Article
Medicine, General & Internal
Ziad Arow, Tzipi Hornik-Lurie, Mustafa Gabarin, Alexander Omelchenko, Rami Barashi, Yoav Arnson, Abid Assali, David Pereg
Summary: Left atrial appendage occlusion (LAAO) is an effective and relatively safe treatment for preventing thromboembolic events in atrial fibrillation patients with a contraindication for anticoagulation. However, the long-term prognosis after the procedure remains poor with a substantial risk of thrombotic and bleeding events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Prabhakar Rajiah, Mohamad Alkhouli, Jeremy Thaden, Thomas Foley, Eric Williamson, Praveen Ranganath
Summary: Transcatheter left atrial appendage closure is an alternative to long-term anticoagulation therapy for selected patients with nonvalvular atrial fibrillation at increased risk for stroke. CT has emerged as a less-invasive alternative to TEE for pre- and postprocedural imaging, providing accurate measurements and evaluation of adjacent structures. CT also allows for assessment of postprocedural complications such as incomplete closure and device-related issues.
Review
Cardiac & Cardiovascular Systems
Shijie Zhang, Yuqi Cui, Jinzhang Li, Hongbo Tian, Yan Yun, Xiaoming Zhou, Hui Fang, Haizhou Zhang, Chengwei Zou, Xiaochun Ma
Summary: This meta-analysis compares the safety and efficacy outcomes of catheter left atrial appendage occlusion combined with ablation (COA) and thoracoscopic surgical left atrial appendage clipping combined with ablation (TCA) in patients with atrial fibrillation (AFib). The results show that after a follow-up of at least 12 months, COA and TCA do not differ in stroke prevention and all-cause mortality. The postprocedural complications and mortality are also comparable between the two groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Richard P. Whitlock, Emilie P. Belley-Cote, Domenico Paparella, Jeff S. Healey, Katheryn Brady, Mukul Sharma, Wilko Reents, Petr Budera, Andony J. Baddour, Petr Fila, P. J. Devereaux, Alexander Bogachev-Prokophiev, Andreas Boening, Kevin H. T. Teoh, Georgios I. Tagarakis, Mark S. Slaughter, Alistair G. Royse, Shay McGuinness, Marco Alings, Prakash P. Punjabi, C. David Mazer, Richard J. Folkeringa, Andrea Colli, Alvaro Avezum, Juliet Nakamya, Kumar Balasubramanian, Jessica Vincent, Pierre Voisine, Andre Lamy, Salim Yusuf, Stuart J. Connolly
Summary: Surgical occlusion of the left atrial appendage has been shown to reduce the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation undergoing cardiac surgery, with no significant difference in perioperative complications between the occlusion and non-occlusion groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yoichi Takaya, Rie Nakayama, Fumi Yokohama, Norihisa Toh, Koji Nakagawa, Masakazu Miyamoto, Hiroshi Ito
Summary: The size of the left atrial appendage (LAA) increases as atrial fibrillation (AF) progresses, with patients with long-standing persistent AF having larger LAA ostial diameter and depth. LAA ostial diameter is correlated with left atrial volume index and the duration of continuous AF.
Editorial Material
Medicine, General & Internal
Richard L. Page
Summary: Oral anticoagulation therapy is strongly recommended for high-risk patients with nonvalvular atrial fibrillation to reduce the risk of stroke, as guided by specific risk scores.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tasveer Khawaja, Monil Majmundar, Zachary Zuzek, Shilpkumar Arora, Guilherme F. Attizzani, Steven J. Filby, Yasir Abu-Omar, Mehdi H. Shishehbor, Judith A. Mackall, Anene Ukaigwe
Summary: Left atrial appendage closure (LAAC) in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) can reduce the risk of ischaemic and haemorrhagic stroke, TIA, and all-cause mortality.
Article
Cardiac & Cardiovascular Systems
David R. Holmes Jr, Kasper Korsholm, Josep Rodes-Cabau, Jacqueline Saw, Sergio Berti, Mohamad A. Alkhouli
Summary: Prevention of stroke is crucial in health systems, and various methods have been developed for different patient groups. These methods include oral anticoagulation, revascularization procedures, device closure, and left atrial appendage occlusion.
