Article
Oncology
Yacoub A. Yousef, Ibrahim Qaddoumi, Ibrahim Al-Nawaiseh, Mona Mohammad, Dalia AlRimawi, Mario Damiano Toro, Sandrine Zweifel, Robert Rejdak, Rashed Nazzal, Mustafa Mehyar, Imad Jaradat, Iyad Sultan, Maysa Al-Hussaini
Summary: This study assessed the comparative prognostic values of the 7th and 8th editions of the AJCC clinical staging manual for retinoblastoma (RB) and suggested modifications for future editions. The proposed modifications provided better prognostic value for eye globe salvage and resolved discrepancies in previously published classification systems for RB.
Article
Oncology
Alexander B. Olawaiye, Thomas P. Baker, M. Kay Washington, David G. Mutch
Summary: The latest edition of the American Joint Committee on Cancer's TNM staging manual, released in January 2018, will be electronically published chapter by chapter. The first chapter, focusing on cervical cancer staging, has already been released. Changes include incorporating imaging and surgical findings, eliminating lateral spread from T1a, adding a subcategory to T1b (T1b3), and updating histopathology to reflect HPV-associated and HPV-independent carcinomas.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Surgery
Georgios Antonios Margonis, Alessandra Pulvirenti, Vicente Morales-Oyarvide, Stefan Buettner, Nikolaos Andreatos, Carsten Kamphues, Katharina Beyer, Jane Wang, Martin E. Kreis, John L. Cameron, Matthew J. Weiss, Kevin Soares, Carlos Fernandez-del Castillo, Peter J. Allen, Christopher L. Wolfgang
Summary: This study validated the applicability of the 7th and 8th editions of the AJCC staging system for IPMN-associated PDAC. The 8th edition introduced T1a sub-staging and a new distinction between N1 and N2, both of which showed mixed results. The findings support the use of the AJCC 8th edition in the IPMN-associated PDAC population, but suggest that certain cutoffs may need to be revisited.
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Mei-Wen Chen, Hsu-Heng Yen
Summary: This study examined the prognostic predictability of the sixth to eighth editions of the American Joint Committee on Cancer staging system for gastric cancer patients. The sixth edition showed better prognostic stratification, while the seventh and eighth editions had improved homogeneity and discriminatory ability in the T and N staging systems. The overall staging performance of the eighth edition was not superior to the sixth edition, indicating a need for further research with larger sample sizes to compare performance across different ethnic populations.
Review
Oncology
Lauren Janczewski, Joseph Faski, Heidi J. Nelson, Marc Gollub, Cathy D. Eng, James M. Brierley, Joel M. Palefsky, Richard Goldberg, M. Kay A. Washington, Elliot A. Asare, Karyn Goodman
Summary: The American Joint Committee on Cancer (AJCC) staging system is the standard for cancer staging in the United States, and it has been updated to reflect contemporary long-term outcomes for anal cancer. The latest version, AJCC ninth edition, redefines stage IIB and IIIA, and eliminates stage 0 disease from its guidelines.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Endocrinology & Metabolism
Onur Elbasan, Dilek Gogas Yavuz
Summary: This study compared the differences in staging and recurrence prediction between the AJCC 7 and 8 in DTC, and found that AJCC 8 better predicted the recurrence in DTC than AJCC 7.
MINERVA ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Jessica J. Waninger, Vincent T. Ma, Sara Journey, Jeremy Skvarce, Zoey Chopra, Alangoya Tezel, Alex K. Bryant, Charles Mayo, Yilun Sun, Kamya Sankar, Nithya Ramnath, Christopher Lao, Jeremy B. Sussman, Leslie Fecher, Ajjai Alva, Michael D. Green
Summary: This study found that the AJCC eighth edition M category was poorly reflective of prognosis in patients receiving ICIs. Future staging systems could consider emphasizing the presence of liver metastases and elevated LDH levels. Additional studies are needed to confirm the importance of these and other prognostic biomarkers.
