Article
Nanoscience & Nanotechnology
Hye Jin Cho, Eunyoung Kang, Seonghoon Kim, D. ChangMo Yang, Joohan Nam, Eunji Jin, Jinhyu Lee, Wonyoung Choe
Summary: In this study, a water-stable Zr-based porphyrinic metal-organic framework (MOF), PCN-224, was used for the targeted adsorption of nonsteroidal anti-inflammatory drugs. The results showed high removal efficiencies for NPX and IBP, but lower efficiency for SMX. The strong interaction between the carboxylic acid functional groups in drugs and the open metal sites of PCN-224 was found to be responsible for the high adsorption capacity.
ACS APPLIED NANO MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Xie-Yuan Leng, Chang-Ning Liu, Shi-Chan Wang, Hao-Dong Peng, De-Guang Wang, Hai-Feng Pan
Summary: This study conducted a systematic review and meta-analysis to compare the effectiveness and safety between NSAIDs and opioids in the treatment of acute renal colic. The results showed no significant differences in various outcomes between these two treatment options, but patients treated with NSAIDs experienced fewer side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Bofei Li, Ka Shing Cheung, Ian Yu-Hong Wong, Wai Keung Leung, Simon Law
Summary: The study found that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) did not reduce the risk of gastric cancer in patients who underwent Helicobacter pylori eradication, suggesting that the chemopreventive effect of NA-NSAIDs observed in prior studies may have been confounded by immortal time bias.
Review
Oncology
Peri Newman, Joshua Muscat
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) have the potential to prevent the recurrence of adenomatous polyps and colon cancer, making them of interest as cancer prevention agents. However, their use in individuals with inflammatory bowel disease is complicated by the risk of bowel damage. This review summarizes the medical opinions on this topic and suggests future research areas.
Article
Chemistry, Multidisciplinary
Marta S. Krawczyk, Irena Majerz
Summary: This study explores the synthesis of complexes of fenamic, flufenamic, mefenamic, and tolfenamic acids with ethacridine lactate, and characterizes them using X-ray diffraction. The formation of hydrogen bonds and other weak interactions is analyzed using Quantum Theory of Atoms in Molecules and noncovalent interaction approaches. The presence of solvent molecules in crystals also contributes to the formation of interaction networks.
CRYSTAL GROWTH & DESIGN
(2022)
Review
Environmental Sciences
Shane R. de Solla, Laura E. King, Eve A. M. Gilroy
Summary: Abnormally thin eggshells can reduce avian reproductive success and have caused population declines. Non-steroidal anti-inflammatory drugs (NSAIDs) may impair eggshell development, and their effects have been observed in scavenging birds. The study discusses the environmental exposure to NSAIDs, the process of eggshell formation, and the mechanisms by which NSAIDs affect eggshell thickness. It highlights the potential hazard of NSAIDs in the environment for wild bird reproduction.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Oncology
Jadwiga Maniewska, Dagmara Jezewska
Summary: The study highlights a correlation between long-term use of NSAIDs and decreased risk of colorectal cancer, indicating a potential change in treatment approaches for the disease. The main molecular mechanism of action of NSAIDs is believed to be the suppression of prostaglandin E-2 synthesis via cyclooxygenase-2 inhibition, leading to reduced tumor cell proliferation.
Review
Pharmacology & Pharmacy
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen
Summary: Cyclooxygenases play a vital role in inflammation, but currently used anti-inflammatory drugs have associated adverse effects. Researchers are searching for novel selective COX-2 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Surgery
Summary: This study aimed to investigate the relationship between early postoperative NSAID administration and postoperative AKI and anastomotic leak. The results showed that early use of NSAIDs in selected patients following major gastrointestinal surgery is safe.
Article
Microbiology
Anna Pawelczyk, Rafal Nowak, Monika Gazecka, Anna Jelinska, Lucjusz Zaprutko, Pawel Zmora
Summary: The study explores the potential of combining cannabidiol (CBD) and non-steroidal anti-inflammatory drugs (NSAIDs) as novel antiviral dual-target agents against SARS-CoV-2/COVID-19. Chemical modifications were made to CBD to enhance its activity against the virus. The results showed promising antiviral activity against SARS-CoV-1 and SARS-CoV-2, suggesting a potential therapeutic role for these compounds in treating emerging coronavirus infections.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Review
Medicine, General & Internal
Gowhar Rashid, Nihad Ashraf Khan, Deena Elsori, Andleeb Rehman, Haleema Tanzeelah, Haleema Ahmad, Humaira Maryam, Amaan Rais, Mohd Salik Usmani, Asaad Ma Babker, Mohammad Azhar Kamal, Wael Hafez
Summary: Colorectal cancer is caused by mutations in large intestinal epithelial cells and can be detected early through biomarkers such as KRAS and ctDNA/cfDNA. While colonoscopy is the most common invasive method for diagnosing CRC, non-invasive techniques like molecular analysis of breath, urine, blood, and stool can also be used for early detection. NSAIDs have been found to have a chemopreventive impact on CRC by inhibiting cyclooxygenase enzymes and causing apoptosis in CRC cells. This review paper explores the diversity of biomarkers and detection techniques for CRC, as well as the role of NSAIDs in chemoprevention.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jeffery S. Staab, Alexander L. Kolb, Ryan E. Tomlinson, Paola Divieti Pajevic, Ronald W. Matheny, Julie M. Hughes
Summary: There is mounting evidence suggesting that NSAIDs may inhibit new bone formation and increase risk of stress fractures, particularly in physically active populations like endurance athletes and military recruits. However, human trials evaluating the effects of NSAIDs on exercise and bone adaptation have been inconclusive. Further research is needed to address knowledge gaps and support guidelines for at-risk populations.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, General & Internal
Nattawat Klomjit, Patompong Ungprasert
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed drugs that inhibit COX enzyme, affecting prostaglandin production and causing various renal complications. AKI from NSAIDs is usually reversible after discontinuation, emphasizing the importance of avoiding NSAIDs in high-risk patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Saghir Ahmad, Muhammad Abdul Qadir, Mahmood Ahmed, Muhammad Imran, Numan Yousaf, Asnuzilawati Asari, Abdul Hameed, Muhammad Muddassar
Summary: Conjugates of existing drugs are being used to explore new modes of action and reduce side effects in medicinal chemistry. In this study, new conjugates involving acetylsalicylic acid and sulfa drugs were synthesized and their activities against enzymes in various pathological conditions were assessed. The results showed that the conjugates effectively inhibited cyclooxygenase-2 (COX-2), urease enzymes, and displayed strong anti-inflammatory potential.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
