Article
Biotechnology & Applied Microbiology
Roberta Scuoppo, Stefano Cannata, Giovanni Gentile, Caterina Gandolfo, Salvatore Pasta
Summary: This study used finite-element analysis to quantify coronary flow in a patient who underwent TAVR-in-TAVR and found that high implantation depth and device undersize of the second THV can significantly reduce coronary flow. Additionally, a positive correlation was observed between coronary flow and the valve-to-coronary distance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hong Rae Kim, Wan Kee Kim, Ho Jin Kim, Joon Bum Kim, Sung -Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
Summary: This study aims to quantify the occurrence of deterioration of native aortic valve function in patients who underwent rheumatic mitral valve surgery. The results show that progression to severe aortic valve dysfunction or requirement of subsequent aortic valve replacements is relatively uncommon, but more common among patients with mild or greater aortic valve dysfunction at baseline.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Urena, Alec Vahanian, Eric Brochet, Gregory Ducrocq, Bernard Iung, Dominique Himbert
Summary: The clinical use of TMVR using transcatheter aortic valves is limited to patients with failing bioprostheses or rings, and mitral valve disease associated with severe mitral annulus calcification. While valve-in-valve TMVR seems to be a reasonable alternative to surgery for high-risk patients, there is less evidence supporting valve-in-ring and valve-in-mitral annulus calcification interventions.
Article
Engineering, Biomedical
Jordan A. Brown, Jae H. Lee, Margaret Anne Smith, David R. Wells, Aaron Barrett, Charles Puelz, John P. Vavalle, Boyce E. Griffith
Summary: Transcatheter aortic valve replacement (TAVR) is a commonly used technique for aortic valve replacement, and computer modeling and simulation (CM&S) can assist in the design and approval process of TAVR devices. This study presents a computational fluid-structure interaction (FSI) model of TAVR using the immersed finite element-difference (IFED) method.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Alireza Heidari, Khalil Elkhodary, Cristina Pop, Mohamed Badran, Hojatollah Vali, Yousof M. A. Abdel-Raouf, Saeed Torbati, Masoud Asgharian, Russell J. Steele, Iradj Mahmoudzadeh Kani, Sara Sheibani, Hamidreza Pouraliakbar, Hakimeh Sadeghian, Renzo Cecere, Matthias G. W. Friedrich, Hossein Ahmadi Tafti
Summary: This study proposes a computational approach to simulate the effects of pulmonary hypertension caused by left heart disease on the whole heart. The findings suggest that mitral valve replacement and subsequent chamber pressure unloading significantly decrease the risk of right ventricular failure in patients with pulmonary hypertension.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Engineering, Biomedical
Gediminas Gaidulis, Kirthana Sreerangathama Suresh, Dongyang Xu, Muralidhar Padala
Summary: We developed a patient-specific computational model of the mitral valve using 3D ultrasound images to accurately simulate the pathological valve dynamics. The inclusion of patient-specific boundary conditions was found to be necessary for accurate results, and the use of idealized boundary conditions deviated from the truth dataset. Our approach of using patient-specific boundary conditions for mitral valve modeling is valid.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Cardiac & Cardiovascular Systems
Ravi A. Thakker, Ayman Elbadawi, Aiham Albaeni, Syed Mustajab Hasan, Krishna H. Suthar, Shreyas A. Modi, Rafic F. Berbarie, Wissam Khalife, Khaled F. Chatila
Summary: Cardiac amyloidosis is an infiltrative disease that severely impacts the cardiac anatomy, leading to structural changes. In rare cases, it can cause severe mitral regurgitation. Percutaneous mitral valve repair has been shown to be effective in treating cardiac amyloidosis.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yafen Liang, Abhijeet Dhoble, Adarsh Pakanati, Yelin Zhao, Felix Kork, Wei Ruan, Travis Markham, Richard Smalling, Prakash Balan, Anthony Estrera, Tom C. Nguyen, Igor Gregoric, Biswajit Kar, Holger Eltzschig
Summary: Catastrophic cardiac events during TAVR are rare but significantly increase perioperative mortality. Causes include cardiac perforation, tamponade, aortic root disruption. Early recognition and standardized team approach are crucial for managing these complications and improving patient outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Karl-Andreas Dumont, Hans Martin Dahl Aguilera, Robert Persson, Victorien Prot, John-Peder Escobar Kvitting, Stig Urheim
