Iron Homeostasis and the Inflammatory Response

Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium

(2014) H. Saiga et al.   JOURNAL OF IMMUNOLOGY

Attenuated Inflammatory Responses in Hemochromatosis Reveal a Role for Iron in the Regulation of Macrophage Cytokine Translation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Regulation of Hepcidin and Iron-Overload Disease

(2009) Pauline L. Lee et al.   Annual Review of Pathology-Mechanisms of Disease

Siderocalins: siderophore-binding proteins of the innate immune system

(2009) Matthew C. Clifton et al.   BIOMETALS

Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction

(2009) Suman Deb et al.   BIOMETALS

Hepcidin, the hormone of iron metabolism, is bound specifically to  -2-macroglobulin in blood

(2009) G. Peslova et al.   BLOOD

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi

(2009) C. L. Koening et al.   BLOOD

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

(2009) M. Nairz et al.   BLOOD

Role of iron in carcinogenesis: Cancer as a ferrotoxic disease

(2009) Shinya Toyokuni   CANCER SCIENCE

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells

(2009) P. Matak et al.   HAEMATOLOGICA

CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells

(2009) Yaohe Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ

(2009) Fatoumata B. Sow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A general map of iron metabolism and tissue-specific subnetworks

(2009) Valerie Hower et al.   Molecular BioSystems

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity

(2009) Susana J. Oliveira et al.   PLoS One

Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors

(2009) Melanie Volke et al.   PLoS One

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

(2009) S. Soe-Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Iron Sequestration and Anemia of Inflammation

(2009) Tomas Ganz et al.   SEMINARS IN HEMATOLOGY

Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron

(2008) Daniel F. Wallace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron metabolism in the anemia of chronic disease

(2008) Günter Weiss   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

(2008) D.R. Richardson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

(2008) J. Truksa et al.   BLOOD

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP 

(2008) J. P. Pinto et al.   BLOOD

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children

(2008) S. H. Atkinson et al.   BLOOD

Iron depletion limits intracellular bacterial growth in macrophages

(2008) P. N. Paradkar et al.   BLOOD

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Nramp1 drives an accelerated inflammatory response duringSalmonella-induced colitis in mice

(2008) Yanet Valdez et al.   CELLULAR MICROBIOLOGY

Epidemiology of Invasive Mold Infections in Allogeneic Stem Cell Transplant Recipients: Biological Risk Factors for Infection According to Time after Transplantation

(2008) Carol Garcia‐Vidal et al.   CLINICAL INFECTIOUS DISEASES

Interferon‐γ limits the availability of iron for intramacrophageSalmonella typhimurium

(2008) Manfred Nairz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Hereditary Hemochromatosis Protein, HFE, Inhibits Iron Uptake via Down-regulation of Zip14 in HepG2 Cells

(2008) Junwei Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals

(2008) Lorenza Tacchini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Susceptibility toPlasmodium falciparumInfection in Pregnant Women with Iron Deficiency

(2008) Edward R. Kabyemela et al.   JOURNAL OF INFECTIOUS DISEASES

Iron Metabolism, Malaria, and Other Infections: What Is All the Fuss About?

(2008) Andrew M. Prentice   JOURNAL OF NUTRITION

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle

(2008) A. K. Sendamarai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD