Article
Oncology
Po-Kuei Hsu, Yi-Chen Yeh, Ling- Chien, Chien-Sheng Huang, Han-Shui Hsu
Summary: Pathologic complete lymph node regression may be an indicator of sensitivity to neoadjuvant treatment and serves as a good prognostic factor in patients with esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Emilie D. Duchesneau, Selena J. An, Paula D. Strassle, Katherine E. Reeder-Hayes, Kristalyn K. Gallagher, David W. Ollila, Stephanie M. Downs-Canner, Philip M. Spanheimer
Summary: The optimal treatment strategy for small node-negative HER2+ breast cancer remains controversial. We investigated patient characteristics associated with the receipt of neoadjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wilson Luiz Jr Jr da Costa, Xiangjun Gu, Farhood Farjah, Shawn S. Groth, Bryan M. Burt, Robert T. Ripley, Phillip W. Carrott, Nader N. Massarweh
Summary: Inaccurate clinical staging information for esophageal adenocarcinoma patients may lead to deviations from treatment guidelines, which should be a new focus for quality improvement efforts.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Selena J. An, Emilie D. Duchesneau, Paula D. Strassle, Katherine Reeder-Hayes, Kristalyn K. Gallagher, David W. Ollila, Stephanie M. Downs-Canner, Philip M. Spanheimer
Summary: Women with small HER2+ breast cancers may have excellent prognosis with adjuvant single-agent chemotherapy and HER2-targeted therapy. The role of de-escalated therapy in the neoadjuvant setting, however, remains uncertain.
Article
Oncology
Felix Ho, Robert J. Torphy, Chloe Friedman, Stephen Leong, Sunnie Kim, Sachin Wani, Tracey Schefter, Christopher D. Scott, John D. Mitchell, Michael J. Weyant, Robert A. Meguid, Ana L. Gleisner, Karyn A. Goodman, Martin D. McCarter
Summary: In patients with esophageal and gastroesophageal junction adenocarcinoma, induction chemotherapy before neoadjuvant chemotherapy with concurrent radiotherapy was associated with significantly improved overall survival and higher pathological complete response rate. Furthermore, in patients diagnosed from 2013 to 2015, induction chemotherapy with neoadjuvant chemotherapy and concurrent radiotherapy was also linked to a higher odds of achieving pathological complete response.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Catarina Macedo-Silva, Vera Constancio, Vera Miranda-Goncalves, Pedro Leite-Silva, Sofia Salta, Joao Lobo, Rita Guimaraes, Carina Carvalho-Maia, Davide Gigliano, Monica Farinha, Olga Sousa, Rui Henrique, Carmen Jeronimo
Summary: In this study, we found that the methylation levels of miR129-2, miR124-3, and ZNF569 can accurately differentiate esophageal cancer from normal esophagus, especially in adenocarcinoma patients, both pre- and post-chemoradiation therapy. Additionally, a methylation panel of miR129-2/ZNF569 showed a sensitivity of 53% and specificity of 87% in detecting esophageal cancer in liquid biopsies. These findings support the use of miRNA methylation biomarkers as a novel approach for esophageal cancer detection and chemoradiation therapy response monitoring.
