期刊
ANNUAL REVIEW OF MEDICINE, VOL 62, 2011
卷 62, 期 -, 页码 157-170出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-050409-103711
关键词
HIV; cancer; sub-Saharan Africa; Kaposi sarcoma; lymphoma; hepatocellular carcinoma
资金
- FIC NIH HHS [D43 TW009759] Funding Source: Medline
- NCI NIH HHS [D43 CA153720, R01 CA206466, P30 CA015704] Funding Source: Medline
- NIAID NIH HHS [P30 AI027757] Funding Source: Medline
Cancer is increasingly recognized as a complication of MT infection in both resource-rich and resource-limited areas. The traditional AIDS-defining cancers, including Kaposi sarcoma, cervical cancer, and non-Hodgkin lymphoma, have become common comorbidities afflicting HIV-positive individuals and lack adequate prevention and management options. Additionally, several non-AIDS-defining cancers have increased in incidence in resource-limited regions, including Hodgkin lymphoma, hepatocellular carcinoma, and lung cancer. This review outlines the epidemiology of HIV-associated malignancies in resource-poor and resource-rich areas, including the impact of highly active antiretroviral therapy on the incidence of these cancers. The pathogenesis of HIV-associated cancers is considered in relation to potential strategies for their prevention and treatment.
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