Article
Cardiac & Cardiovascular Systems
Tammy Hod, Katherin J. Freedberg, Shveta S. Motwani, Margaret Chen, Gyorgy Frendl, David E. Leaf, Shruti Gupta, Suraj Sarvode Mothi, William G. Richards, Raphael Bueno, Sushrut S. Waikar
Summary: After surgical resection of malignant pleural mesothelioma, acute kidney injury is common, with cisplatin hyperthermic intraoperative chemotherapy being a major risk factor. Severe acute kidney injury leads to longer hospital stays and a significantly increased risk of death.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Michelle Lee, Luigi Ventura, Ralitsa Baranowski, Joanne Hargrave, David Waller
Summary: This study evaluated the effects of an intentional change in protocol to diaphragm-sparing surgery for malignant pleural mesothelioma. The results showed improved perioperative outcomes without compromising overall survival for patients who underwent diaphragm-sparing surgery, compared to those who underwent diaphragm resection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Giuseppe Mangiameli, Edoardo Bottoni, Emanuele Voulaz, Umberto Cariboni, Alberto Testori, Alessandro Crepaldi, Veronica Maria Giudici, Emanuela Morenghi, Marco Alloisio
Summary: A retrospective analysis was conducted on MPM patients who underwent eP/D surgery in a center with high thoracic surgery experience. The study found that most patients could receive complete trimodality treatment, with acceptable postoperative morbidity and mortality rates. Factors such as major complications, operative time, and pathological node involvement were associated with worse survival outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Masaki Hashimoto, Hiroyuki Yamamoto, Shunsuke Endo, Morihito Okada, Hiroaki Miyata, Seiki Hasegawa, Masayuki Chida
Summary: This study analyzed the characteristics, surgical outcomes, and risk factors for surgical complications in patients with malignant pleural mesothelioma (MPM) using a nationwide database in Japan. The results showed that pleurectomy/decortication (P/D) was more frequently performed in high-volume centers, while extrapleural pneumonectomy (EPP) was more common in less experienced institutions. The incidence of complications was higher in EPP, but overall mortality rates were low regardless of the surgical procedure.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Seiki Hasegawa, Kohei Yokoi, Morihito Okada, Fumihiro Tanaka, Mototsugu Shimokawa, Takashi Daimon, Takashi Nakano
Summary: Neoadjuvant chemotherapy followed by pleurectomy/decortication is feasible and provides acceptable survival rates and low mortality/morbidity in the treatment of malignant pleural mesothelioma.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Federica Danuzzo, Sebastiano Maiorca, Gianluca Bonitta, Mario Nosotti
Summary: This study compared the overall survival and postoperative complications of extrapleural pneumonectomy (EPP) and pleurectomy decortication (P/D) in the treatment of malignant pleural mesothelioma (MPM) through a systematic review of the available literature. The results showed that patients undergoing P/D had better overall survival and lower 30-day mortality, but no significant difference was found in 90-day mortality. The incidence of postoperative complications, such as empyema, atrial fibrillation, bleeding, and bronchopleural fistula, was significantly higher in the EPP group, while prolonged air leakage was only characteristic of P/D.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Patrick Bou-Samra, Austin Chang, Kevin Zhang, Feredun Azari, Gregory Kennedy, Emily Guo, Wei-Ting Hwang, Sunil Singhal
Summary: This retrospective study investigated patients who underwent pleurectomy and decortication for malignant pleural mesothelioma. The results showed that performing tracheostomy, gastrostomy/jejunostomy tube placement, and therapeutic anticoagulation in addition to the standard procedure can reduce the risk of postoperative aspiration pneumonia, deep vein thrombosis, and catheter-related sepsis.