Article
Oncology
Thijs J. Schouten, Lois A. Daamen, Galina Dorland, Stijn R. van Roessel, Vincent P. Groot, Marc G. Besselink, Bert A. Bonsing, Koop Bosscha, Lodewijk A. A. Brosens, Olivier R. Busch, Ronald M. van Dam, Arantza Farina Sarasqueta, Sebastiaan Festen, Bas Groot Koerkamp, Erwin van der Harst, Ignace H. J. T. de Hingh, Martijn Intven, Geert Kazemier, Vincent E. de Meijer, Vincent B. Nieuwenhuijs, G. Mihaela Raicu, Daphne Roos, Jennifer M. J. Schreinemakers, Martijn W. J. Stommel, M. F. van Velthuysen, Robert C. Verdonk, Joanne Verheij, Helena M. Verkooijen, Hjalmar C. van Santvoort, I. Quintus Molenaar
Summary: This study aimed to validate five proposed modifications to the 8th American Joint Committee on Cancer (AJCC) TNM staging system for pancreatic ductal adenocarcinoma. The results showed that the 8th edition still lacks prognostic value for some categories of patients, and the four previously proposed modifications did not clearly improve the situation. However, a new modification suggested in this study allows for better prognostication in patients with all stages of the disease.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Ophthalmology
Shichong Jia, Tianyu Zhu, Hanhan Shi, Chunyan Zong, Yongyang Bao, Xuyang Wen, Shengfang Ge, Jing Ruan, Shiqiong Xu, Renbing Jia, Xianqun Fan
Summary: This study examined the predictive value of the tumor staging system and histologic features in conjunctival melanoma patients. The findings revealed that most patients presented with advanced stages and high rates of distant metastasis, with features like tumor thickness and ulceration being correlated with distant metastasis.
Article
Ophthalmology
Shichong Jia, Tianyu Zhu, Hanhan Shi, Chunyan Zong, Yongyang Bao, Xuyang Wen, Shengfang Ge, Jing Ruan, Shiqiong Xu, Renbing Jia, Xianqun Fan
Summary: This retrospective study on conjunctival melanoma patients revealed that higher cT category was associated with increased risks of distant metastasis and disease-specific death. The study also identified previously unreported mutations in tumor suppressor genes.
Article
Ophthalmology
Roisin R. Reynolds, Michael J. Davies, Frank Buffam, Peter J. Dolman, Valerie A. White
Summary: This study examined the clinicopathological features of periocular sebaceous carcinoma and highlighted significant differences in T categories between the seventh and eighth editions of the AJCC staging system in a Canadian population. The findings revealed a high number of patients with small tumors at presentation and few recurrences or metastases in the study population.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Gastroenterology & Hepatology
Marek Sierzega, Lukasz Bobrzynski, Piotr Kolodziejczyk, Grzegorz Wallner, Jan Kulig, Antoni Szczepanik, M. Sierzega, L. Bobrzynski, P. Kolodziejczyk, G. Wallner, J. Kulig, A. Szczepanik, J. Dadan, M. Drews, M. Fraczek, A. Jeziorski, M. Krawczyk, T. Starzynska, P. Richter
Summary: A prognostic nomogram was developed for gastric cancer patients with inadequate counts of evaluated lymph nodes. The nomogram showed better accuracy and discriminatory power in predicting 5-year survival compared to the previous staging systems, and was validated in two Western populations.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Tao He, Ruo-Nan Yan, Hua-Ying Chen, Yuan-Yuan Zeng, Zhong-Zheng Xiang, Fang Liu, Bian-Fei Shao, Jia-Chun Ma, Xi-Ran Wang, Lei Liu
Summary: The 8th edition of the UICC/AJCC staging system has shown superior prognostic value in nonmetastatic nasopharyngeal carcinoma patients treated with SIB-IMRT compared to the 7th edition.
Article
Oncology
Dong Tian, Kai-Yuan Jiang, Yu-Shang Yang, Hao-Ji Yan, Rui-Xuan Yu, Heng Huang, Shun-Hai Jian, Hai-Ning Zhou, Hong-Ying Wen, Long-Qi Chen
Summary: This study aimed to investigate the prognosis of lymph node metastasis (LNM) in esophageal squamous cell carcinoma (ESCC) and propose a novel N (nN) staging system. It was found that paradigestive LNM was associated with worse overall survival (OS) compared to pararespiratory LNM. The nN staging system showed superior prognostic ability than current N staging systems.
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)