Article
Engineering, Biomedical
Harshita Narang, Bruno V. Rego, Amir H. Khalighi, Ahmed Aly, Alison M. Pouch, Robert C. Gorman, Joseph H. Gorman III, Michael S. Sacks
Summary: Research shows that there are significant differences in pre-surgical mitral valve size, shape, and deformation patterns between patients with and without IMR recurrence at 6 months post-surgery. Average pre-surgical circumferential leaflet strain in the A1 region can independently predict IMR recurrence.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biology
Yousef Alharbi, Amr Al Abed, Azam Ahmad Bakir, Nigel H. Lovell, David W. M. Muller, James Otton, Socrates Dokos
Summary: A 3D fluid structure interaction computational model was developed to simulate the interaction between bileaflet mitral valve and blood flow in the left ventricle. The model successfully reproduced the physiological opening and closing of the mitral valve leaflets and simulated normal and prolapsed valve states. Additionally, it simulated blood flow patterns after the insertion of a prosthetic valve with and without obstruction of left ventricular outflow tract flow.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yusuke Misumi, Satoshi Kainuma, Koichi Toda, Shigeru Miyagawa, Daisuke Yoshioka, Atsushi Hirayama, Tetsuhisa Kitamura, Sho Komukai, Yoshiki Sawa
Summary: In patients with nonischemic dilated cardiomyopathy, the mismatch between left ventricular end-systolic dimension and mitral valve ring size is associated with an increased risk of recurrent mitral regurgitation after restrictive mitral annuloplasty. This finding may have implications for surgical strategies in these patients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Karl-Andreas Dumont, Hans Martin Dahl Aguilera, Robert Persson, Victorien Prot, John-Peder Escobar Kvitting, Stig Urheim
Summary: The onset and severity of late systolic regurgitation in Barlow's mitral valve disease are determined by annulus dynamics and mechanical stresses imposed by the left ventricle. Annulus dilatation may accentuate mitral valve regurgitation, and a novel annulus elastance index can predict the severity of regurgitation.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Computer Science, Artificial Intelligence
Ahmed H. Aly, Pulkit Khandelwal, Abdullah H. Aly, Takayuki Kawashima, Kazuki Mori, Yoshiaki Saito, Judy Hung, Joseph H. Gorman, Alison M. Pouch, Robert C. Gorman, Paul A. Yushkevich
Summary: This study develops and validates a fully automated algorithm for segmentation and shape modeling of the left ventricular mitral valve complex from pre-operative 3D transesophageal echocardiography. The algorithm achieves accurate results and provides support for surgical decision making for patients with ischemic mitral regurgitation.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Mikiko Senzai, Satoshi Kainuma, Koichi Toda, Shigeru Miyagawa, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yusuke Misumi, Takayoshi Ueno, Toru Kuratani, Tetsuhisa Kitamura, Sho Komukai, Kazuhiro Taniguchi, Yoshiki Sawa
Summary: This study aimed to investigate the incidence and determinants of postoperative adverse events in patients with ischemic cardiomyopathy who underwent long-term durable mitral valve repair. The results showed that approximately 50% of the patients died or were hospitalized for heart failure during the 5-year follow-up, even in the absence of recurrent mitral regurgitation. This finding suggests that durable mitral repair does not always lead to favorable clinical outcomes, and adverse events may be associated with volume overload due to impaired renal function and less favorable pulmonary hemodynamics.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Magnus J. Hagnas, Carmelo Grasso, Maria Elena Di Salvo, Anna Caggegi, Marco Barbanti, Salvatore Scandura, Annalisa Milici, Gessica Motta, Agnese Bentivegna, Andrea Sardone, Luigi Capodicasa, Angelo Giuffrida, Fausto Biancari, Timo Makikallio, Davide Capodanno, Corrado Tamburino
Summary: The study aims to investigate how changes in LVEF between admission and discharge affect the long-term outcomes in patients who underwent percutaneous edge-to-edge mitral valve repair. The results show that decreased postprocedural LVEF is associated with increased mortality risk, while improved LVEF is associated with lower mortality risk compared to unchanged LVEF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dongyang Xu, Erin McBride, Kanika Kalra, Keawepono Wong, Robert A. Guyton, Eric L. Sarin, Muralidhar Padala
Summary: Undersizing the mitral annulus with an annuloplasty ring can restore valvular competence, but unphysiologically impair ventricle mechanics. Mitral valve repair strategies should focus not only on restoring valve competence, but preserving ventricle mechanics.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Gediminas Gaidulis, Kirthana Sreerangathama Suresh, Dongyang Xu, Muralidhar Padala