Article
Medicine, General & Internal
Stefano Bongiolatti, Francesca Mazzoni, Ottavia Salimbene, Enrico Caliman, Carlo Ammatuna, Camilla E. Comin, Lorenzo Antonuzzo, Luca Voltolini
Summary: The study focused on multimodal treatment for early-stage epithelioid MPM, including induction chemotherapy followed by P/D and HITHOC, demonstrating promising mid-term oncological results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Olivia Lauk, Miriam Patella, Thomas Neuer, Bianca Battilana, Thomas Frauenfelder, Thi Dan Linh Nguyen-Kim, Walter Weder, Claudio Caviezel, Sven Hillinger, Ilhan Inci, Isabelle Opitz
Summary: Tumor thickness and volume measured by CT can predict the survival prognosis of malignant pleural mesothelioma patients. Significant correlation was found between pathological tumor volume and actual tumor volume. CT tumor volume may serve as a valuable addition to future staging systems.
Article
Surgery
Masatoshi Kanayama, Masataka Mori, Hiroki Matsumiya, Akihiro Taira, Shinji Shinohara, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka
Summary: This study compared the outcomes and survival of extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) for malignant pleural mesothelioma (MPM). The results showed that compared to EPP, P/D was associated with higher intraoperative bleeding volume and longer duration of postoperative thoracic drainage. However, for epithelioid-type MPM, patients who underwent P/D had better survival rates. Therefore, P/D may be superior to EPP for improving the prognosis of resectable epithelioid-type MPM patients.
Article
Oncology
Frederic Larose, Nicholas Quigley, Yves Lacasse, Simon Martel, Loic Lang-Lazdunski
Summary: Comparing the overall survival rates of patients receiving multimodality therapy with aggressive cancer-directed surgery, systemic chemotherapy, and prophylactic radiotherapy to those receiving solely medical treatment, it was found that the former group showed a significant survival benefit in selected patients.
Article
Oncology
Francesco Falanga, Pietro Rinaldi, Cristiano Primiceri, Chandra Bortolotto, Olga Oneta, Francesco Agustoni, Patrizia Morbini, Laura Saracino, Dimitrios Eleftheriou, Federico Sottotetti, Giulia Maria Stella
Summary: Surgery is an option for the treatment of malignant pleural mesothelioma, but its efficacy is still debated. This study analyzed the perioperative data of 19 MPM patients who underwent EPD surgery with curative intent, and found that upfront EPD followed by ACT had better short-term outcomes.
Article
Medicine, General & Internal
Giuseppe Mangiameli, Edoardo Bottoni, Umberto Cariboni, Giorgio Maria Ferraroli, Emanuela Morenghi, Veronica Maria Giudici, Emanuele Voulaz, Marco Alloisio, Alberto Testori
Summary: This study compares the perioperative outcomes and long-term survival of malignant pleural mesothelioma (MPM) patients who underwent extended pleurectomy and decortication (eP/D) and extrapleural pneumonectomy (EPP). The results demonstrate that eP/D can be a well-tolerated surgical procedure with comparable oncological outcomes to EPP, especially in carefully selected patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Riccardo Taje, Roberto Fiorito, Alexandro Patirelis, Valentina Marziali, Vincenzo Ambrogi
Summary: This study compared the effects of pleurectomy/decortication and extrapleural pneumonectomy on symptoms and quality of life in patients with high symptom burden mesothelioma. The results showed that while extrapleural pneumonectomy had lower pain at 12 months, it had a higher decrement of forced vital capacity at 24 months compared to pleurectomy/decortication. Both procedures improved many symptoms and quality of life determinants at 3 months, but the improvement lasted longer in the extrapleural pneumonectomy group. There were no differences in chemotherapy compliance and survival between the two groups. Age at presentation and non-epitheliod histology were the only significant prognosticators. These findings suggest that surgery can improve symptoms and quality of life in patients with high symptom burden mesothelioma, with extrapleural pneumonectomy having the most durable effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Dong-Seok Lee, Andrea Carollo, Naomi Alpert, Emanuela Taioli, Raja Flores
Summary: Minimally invasive surgery is a feasible alternative to radical surgery in malignant pleural mesothelioma patients, providing improved short-term outcomes and potentially enhancing quality of life.
