The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

(2013) Massimo Bogliolo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural peculiarities of the (MHF1-MHF2)4octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study

(2013) Wenjia Wang et al.   FEBS LETTERS

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

(2013) Rebekka A. Schwab et al.   JOURNAL OF CELL BIOLOGY

FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions

(2013) Yucai Wang et al.   MOLECULAR CELL

Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex

(2013) Rachel Coulthard et al.   STRUCTURE

On the role of FAN1 in Fanconi anemia

(2012) J. P. Trujillo et al.   BLOOD

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

(2012) Y. Kim et al.   BLOOD

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway

(2012) A. M. Ali et al.   BLOOD

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

(2012) Tatsuya Nishino et al.   CELL

A prototypical Fanconi anemia pathway in lower eukaryotes?

(2012) Peter J. McHugh et al.   CELL CYCLE

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

The DNA translocase activity of FANCM protects stalled replication forks

(2012) Andrew N. Blackford et al.   HUMAN MOLECULAR GENETICS

Exome sequencing reveals a novel Fanconi group defined by XRCC2 mutation: Figure 1

(2012) Hanan E Shamseldin et al.   JOURNAL OF MEDICAL GENETICS

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

(2012) Zhijiang Yan et al.   MOLECULAR CELL

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Rev1 by the Fanconi anemia core complex

(2012) Hyungjin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase

(2012) Archana Sareen et al.   NUCLEIC ACIDS RESEARCH

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI

(2012) K. Sato et al.   NUCLEIC ACIDS RESEARCH

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

(2012) J. W. C. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FANCM Limits Meiotic Crossovers

(2012) W. Crismani et al.   SCIENCE

The structure of the FANCM–MHF complex reveals physical features for functional assembly

(2012) Yuyong Tao et al.   Nature Communications

How high are carrier frequencies of rare recessive syndromes? Contemporary estimates for Fanconi Anemia in the United States and Israel

(2011) Philip S. Rosenberg et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

X-linked VACTERL with hydrocephalus syndrome: Further delineation of the phenotype caused byFANCBmutations

(2011) Joanna McCauley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations

(2011) M. Castella et al.   BLOOD

Ubiquitylation and the Fanconi anemia pathway

(2011) Elizabeth Garner et al.   FEBS LETTERS

Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms

(2011) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

(2011) Charlotte Hodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

(2011) Ivan V Rosado et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

(2011) K. N. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

(2011) Woo Joo et al.   SCIENCE

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer

(2010) K. Somyajit et al.   CARCINOGENESIS

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

(2010) Liyi Geng et al.   JOURNAL OF CELL BIOLOGY

MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM

(2010) Thiyam Ramsing Singh et al.   MOLECULAR CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

(2010) Min Huang et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Ubiquitin signalling in DNA replication and repair

(2010) Helle D. Ulrich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The structure of the catalytic subunit FANCL of the Fanconi anemia core complex

(2010) Ambrose R Cole et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Convergence of Rad6/Rad18 and Fanconi Anemia Tumor Suppressor Pathways upon DNA Damage

(2010) Hwan Ki Park et al.   PLoS One

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

(2010) T. Liu et al.   SCIENCE

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Diagnosis of Fanconi anemia in patients with bone marrow failure

(2009) F. O. Pinto et al.   HAEMATOLOGICA

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M

(2009) Sietske T. Bakker et al.   HUMAN MOLECULAR GENETICS

FANCI Protein Binds to DNA and Interacts with FANCD2 to Recognize Branched Structures

(2009) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL

(2009) Simonne Longerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

(2009) J. K. Hicks et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCM: A Landing Pad for the Fanconi Anemia and Bloom's Syndrome Complexes

(2009) Patrizia Vinciguerra et al.   MOLECULAR CELL

Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination

(2009) Sabrina L. Andersen et al.   MOLECULAR CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

Fanconi anemia and its diagnosis

(2009) Arleen D. Auerbach   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

(2009) Ivan V. Rosado et al.   NUCLEIC ACIDS RESEARCH

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

Distortion-Dependent Unhooking of Interstrand Cross-Links in Mammalian Cell Extracts†

(2008) Michael B. Smeaton et al.   BIOCHEMISTRY

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

(2008) N. B. Collins et al.   BLOOD

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

Crystal structure of the Mus81-Eme1 complex

(2008) J. H. Chang et al.   GENES & DEVELOPMENT

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair

(2008) Yutong Xue et al.   HUMAN MOLECULAR GENETICS

The Fanconi Anemia Protein FANCM Can Promote Branch Migration of Holliday Junctions and Replication Forks

(2008) Kerstin Gari et al.   MOLECULAR CELL

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

(2008) Arno F. Alpi et al.   MOLECULAR CELL

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

(2008) Masamichi Ishiai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA