diego Navarro et al. CARCINOGENESIS
- The NFATc2 Gene Is Involved in a Novel Cloned Translocation in a Ewing Sarcoma Variant That Couples Its Function in Immunology to Oncology
- (2009) K. Szuhai et al. CLINICAL CANCER RESEARCH
- GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein
- (2009) Elspeth Beauchamp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1
- (2009) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- Peripheral Primitive Neuroectodermal Tumour in a Lumbar Vertebra and the Liver of a Dromedary Camel (Camelus dromedarius)
- (2009) R. Weiss et al. JOURNAL OF COMPARATIVE PATHOLOGY
- IGF-1R targeted treatment of sarcoma
- (2009) Jeffrey A Toretsky et al. LANCET ONCOLOGY
- Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
- (2009) David Olmos et al. LANCET ONCOLOGY
- Forcing cells to change lineages
- (2009) Thomas Graf et al. NATURE
- A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
- (2009) Hayriye V Erkizan et al. NATURE MEDICINE
- GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
- (2009) W Luo et al. ONCOGENE
- O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma
- (2009) R Bachmaier et al. ONCOGENE
- Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
- (2009) Nino Keshelava et al. PEDIATRIC BLOOD & CANCER
- The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function
- (2009) Noëlle Guillon et al. PLoS One
- A Molecular Function Map of Ewing's Sarcoma
- (2009) Maximilian Kauer et al. PLoS One
- GLI1 Is a Central Mediator of EWS/FLI1 Signaling in Ewing Tumors
- (2009) Jay Joo et al. PLoS One
- EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
- (2009) G. H. S. Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of IGF-IR inhibitors in pediatric sarcomas
- (2009) E. Anders Kolb et al. Current Oncology Reports
- EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma
- (2008) J. Ban et al. CANCER RESEARCH
- EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells
- (2008) N. Riggi et al. CANCER RESEARCH
- POU5F1, encoding a key regulator of stem cell pluripotency, is fused toEWSR1in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands
- (2008) E Möller et al. JOURNAL OF PATHOLOGY
- DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells
- (2008) E García-Aragoncillo et al. ONCOGENE
- Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: A report from the Children's Oncology Group
- (2008) Steven G. DuBois et al. PEDIATRIC BLOOD & CANCER
- EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma
- (2008) Leah A. Owen et al. PLoS One
- IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells
- (2008) Luisa Cironi et al. PLoS One
- Microsatellites as EWS/FLI response elements in Ewing's sarcoma
- (2008) K. Gangwal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started