Article
Critical Care Medicine
Christopher R. Gilbert, Momen M. Wahidi, Richard W. Light, M. Patricia Rivera, Daniel H. Sterman, Rajesh Thomas, Samira Shojaee, Shmuel Shoham, Ioannis Psallidas, David E. Ost, Daniela Molena, Nick Maskell, Fabien Maldonado, Moishe Liberman, Y. C. Gary Lee, Hans Lee, Felix J. F. Herth, Horiana Grosu, Jed A. Gorden, Edward T. H. Fysh, John P. Corcoran, A. Christine Argento, Jason A. Akulian, Najib M. Rahman, Lonny B. Yarmus
Article
Gastroenterology & Hepatology
Daniel J. Becker, Arjun D. Iyengar, Salman R. Punekar, Dalia Kaakour, Megan Griffin, Joseph Nicholson, Heather T. Gold
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Letter
Oncology
Salman R. Punekar, Daniel J. Becker
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Oncology
Sharyn Katz, Leonid Roshkovan, Ian Berger, Joseph S. Friedberg, Evan W. Alley, Charles B. Simone, Andrew R. Haas, Keith A. Cengel, Daniel H. Sterman, Steven M. Albelda
Summary: Serum levels of SMRP and fibulin-3 show correlation with tumor volume in malignant pleural mesothelioma, but are not useful in predicting tumor response in immunogene therapy trial.
Article
Medicine, General & Internal
Roxana Sulica, Frank Cefali, Caroline Motschwiller, Rebecca Fenton, Anabela Barroso, Daniel Sterman
Summary: Limited data exists on COVID-19 outcomes in patients with pulmonary arterial hypertension (PAH). A study from a Pulmonary Hypertension Center in New York City during the pandemic found that majority of PAH patients with SARS-CoV-2 infection required intensive care and had a high mortality rate. The study emphasizes the seriousness of COVID-19 in PAH patients and suggests interventions such as social distancing, PAH management optimization, and specialized care for better outcomes.
Article
Oncology
I. Berger, Scott Simpson, JS. Friedberg, Melissa J. Culligan, E. Paul Wileyto, Evan W. Alley, D. Sterman, Akash M. Patel, U. Khalid, C. B. Simone, Keith A. Cengel, Sharyn I. Katz, L. Roshkovan
Summary: This study aimed to determine if MPM PILN metastasis can be reliably detected on CT. The results showed that CT does not reliably identify metastatic PILN in MPM patients undergoing eP/D.
Article
Environmental Sciences
Nedim Durmus, Sultan Pehlivan, Yian Zhang, Yongzhao Shao, Alan A. Arslan, Rachel Corona, Ian Henderson, Daniel H. Sterman, Joan Reibman
Summary: The study characterized lung cancer patients at the WTC Environmental Health Center and found that a majority of lung cancer patients were female, with a significant portion being never-smokers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Payal Shah, Salman R. Punekar, Anna C. Pavlick
Summary: Research showed that a high percentage of patients experience high-grade irAE recurrence after rechallenge with ICI therapy, but some patients still achieve clinical response. The time from initial ICI treatment to death or disease progression and the duration to rechallenge have an impact on disease progression. Longer durations to rechallenge may lower the risk of disease progression.
Article
Pharmacology & Pharmacy
Shari B. Brosnahan, Xian Jie Cindy Chen, Juri Chung, Diana Altshuler, Shahidul Islam, Sarun Thomas, Megan D. Winner, Allison A. Greco, Jasmin Divers, Peter Spiegler, Daniel H. Sterman, Sam Parnia
Summary: Severe hypoxic respiratory failure from COVID-19 pneumonia poses high mortality risk, and the combination of tocilizumab and corticosteroids has shown improved 28-day survival without increasing risk of infection in comparison to corticosteroids alone. The study highlights the potential benefits of modifying steroid dosing strategies and types for optimizing COVID-19 treatment effects.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Oncology
Salman Rafi Punekar, Rochelle Castillo, Sabina Sandigursky, Daniel Chang Cho
Summary: ICIs are medications targeting immune pathways and have shown success in treating many cancers, but can also lead to immune-related adverse events and worsening of underlying autoimmune conditions. This report discusses a case in which a patient with metastatic renal cell carcinoma experienced exacerbation of paraneoplastic dermatomyositis after ICI treatment and successfully continued with the help of intravenous immunoglobulin.