Article
Cardiac & Cardiovascular Systems
Gordon X. Wong, Saibal Kar, Thomas W. Smith, Taylor Spangler, Steven F. Bolling, Jason H. Rogers
Summary: This study evaluates the safety and efficacy of the Laminar LAA exclusion device in healthy animals and human subjects with nonvalvular atrial fibrillation. The results show successful implantation of the device in both animal and human trials, with no safety events found during 12 months of follow-up, effectively closing the left atrial appendage and reducing the risk of cardiac thrombus.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamad Alkhouli, Ole De Backer, Christopher R. Ellis, Jens Erik Nielsen-Kudsk, Horst Sievert, Andrea Natale, Dhanunjaya Lakkireddy, David R. Holmes
Summary: This paper reviewed the available research on the frequency, mechanisms, clinical significance, and management of peridevice leak after percutaneous left atrial appendage occlusion.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Thibaut Pommier, Thibault Leclercq, Charles Guenancia, Carole Richard, Guillaume Porot, Gabriel Laurent, Luc Lorgis
Summary: The LAAO technique does not seem to impact BNP levels despite inducing left atrial remodeling as measured by a CT scan. The proportion of patients with reverse atrial remodeling during follow-up was relatively low.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Richard P. Whitlock, Emilie P. Belley-Cote
Summary: This review discusses the impact of left atrial appendage occlusion on stroke, particularly in patients with atrial fibrillation. The LAAOS III research program provides definitive evidence for the benefit of surgical left atrial appendage occlusion in reducing the risk of ischemic stroke and systemic embolism in patients undergoing cardiac surgery. However, the role of surgical left atrial appendage occlusion in patients without atrial fibrillation and as a substitute to anticoagulation remains unclear.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Binhao Wang, Bin He, Guohua Fu, Mingjun Feng, Xianfeng Du, Jing Liu, Yibo Yu, Huimin Chu
Summary: This study reports on the safety and efficacy of LA catheter ablation in patients with nitinol cage or plug LAAO devices. The results showed that a proportion of patients experienced recurrence of LA tachyarrhythmias during follow-up, but no strokes or major bleeding events occurred.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Fareed Moses S. Collado, Claudia M. Lama von Buchwald, Christina K. Anderson, Nidhi Madan, Hussam S. Suradi, Henry D. Huang, Hani Jneid, Clifford J. Kavinsky
Summary: The majority of embolic strokes in patients with nonvalvular atrial fibrillation are caused by thrombi in the left atrial appendage. It is projected that strokes related to atrial fibrillation will increase unless effective mitigation strategies are implemented. Systemic anticoagulation is effective in reducing stroke risk, but bleeding complications and nonadherence can be barriers. Surgical and percutaneous left atrial appendage occlusion devices are nonpharmacologic strategies to mitigate drug therapy challenges.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Johannes Rotta detto Loria, Steffen Desch, Janine Poess, Katharina Kirsch, Holger Thiele, Marcus Sandri
Summary: This systematic review provides a comprehensive evaluation of the clinical application of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) over the past two decades, including anatomical features, patient selection, procedural planning and execution, complications, medical treatment following the procedure, and contemporary outcome data.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Harveen K. Lamba, Mary Kim, Adriana Santiago, Samuel Hudson, Andrew B. Civitello, Ajith P. Nair, Gabriel Loor, Alexis E. Shafii, Kenneth K. Liao, Subhasis Chatterjee
Summary: The study assessed outcomes of critically ill patients undergoing CF-LVAD implantation, showing no significant differences in 30-day mortality and 1-year survival rates between patients who received ECMO bridging and those who did not in INTERMACS profile 1 patients. Patients who survived after ECMO initiation had lower lactate levels following CF-LVAD implantation.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Subhasis Chatterjee, Daniel T. Engelman
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Subhasis Chatterjee, Ann Shi, Luke Yoon, Susan Y. Green, Qianzi Zhang, Hiruni S. Amarasekara, Vicente Orozco-Sevilla, Ourania Preventza, Scott A. LeMaire, Joseph S. Coselli
Summary: This study investigated whether muscle loss would affect survival after thoracoabdominal aortic aneurysm repair. Data from patients aged 60 years or older who underwent the surgery from 2006 to 2016 were retrospectively analyzed. The results showed that sarcopenia did not influence early mortality or midterm survival, but was associated with an increased risk for delayed and persistent paraplegia.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
J. W. Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W. Haft, Rakesh C. Arora
Summary: The high transmissibility of SARS-CoV-2 and severity of COVID-19 have created a global health emergency. The virus enters host cells through the spike membrane protein, with angiotensin-converting enzyme 2 as the receptor. The pandemic has tested the global health infrastructure and led to the exploration of new strategies. ECMO has been used as a rescue option, but there is no consensus on a specific scoring system for its severity assessment.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Sanam Verma, Sarah Rathwell, Stephen Fremes, Yinggan Zheng, Rajendra Mehta, Renato D. Lopes, John H. Alexander, Shaun G. Goodman, Sean van Diepen
