Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Hollie A. L. Burton, Luise Pickenhan, Claire Carson, Paul Salkovskis, Fiona Alderdice
Summary: This review synthesized evidence on the experiences of maternity care and mental health care for women with Obsessive Compulsive Disorder (OCD) during pregnancy and postpartum. The findings revealed three descriptive themes: experiences of barriers to treatment and care, experiences of treatment/care decision making, and experiences of treatment and care. Three analytic themes were also identified, which demonstrated tensions in balancing the health and safety of the baby and the mother, as well as the perception of a normal perinatal experience. The review highlighted significant gaps in the literature, particularly regarding maternity and pharmacological care experiences. Balancing these tensions is crucial to ensure that women with OCD receive the necessary care.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Irena Smaga, Malgorzata Frankowska, Malgorzata Filip
Summary: N-acetylcysteine (NAC) is a well-known mucolytic agent that has shown beneficial effects on different psychiatric disorders. It exerts its effects through regulating neurotransmitters, oxidative balance, and inflammatory mediators. While preclinical studies have shown positive results, further research is needed to establish the clinical efficacy of NAC for psychiatric disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychology, Multidisciplinary
Liliana Dell'Osso, Benedetta Nardi, Chiara Bonelli, Davide Gravina, Francesca Benedetti, Luca Del Prete, Gabriele Massimetti, Giulia Amatori, Barbara Carpita, Ivan Mirko Cremone
Summary: Recent research emphasizes the importance of a dimensional perspective on mental disorders, particularly the conceptualization of an obsessive-compulsive spectrum. The current study aims to evaluate the psychometric characteristics of the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) questionnaire. The results demonstrate strong reliability and validity of the OBS-SV, showing significant correlations with other measures of obsessive-compulsive symptoms.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychiatry
Tamar C. Katz, Thanh Hoa Bui, Jennifer Worhach, Gabrielle Bogut, Kinga K. Tomczak
Summary: Tourettic OCD (TOCD) is a unique condition with overlapping symptoms of OCD and CTD. It is characterized by complex tic-like behaviors with compulsive and anxious features. TOCD is an intermediate neuropsychiatric disorder distinct from TS or OCD alone. The treatment of TOCD is complex and often resistant to treatment, requiring a combination of pharmacology and behavioral therapy.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Vera Nezgovorova, Casara Jean Ferretti, Stefano Pallanti, Eric Hollander
Summary: Exacerbation or new onset of OCD symptoms during COVID-19 is an understudied area. Increased proinflammatory immune response in COVID-19 patients may be associated with the onset of obsessive-compulsive symptoms, and targeted anti-cytokine treatments can help mitigate these symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
David E. Freedman, Margaret A. Richter
Summary: Through systematic search and analysis of literature, it was found that exercise is beneficial for OCD symptoms, but the effects vary among individuals, indicating the need for further research.
GENERAL HOSPITAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Giordano D'Urso, Alfonso Magliacano, Sayna Rotbei, Felice Iasevoli, Andrea de Bartolomeis, Alessio Botta
Summary: During the COVID-19 pandemic, there has been an increase in psychiatric disorders in the general population and severity of symptoms in psychiatric patients. Anxiety and depression symptoms were most commonly observed, especially during extended lockdowns. This study used supervised machine learning to predict the severity of psychiatric symptoms during the Italian lockdown. The results showed up to 92% accuracy in predicting depression, anxiety, and obsessive-compulsive symptoms based on demographic and clinical characteristics collected before the pandemic. This methodology can be used to predict psychiatric prognosis and support clinical decisions during large-scale lockdowns.
Article
Psychology, Clinical
Mao-Hsuan Huang, Chih-Ming Cheng, Shih-Jen Tsai, Ya-Mei Bai, Cheng-Ta Li, Wei-Chen Lin, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: The study found that first-degree relatives of patients with obsessive-compulsive disorder have a higher risk of major psychiatric disorders such as major depressive disorder, bipolar disorder, OCD, autism spectrum disorder, ADHD, and schizophrenia. Different familial relationships of first-degree relatives consistently had increased risks for these disorders, and a dose-dependent relationship was found between the number of OCD probands and the risk of each major psychiatric disorder.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Johanna Otte, Nathalie Schicktanz, Dorothee Bentz
Summary: The aim of this study was to investigate the change in obsessive-compulsive symptoms (OCSs) from before to during the COVID-19 pandemic within the Swiss general population, and to examine the possible relationship of OCSs to stress and anxiety. The results showed that OCSs significantly increased during the pandemic, particularly in the washing dimension. Self-reported stress and anxiety were weakly associated with the severity of OCSs. The study suggests that all individuals with OCSs should be considered as risk groups for symptom deterioration during a pandemic and when assessing its possible long-term effects.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Katalin Csigo
Summary: Obsessive-compulsive disorder (OCD) is a difficult-to-treat disorder with diverse symptoms. This study focuses on object relations theory to understand OCD symptoms, particularly the concept of the obsessive position. The study distinguishes between the obsessive ego-state and the realistic ego-state, proposing OCD as a disorder of personality and ego organization. The application of a modified psychoanalytic methodology is advocated, with a glimpse into a psychoanalytic therapy session with an OCD patient.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Yimeng Pan, Chuanyong Xu, Tingxin He, Zhen Wei, Carol A. Seger, Qi Chen, Ziwen Peng
Summary: Background：The relationship between cognitive function and psychopathological symptoms has been an important research field. Methods：This study used network analysis to construct networks of cognitive variables and OCD-related symptoms in patients with OCD and healthy controls. Results：The study highlighted the important role of variables such as obsession and IQ from a network perspective. Conclusions: These results deepen our understanding of the multivariate relationship between cognitive dysfunction and OCD symptoms and may promote the prediction and diagnosis of OCD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
