Filamins in Mechanosensing and Signaling

Mutations in the N-terminal Actin-Binding Domain of Filamin C Cause a Distal Myopathy

(2011) Rachael M. Duff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evidence for Multisite Ligand Binding and Stretching of Filamin by Integrin and Migfilin

(2011) Sujay Subbayya Ithychanda et al.   BIOCHEMISTRY

Filamins and the potential of complexity

(2011) Thomas P. Stossel   CELL CYCLE

Structural Portrait of Filamin Interaction Mechanisms

(2011) Kristina Djinovic-Carugo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure

(2011) Ulla Pentikäinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells

(2011) Isabelle Lamsoul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 ubiquitin ligase specificity subunit ASB2  targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain

(2011) Z. Razinia et al.   JOURNAL OF CELL SCIENCE

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

The Calcium-Sensing Receptor-Dependent Regulation of Cell–Cell Adhesion and Keratinocyte Differentiation Requires Rho and Filamin A

(2011) Chia-Ling Tu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

(2011) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Functional Evaluation of C. elegans Filamins FLN-1 and FLN-2

(2011) Christina R. DeMaso et al.   PLoS One

RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape

(2011) O. Gay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The filamins

(2011) Fumihiko Nakamura et al.   Cell Adhesion & Migration

TAN lines

(2011) G.W. Gant Luxton et al.   Nucleus

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIb -filamin interaction

(2010) S. L. Cranmer et al.   BLOOD

Real Time FRET Based Detection of Mechanical Stress in Cytoskeletal and Extracellular Matrix Proteins

(2010) Fanjie Meng et al.   Cellular and Molecular Bioengineering

FLN-1/Filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans

(2010) Ismar Kovacevic et al.   DEVELOPMENTAL BIOLOGY

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Regulation of cell adhesion to collagen via β1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon

(2010) Hugh Kim et al.   EXPERIMENTAL CELL RESEARCH

Filamin B Plays a Key Role in Vascular Endothelial Growth Factor-induced Endothelial Cell Motility through Its Interaction with Rac-1 and Vav-2

(2010) Beatriz del Valle-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Basis of the Interaction between Cystic Fibrosis Transmembrane Conductance Regulator and Immunoglobulin-like Repeats of Filamin

(2010) Laura Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis

(2010) Chaoyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A

(2010) Martin P. Playford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Filamins in cell signaling, transcription and organ development

(2010) Alex-Xianghua Zhou et al.   TRENDS IN CELL BIOLOGY

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Structure of the human filamin A actin-binding domain

(2009) Salla Ruskamo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Filamin A is required for vimentin-mediated cell adhesion and spreading

(2009) Hugh Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Filamin A Is Essential for Active Cell Stiffening but not Passive Stiffening under External Force

(2009) K.E. Kasza et al.   BIOPHYSICAL JOURNAL

Phosphorylation Facilitates the Integrin Binding of Filamin under Force

(2009) Harvey S. Chen et al.   BIOPHYSICAL JOURNAL

Absence of Filamin A Prevents Cells from Responding to Stiffness Gradients on Gels Coated with Collagen but not Fibronectin

(2009) Fitzroy J. Byfield et al.   BIOPHYSICAL JOURNAL

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

(2009) Ren Xu et al.   CANCER AND METASTASIS REVIEWS

The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation

(2009) N F Bello et al.   CELL DEATH AND DIFFERENTIATION

Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders†

(2009) Alice R. Clark et al.   HUMAN MOLECULAR GENETICS

Atomic Structures of Two Novel Immunoglobulin-like Domain Pairs in the Actin Cross-linking Protein Filamin

(2009) Outi K. Heikkinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Multiple Similar Ligand-binding Repeats in Filamin

(2009) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

(2009) Ulla Pentikäinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Disease-associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains

(2009) Gregory M. Sawyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Isoform Divergence of the Filamin Family of Proteins

(2009) B. A. Kesner et al.   MOLECULAR BIOLOGY AND EVOLUTION

Filamin A–β1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension

(2009) Scott Gehler et al.   MOLECULAR BIOLOGY OF THE CELL

The Role of FilGAP-Filamin A Interactions in Mechanoprotection

(2009) Yulia Shifrin et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

(2009) Fumihiko Nakamura et al.   PLoS One

Filamins Regulate Cell Spreading and Initiation of Cell Migration

(2009) Massimiliano Baldassarre et al.   PLoS One

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanical loading by fluid shear is sufficient to alter the cytoskeletal composition of osteoblastic cells

(2008) Wesley M. Jackson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ASB2 targets filamins A and B to proteasomal degradation

(2008) M. L. Heuze et al.   BLOOD

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD

Novel structural insights into F-actin-binding and novel functions of calponin homology domains

(2008) Björn Sjöblom et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy

(2008) Alexey Shatunov et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails

(2008) Yatish Lad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Migfilin, a Molecular Switch in Regulation of Integrin Activation

(2008) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

(2008) A. J. Engler et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the dimerization domain of human filamin A

(2008) Min-Duk Seo et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex

(2008) Matthew R. Sarkisian et al.   TRENDS IN NEUROSCIENCES

Molecular Mechanics of Filamin's Rod Domain

(2007) Kevin S. Kolahi et al.   BIOPHYSICAL JOURNAL

Filamin A regulates cell spreading and survival via β1 integrins

(2007) Hugh Kim et al.   EXPERIMENTAL CELL RESEARCH