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Gastroenterology & Hepatology
Puja G. Khaitan, Tyler Holliday, Austin Carroll, Wayne L. Hofstetter, Erin M. Bayley, Nicolas Zhou, Sameer Desale, Thomas J. Watson
Summary: This study assessed the correlation between clinical complete response (ycCR) and pathologic complete response (ypCR) and found that current restaging tools cannot reliably predict ypCR after neoadjuvant chemoradiotherapy (nCRT). Although multimodal restaging appears to be a more accurate predictor of ypCR than any individual testing modality, ycCR cannot be relied upon to determine the need for esophagectomy.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Immunology
Yanru Mu, Hui Wang, Tao He, Li Xu
Summary: This study found that patients with locally advanced squamous cell esophageal carcinoma may benefit from preoperative neoadjuvant chemoradiotherapy with a high radiation dosage, leading to higher survival rates, lower local recurrence, and distant metastasis rates.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
David T. Pointer, Jordan A. McDonald, Samer A. Naffouje, Rutika Mehta, Jason B. Fleming, Jacques P. Fontaine, Gregory Y. Lauwers, Jessica M. Frakes, Sarah E. Hoffe, Jose M. Pimiento
Summary: This study aimed to evaluate the association between histologic grade and prognosis in esophageal cancer patients who received neoadjuvant chemoradiation followed by resection. The study found that patients with post-neoadjuvant therapy histologic grade 1-2 had improved survival. Integrating histologic grade into postneoadjuvant staging may be necessary.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jae Kwang Yun, Hyeong Ryul Kim, Seung Il Park, Yong-Hee Kim
Summary: This study aimed to investigate long-term survival outcomes and develop a risk model for occult lymph node metastasis (LNM) in patients with clinical T1 through T2 N0 esophageal squamous cell carcinoma. Results showed that occult LNM was associated with worse prognosis and had similar outcomes to clinical T1 through T2 N+ cancer. According to the risk model, tumor maximum standardized uptake, histological differentiation grade, tumor length, and advanced clinical T stage were independent risk factors for occult LNM in clinical T1 through T2 N0 cancer. The risk scoring system based on this model exhibited high accuracy and good discriminant ability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Muhammad M. Qureshi, Yue Lin, Alexander R. Moeller, Sherry X. Yan, Michael A. Dyer, Kei Suzuki, Peter Everett, Virginia Litle, Minh-Tam Truong, Kimberley S. Mak
Summary: The study aimed to determine if change in stage after neoadjuvant chemoradiation (CRT) was associated with improved survival in esophageal cancer using a national database. The results showed that pathologic complete response (pCR) was strongly associated with improved overall survival (OS), while downstaged, same-staged, and upstaged tumors were associated with a stepwise decline in survival.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Filippo Crimi, Giulio Cabrelle, Cristina Campi, Alessio Schillaci, Quoc Riccardo Bao, Alessia Pepe, Gaya Spolverato, Salvatore Pucciarelli, Federica Vernuccio, Emilio Quaia
Summary: This study compares the diagnostic accuracy of different MRI dimensional criteria for nodal staging in patients with LARC after nCRT, and finds that measurement of the long axis and volume of the largest lymph node is not inferior to the ESGAR criteria, providing a faster and reliable alternative.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Oncology
Xiaokun Li, Siyuan Luan, Yushang Yang, Jianfeng Zhou, Qixin Shang, Pinhao Fang, Xin Xiao, Hanlu Zhang, Yong Yuan
Summary: This study aimed to explore the effectiveness of adjuvant therapy after trimodal therapy (neoadjuvant chemoradiotherapy and esophagectomy) in patients with thoracic esophageal squamous cell carcinoma (ESCC). The results showed that adjuvant therapy could reduce the overall survival (OS) and disease-free survival (DFS) in ESCC patients. It is not recommended for patients without nodal metastases after neoadjuvant therapy.