Summary: This study described the variables and outcomes associated with peri-operative mechanical circulatory support (MCS) utilization among patients undergoing cardiac surgery. The study found that the use of MCS was associated with a higher risk of post-operative mortality and was influenced by factors such as combined coronary artery bypass grafting and valve surgery, history of lung disease, and history of heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Michael W. A. Chu, Marc Ruel, Allen Graeve, Marc W. Gerdisch, Ralph J. Damiano Jr, Robert L. Smith II, William Brent Keeling, Michael A. Wait, Robert C. Hagberg, Reed D. Quinn, Gulshan K. Sethi, Rosario Floridia, Christopher J. Barreiro, Andrew L. Pruitt, Kevin D. Accola, Francois Dagenais, Alan H. Markowitz, Jian Ye, Michael E. Sekela, Ryan Y. Tsuda, David A. Duncan, Daniel G. Swistel, Lacy E. Harville III, Joseph J. DeRose, Eric J. Lehr, John H. Alexander, John D. Puskas
Summary: This study aimed to assess the safety and efficacy of low-dose warfarin in patients with mechanical mitral valve replacement. The results showed that low-dose warfarin did not achieve noninferiority for the composite primary end point compared to standard-dose warfarin. The difference in the annual incidence rate between the two groups was very small during the 4.1 years of follow-up. Therefore, the current target international normalized ratio range (2.5-3.5) may still be the recommended treatment range for patients with mechanical mitral valve replacement.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Ziad Hijazi, Alexander P. Benz, Johan Lindback, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Christopher B. Granger, Peter Kastner, Renato D. Lopes, Andre Ziegler, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
Summary: In this study, BMP10 may be a novel specific biomarker of ischaemic stroke in patients with atrial fibrillation, irrespective of oral anticoagulation.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Mario Gaudino, John Alexander, Umberto Benedetto, Andreas Boening, Arnaldo Dimagli, Stephen Fremes, Joanna Chikwe, Leonard Girardi, David Hare, Paul Kurlansky, Andre Lamy, Katia Audisio, Antonino Di Franco, P. J. Devereaux, Anno Diegeler, Marcus Flather, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Guillaume Marquis-Gravel, Laurie-Anne Boivin-Proulx, Zhen Huang, Steven L. Zelenkofske, A. Michael Lincoff, Roxana Mehran, P. Gabriel Steg, Christoph Bode, John H. Alexander, Thomas J. Povsic
Summary: This study compared the effectiveness of vascular closure devices (VCDs) with manual compression in reducing bleeding after transfemoral percutaneous coronary intervention. The results showed that there was no significant difference in bleeding rate between the two groups, but the VCD group had shorter recovery time. Further investigation is needed for high-bleeding risk populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Gilles Montalescot, John H. Alexander, Angel Cequier-Fillat, Scott D. Solomon, Alban Redheuil, Martin Hudec, Johanne Silvain, Nadjia Kachenoura, Adam Janas, Marek Orban, Isabelle Josse, Fabrice Balavoine, Bruno Besse
Summary: This study compared the effects of firibastat and ramipril on post-myocardial infarction (MI) left ventricular ejection fraction (LVEF) and found that both drugs had similar efficacy in preventing left ventricular dysfunction after acute anterior MI, with comparable safety profiles.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2023)
Review
Cardiac & Cardiovascular Systems
Josephine Harrington, Jonathan P. Piccini, John H. Alexander, Christopher B. Granger, Manesh R. Patel
Summary: FXIa inhibitors have the potential to improve precision in anticoagulation by primarily targeting thrombus formation while sparing clotting and hemostasis. Observational data and small phase 2 trials have shown promising results in terms of bleeding, safety, and prevention of venous thromboembolism. Larger clinical trials are needed to determine the role of FXIa inhibitors in different patient populations.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Arsalan Amin, Subhasis Chatterjee
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Medicine, General & Internal
John H. H. Alexander
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ziad Hijazi, Johan Lindbaeck, Jonas Oldgren, Alexander P. Benz, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Christopher B. Granger, Renato D. Lopes, Agneta Siegbahn, Lars Wallentin
Summary: This study evaluated the net clinical outcome of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and identified clinically relevant thresholds for OAC treatment decisions. The findings showed that OAC treatment provides greater net clinical benefit than no-OAC treatment in patients with higher stroke risk, while a balanced decision is needed for patients with lower stroke risk.
AMERICAN HEART JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marat Fudim, Renato D. Lopes, Daniel M. Wojdyla, Roxana Mehran, Mohammad S. Khan, Christopher B. Granger, Shaun G. Goodman, Ron Aronson, Stephan Windecker, John H. Alexander
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)