Summary: The onset and severity of late systolic regurgitation in Barlow's mitral valve disease are determined by annulus dynamics and mechanical stresses imposed by the left ventricle. Annulus dilatation may accentuate mitral valve regurgitation, and a novel annulus elastance index can predict the severity of regurgitation.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Engineering, Biomedical
Harshita Narang, Bruno V. Rego, Amir H. Khalighi, Ahmed Aly, Alison M. Pouch, Robert C. Gorman, Joseph H. Gorman III, Michael S. Sacks
Summary: Research shows that there are significant differences in pre-surgical mitral valve size, shape, and deformation patterns between patients with and without IMR recurrence at 6 months post-surgery. Average pre-surgical circumferential leaflet strain in the A1 region can independently predict IMR recurrence.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Francesco Nappi, Laura Mazzocchi, Cristiano Spadaccio, David Attias, Irina Timofeva, Laurent Macron, Adelaide Iervolino, Simone Morganti, Ferdinando Auricchio
Summary: Finite element analysis (FEA) was used to investigate the factors contributing to postoperative complications in transcatheter heart valves. The study found that calcifications persisting after device expansion could lead to geometric distortion and hemodynamic disturbances, potentially causing thrombosis. FEA may assist in patient selection, procedure planning, and detection and prevention of complications in TAVR.
BIOENGINEERING-BASEL
(2021)
Article
Physiology
Joel Kronborg, Frida Svelander, Samuel Eriksson-Lidbrink, Ludvig Lindstroem, Carme Homs-Pons, Didier Lucor, Johan Hoffman
Summary: This article analyzes the blood flow in the left ventricle of the heart and explores the effect of cardiac disease and clinical intervention on the blood flow. The triple decomposition method is used to study the influence of different types of flow structures on the mechanical stimuli of blood cells. The simulation of a mitral valve clip intervention is also conducted, and a sensitivity study reveals that shear force has the greatest impact on the results.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marco Guglielmo, Laura Fusini, Giuseppe Muscogiuri, Francesca Baessato, Antonella Loffreno, Annachiara Cavaliere, Giulia Rizzon, Andrea Baggiano, Mark G. Rabbat, Manuela Muratori, Gloria Tamborini, Ludovica M. L. Danza, Alberico Del Torto, Elisabetta Tonet, Giacomo Viani, Saima Mushtaq, Edoardo Conte, Giorgia Bonalumi, Paola Gripari, Marco Zanobini, Daniele Andreini, Francesco Alamanni, Mauro Pepi, Andrea I. Guaricci, Gianluca Pontone
Summary: T1 mapping and CMR feature tracking can identify subclinical left ventricle tissue changes in patients with mitral valve prolapse, showing significant alterations in myocardial strain and T1 values in different myocardial segments. Further studies are needed to correlate these subclinical tissue changes with clinical outcomes.
EUROPEAN RADIOLOGY
(2021)
Article
Engineering, Biomedical
Dong Qiu, Ali N. Azadani
Summary: This study investigates the impact of regional stent under-expansion on leaflet kinematics, leaflet structural characteristics, and the likelihood of leaflet thrombosis following transcatheter aortic valve replacement (TAVR). The results show that regional TAV frame under-expansion impairs leaflet motion and increases mechanical stress, which can lead to blood stasis and tissue degeneration. Post-procedural balloon dilatation of TAVs could be beneficial in reducing leaflet distortion and normalizing leaflet stress distribution.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Mohammad Javad Sadeghinia, Hans Martin Aguilera, Stig Urheim, Robert Matongo Persson, Vegard Skalstad Ellensen, Rune Haaverstad, Gerhard A. Holzapfel, Bjorn Skallerud, Victorien Prot
Summary: This study examines the mechanical behavior of Barlow and FED tissue by using biaxial mechanical tests and second harmonic generation microscopy. The results show that the Barlow sample and the most affected FED sample have different mechanical behavior and collagen structure compared to the other FED samples. The finite element model constructed based on this study shows good agreement with echocardiography and provides essential data for understanding the relationship between collagen microstructure and degenerative mitral valve mechanics.
ACTA BIOMATERIALIA
(2023)