Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes

Cutting Edge: Developmental Stage-Specific Recruitment of Cohesin to CTCF Sites throughout Immunoglobulin Loci during B Lymphocyte Development

(2014) S. C. Degner et al.   JOURNAL OF IMMUNOLOGY

Immunostaining of modified histones defines high-level features of the human metaphase epigenome

(2011) Edith Terrenoire et al.   GENOME BIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not

(2010) A. G. Tsai et al.   BLOOD

Mechanisms of chromosomal rearrangement in the human genome

(2010) Albert G Tsai et al.   BMC GENOMICS

Origin of Chromosomal Translocations in Lymphoid Cancer

(2010) André Nussenzweig et al.   CELL

The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

(2010) Yanhong Ji et al.   CELL

Molecular biology of therapy-related leukaemias

(2010) Melanie Joannides et al.   Clinical & Translational Oncology

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATM-deficient thymic lymphoma is associated with aberranttcrdrearrangement and gene amplification

(2010) Shan Zha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathways for Double-strand Break Repair in Genetically Unstable Z-DNA-forming Sequences

(2010) Diem T. Kha et al.   JOURNAL OF MOLECULAR BIOLOGY

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

(2010) F. Rucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell type specificity of chromatin organization mediated by CTCF and cohesin

(2010) Chunhui Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region

(2009) Monica Gostissa et al.   NATURE

Mechanisms promoting translocations in editing and switching peripheral B cells

(2009) Jing H. Wang et al.   NATURE

Chromosomal location targets different MYC family gene members for oncogenic translocations

(2009) M. Gostissa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the translocation partner in protection against AID-dependent chromosomal translocations

(2009) M. Jankovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

(2009) R. Geisberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis

(2009) G. K. Mahowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma

(2009) S. Mathas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

(2009) Hwei-Ling Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation of the Philadelphia chromosome into therapy for CML

(2008) B. J. Druker   BLOOD

Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

(2008) Albert G. Tsai et al.   CELL

The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions

(2008) Suchit Jhunjhunwala et al.   CELL

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

(2008) Grace Teng et al.   IMMUNITY

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

Aberrant AID expression and human cancer development

(2008) Hiroyuki Marusawa   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites

(2008) Albert G. Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

(2008) Sonia Franco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fixing DNA breaks during class switch recombination: Figure 1.

(2008) Christopher J. Jolly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

(2008) Jing H. Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of class switch recombination and somatic mutation by AID phosphorylation

(2008) Kevin M. McBride et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells

(2008) Li Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

(2008) Gang Li et al.   MOLECULAR CELL

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

(2008) Simone Difilippantonio et al.   NATURE

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

(2008) Steven M. Yannone et al.   NUCLEIC ACIDS RESEARCH

Complementary functions of ATM and H2AX in development and suppression of genomic instability

(2008) S. Zha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE

Gene Regulation in the Third Dimension

(2008) J. Dekker   SCIENCE