期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 72
卷 72, 期 -, 页码 141-161出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-090817-062607
关键词
small RNA; sRNA; sRNA characteristics; regulatory mechanisms; definition of sRNAs; emerging technologies; RNA sequencing
资金
- CIHR Funding Source: Medline
The first report of trans-acting RNA-based regulation in bacterial cells dates back to 1984. Subsequent studies in diverse bacteria unraveled shared properties of trans-acting small regulatory RNAs, forming a clear definition of these molecules. These shared characteristics have been used extensively to identify new smallRNAs(sRNAs) and their interactomes. Recently however, emerging technologies able to resolve RNA-RNA interactions have identified new types of regulatory RNAs. In this review, we present a broader definition of trans-acting sRNA regulators and discuss their newly discovered intrinsic characteristics.
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