期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 67
卷 67, 期 -, 页码 113-139出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092412-155756
关键词
sigma; TBP; TFIIB; activation; promoter
类别
资金
- Intramural NIH HHS Funding Source: Medline
Multisubunit RNA polymerases are complex protein machines that require a specificity factor for the recognition of a specific transcription start site. Although bacterial sigma factors are thought to be quite different from the specificity factors employed in higher organisms, a comparison of the sigma/RNA polymerase structures with recent structures of eukaryotic Pol II together with TFIIB highlights significant functional similarities. Other work reveals that both bacterial and eukaryotic promoters are composed of modular elements that are used in different combinations. Bacteria, archaea, and eukaryotes also utilize similar strategies to alter core promoter specificity, from specificity factor exchange to the employment of activators that bind close to or overlap core promoter sequences, directing the transcriptional machinery to a new start site. Here we examine the details of core promoter recognition in bacteria that reveal the transcriptional similarities throughout biology.
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