期刊
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6
卷 6, 期 -, 页码 237-265出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-anchem-062012-092609
关键词
biomolecular mass spectrometry; carbohydrates; permethylation; porous graphitic carbon; sialic acids; capillary electrophoresis
资金
- NCI NIH HHS [U01 CA128535, U01CA128535] Funding Source: Medline
- NIGMS NIH HHS [R01 GM024349, R01GM024349] Funding Source: Medline
The field of glycomics has recently advanced in response to the urgent need for structural characterization and quantification of complex carbohydrates in biologically and medically important applications. The recent success of analytical glycobiology at high sensitivity reflects numerous advances in biomolecular mass spectrometry and its instrumentation, capillary and microchip separation techniques, and microchemical manipulations of carbohydrate reactivity. The multimethodological approach appears to be necessary to gain an in-depth understanding of very complex glycomes in different biological systems.
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