JOURNAL OF IMMUNOTHERAPY
(2021)
Article
Microbiology
Imran Sulaiman, Matthew Chung, Luis Angel, Jun-Chieh J. Tsay, Benjamin G. Wu, Stephen T. Yeung, Kelsey Krolikowski, Yonghua Li, Ralf Duerr, Rosemary Schluger, Sara A. Thannickal, Akiko Koide, Samaan Rafeq, Clea Barnett, Radu Postelnicu, Chang Wang, Stephanie Banakis, Lizzette Perez-Perez, Guomiao Shen, George Jour, Peter Meyn, Joseph Carpenito, Xiuxiu Liu, Kun Ji, Destiny Collazo, Anthony Labarbiera, Nancy Amoroso, Shari Brosnahan, Vikramjit Mukherjee, David Kaufman, Jan Bakker, Anthony Lubinsky, Deepak Pradhan, Daniel H. Sterman, Michael Weiden, Adriana Hegu, Laura Evans, Timothy M. Uyeki, Jose C. Clemente, Emmie de Wit, Ann Marie Schmidt, Bo Shopsin, Ludovic Desvignes, Chan Wang, Huilin Li, Bin Zhang, Christian Forst, Shohei Koide, Kenneth A. Stapleford, Kamal M. Khanna, Elodie Ghedin, Leopoldo N. Segal
Summary: Analysis of lower respiratory tract microbiome of mechanically ventilated COVID-19 patients rules out a role for secondary respiratory infections as drivers of increased mortality. Mortality is more likely associated with viral replication levels, host immune response, and enrichment of specific microbes.
NATURE MICROBIOLOGY
(2021)
Article
Oncology
Salman R. Punekar, Megan M. Griffin, Lena Masri, Stefanie D. Roman, Danil Makarov, Scott E. Sherman, Daniel J. Becker
Summary: This study found a low rate of KRAS testing in CRC patients, with those living in low-income areas less likely to be tested, even after controlling for Medicaid insurance. Despite the decreased risk of death in patients who received KRAS testing, socioeconomic disparities persist, indicating that further efforts are needed to address these disparities.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Editorial Material
Oncology
Fei Shu, Salman R. Punekar, Vamsidhar Velcheti, Miguel F. Sanmamed, Jun Wang
Summary: 4-1BB has long been considered a promising target for cancer immunotherapy, but early targeted agents showed significant liver toxicity. A new approach is being developed to circumvent hepatotoxicity by directing 4-1BB agonism to the tumor microenvironment using a bispecific molecule targeting the tumor-associated immune checkpoint molecule PD-L1.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Salman R. Punekar, Jeffrey S. Weber
Summary: Tilsotolimod, a TLR9 agonist, administered intratumorally, has the ability to change the tumor microenvironment, converting noninflamed tumors into inflamed ones and potentially increasing their responsiveness to immune checkpoint blockade.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jun-Chieh J. Tsay, Benjamin G. Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T. Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L. Bessich, Robert L. Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L. Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N. Rom, Daniel H. Sterman, Harvey Pass, Jose C. Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos, Leopoldo N. Segal
Summary: In lung cancer patients, dysbiosis of the lower airway microbiota is more prevalent in advanced stages and associated with poor prognosis, upregulation of IL17, PI3K pathways, etc. in the airway transcriptome. The dysbiosis with V. parvula in the lower airway of the KP lung cancer model leads to decreased survival and tumor progression.