Article
Oncology
Alicia Hulbert, Ignacio Jusue-Torres, Alejandro Stark, Chen Chen, Kristen Rodgers, Beverly Lee, Candace Griffin, Andrew Yang, Peng Huang, John Wrangle, Steven A. Belinsky, Tza-Huei Wang, Stephen C. Yang, Stephen B. Baylin, Malcolm V. Brock, James G. Herman
CLINICAL CANCER RESEARCH
(2017)
Article
Clinical Neurology
Ignacio Jusue-Torres, Lee H. Jeon, Eric W. Sankey, Jennifer Lu, Tito Vivas-Buitrago, Joshua A. Crawford, Mikhail V. Pletnikov, Jiadi Xu, Ari Blitz, Daniel A. Herzka, Barbara Crain, Alicia Hulbert, Hugo Guerrero-Cazares, Oscar Gonzalez-Perez, James P. McAllister, Alfredo Quinones-Hinojosa, Daniele Rigamonti
Review
Oncology
Muyun Peng, Chen Chen, Alicia Hulbert, Malcolm V. Brock, Fenglei Yu
Article
Cardiac & Cardiovascular Systems
Dan C. Li, Alicia Hulbert, Benjamin Waldbaum, Cecily Ober, Craig M. Hooker, Peng Huang, Daniela Molena, Stephen C. Yang, Tomoaki Ito, Carisa Perry-Parrish, Malcolm V. Brock
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2018)
Review
Respiratory System
Lane Lerner, Robert Winn, Alicia Hulbert
JOURNAL OF THORACIC DISEASE
(2018)
Article
Clinical Neurology
Ignacio Jusue-Torres, Alicia Hulbert, Arpita A. Germanwala, Chirag R. Patel, Anand Germanwala
WORLD NEUROSURGERY
(2018)
Article
Oncology
Kiichi Sugimoto, Tomoaki Ito, Alicia Hulbert, Chen Chen, Hajime Orita, Masahiro Maeda, Hiroshi Moro, Takeo Fukagawa, Toshikazu Ushijima, Hitoshi Katai, Ryo Wada, Koichi Sato, Kazuhiro Sakamoto, Wayne Yu, Michael Considine, Leslie Cope, Malcolm V. Brock
Letter
Clinical Neurology
Ignacio Jusue-Torres, Alicia Hulbert, Arpita A. Germanwala, Chirag R. Patel, Anand V. Germanwala
WORLD NEUROSURGERY
(2019)
Article
Oncology
Karriem Sadot Watson, Alicia Hulbert, Vida Henderson, Ifeanyi Beverly Chukwudozie, Lisa Aponte-Soto, Lane Lerner, Erica Martinez, Sage Kim, Robert A. Winn
FRONTIERS IN ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Zhihao Lu, Jianling Zou, Shuang Li, Michael J. Topper, Yong Tao, Hao Zhang, Xi Jiao, Wenbing Xie, Xiangqian Kong, Michelle Vaz, Huili Li, Yi Cai, Limin Xia, Peng Huang, Kristen Rodgers, Beverly Lee, Joanne B. Riemer, Chi-Ping Day, Ray-Whay Chiu Yen, Ying Cui, Yujiao Wang, Yanni Wang, Weiqiang Zhang, Hariharan Easwaran, Alicia Hulbert, KiBem Kim, Rosalyn A. Juergens, Stephen C. Yang, Richard J. Battafarano, Errol L. Bush, Stephen R. Broderick, Stephen M. Cattaneo, Julie R. Brahmer, Charles M. Rudin, John Wrangle, Yuping Mei, Young J. Kim, Bin Zhang, Ken Kang-Hsin Wang, Patrick M. Forde, Joseph B. Margolick, Barry D. Nelkin, Cynthia A. Zahnow, Drew M. Pardoll, Franck Housseau, Stephen B. Baylin, Lin Shen, Malcolm V. Brock
Article
Oncology
Hiroshi Maekawa, Tomoaki Ito, Hajime Orita, Tomoyuki Kushida, Mutsumi Sakurada, Koichi Sato, Alicia Hulbert, Malcolm V. Brock
Article
Oncology
Chen Chen, Xiaojie Huang, Wei Yin, Muyun Peng, Fang Wu, Xia Wu, Jingqun Tang, Mingjiu Chen, Xiang Wang, Alicia Hulbert, Malcolm V. Brock, Wenliang Liu, James G. Herman, Fenglei Yu
CLINICAL EPIGENETICS
(2020)
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia E. Kottorou, Kristen Rodgers, John Timothy Sherwood, Georgia-Angeliki Koliou, Beverly Lee, Andrew Yang, Julie Renee Brahmer, Stephen B. Baylin, Stephen C. Yang, Hajime Orita, Alicia Hulbert, Malcolm Brock
Summary: The study examines the clinical significance of CD9-positive plasma exosomes in lung cancer patients, healthy individuals, and HIV-positive patients. The results suggest that CD9-positive plasma exosomes are associated with different populations and survival outcomes.
Article
Medicine, General & Internal
Ignacio Jusue-Torres, Jennifer Lu, Jamie Robison, Jamie B. Hoffberger, Alicia Hulbert, Abanti Sanyal, Jan Wemmer, Benjamin D. Elder, Daniele Rigamonti
CUREUS JOURNAL OF MEDICAL SCIENCE
(2016)
Meeting Abstract
Oncology
Fotinos-Ioannis D. Dimtrakopoulos, Anastasia Kottorou, Andrew Yang, Kristen Rodgers, Stephen Baylin, Alicia Hulbert, Malcolm Brock
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)