期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 66
卷 66, 期 -, 页码 153-176出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092611-150051
关键词
neuroinvasion; neurotropism; neurovirulence; axon; neuron; sensory ganglion
类别
资金
- NIAID NIH HHS [R01 AI056346] Funding Source: Medline
Herpes simplex virus, varicella zoster virus, and pseudorabies virus are neurotropic pathogens of the Alphaherpesvirinae subfamily of the Herpesviridae. These viruses efficiently invade the peripheral nervous system and establish lifelong latency in neurons resident in peripheral ganglia. Primary and recurrent infections cycle virus particles between neurons and the peripheral tissues they innervate. This remarkable cycle of infection is the topic of this review. In addition, some of the distinguishing hallmarks of the infections caused by these viruses are evaluated in terms of their underlying similarities.
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