Summary: We developed a patient-specific computational model of the mitral valve using 3D ultrasound images to accurately simulate the pathological valve dynamics. The inclusion of patient-specific boundary conditions was found to be necessary for accurate results, and the use of idealized boundary conditions deviated from the truth dataset. Our approach of using patient-specific boundary conditions for mitral valve modeling is valid.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Popolo Rubbio, Luca Testa, Carmelo Grasso, Antonio Sisinni, Maurizio Tusa, Eustachio Agricola, Federico De Marco, Anna Sonia Petronio, Matteo Montorfano, Rodolfo Citro, Marianna Adamo, Antonio Mangieri, Matteo Casenghi, Anna Lisa Milici, Laura Stazzoni, Antonio Colombo, Corrado Tamburino, Francesco Bedogni
Summary: This study investigated the acute and mid-term outcomes of transcatheter edge-to-edge mitral valve repair (TMVr) with the MitraClip in atrial functional mitral regurgitation (A-FMR). The results showed that MitraClip is a safe and effective option to treat A-FMR in elderly patients, improving their prognosis and leading to positive reverse remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maja-Theresa Dieterlen, Kristin Klaeske, Ricardo Spampinato, Mateo Marin-Cuartas, Karoline Wiesner, Jordan Morningstar, Russell A. Norris, Serguei Melnitchouk, Robert A. Levine, Antonia van Kampen, Michael A. Borger
Summary: Mitral valve prolapse (MVP) not only affects the mitral valve, causing mitral regurgitation, but also leads to maladaptive structural changes in the heart, including regional fibrosis in the left ventricle. Myocardial fibrosis can be quantified with cardiovascular magnetic resonance imaging, but it has its limitations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Gediminas Gaidulis, Muralidhar Padala
Summary: Surgical repair of functional mitral regurgitation (FMR) is challenging due to heterogeneity in valve geometry, and predictive models for planning this surgery are lacking. This study presents a 3D echo-derived computational model to enable subject-specific pre-surgical planning. Results show that large annuloplasty rings (>32 mm) are not effective in eliminating regurgitant gaps or restoring leaflet coaptation, while smaller rings (≤32 mm) restore better systolic valve closure but still have limitations. The study demonstrates the importance of individualized corrections and avoiding excessive annular reduction.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
K. Carlos El-Tallawi, Danai Kitkungvan, Jiaqiong Xu, Vittorio Cristini, Eric Y. Yang, Miguel A. Quinones, Gerald M. Lawrie, William A. Zoghbi, Dipan J. Shah
Summary: The study found that in patients with Barlow disease, despite similar transvalvular mitral regurgitation, those with larger prolapse volume had larger left ventricular end-diastolic volume and total volume load. Increasing prolapse volume and mitral regurgitation led to incremental increase in left ventricular end-diastolic volume in Barlow disease patients.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Kyoung-Woon Joung, Seon-Ok Kim, Jae-Sik Nam, Young-Jin Moon, Hyeun-Joon Bae, Ji-Hyun Chin, Sung-Ho Jung, In-Cheol Choi
Summary: This study investigated the short- and long-term changes in left ventricular ejection fraction (LVEF) after mitral valve repair in patients with chronic primary mitral regurgitation. The results showed that preoperative LVEF and left ventricular end-systolic diameter values can influence the patterns of short- and long-term changes in postoperative LVEF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Varius Dannenberg, Matthias Koschutnik, Carolina Dona, Christian Nitsche, Georg Spinka, Gregor Heitzinger, Katharina Mascherbauer, Andreas Kammerlander, Matthias Schneider-Reigbert, Max-Paul Winter, Philipp Bartko, Georg Goliasch, Christian Hengstenberg, Julia Mascherbauer, Marianne Gwechenberger
Summary: This study observed hemodynamic changes in patients with mitral and tricuspid valve disease after transcatheter valve interventions using CardioMEMS. The results showed that CardioMEMS provides important information for optimizing patient selection and management.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Christina Soncrant, Julia Neily, Sam John T. Sum-Ping, Arthur W. Wallace, Edward R. Mariano, Kay B. Leissner, Peter D. Mills, Lisa Mazzia, Douglas E. Paull
Summary: The VHA's lessons learned project for anesthesia adverse events has proven to be valuable in improving patient safety behavior and preventing adverse events. The majority of respondents found the lessons valuable, shared them with staff, and reported a change in patient safety behavior as a result. Sharing lessons learned provided new knowledge for chiefs and helped in preventing future adverse events.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhongjie Wang, Nick Flores, Matthew Lum, Andrew D. Wisneski, Yue Xuan, Justin Inman, Michael D. Hope, David A. Saloner, Julius M. Guccione, Liang Ge, Elaine E. Tseng
Summary: Finite element analysis revealed that peak wall stresses were overall larger in >= 5.0 cm aTAAs compared to <5.0 cm aTAAs. While there was some correlation between size and peak wall stresses in >= 5.0 cm aTAAs, poor correlation existed in <5.0 cm aTAAs. Patient-specific wall stresses are particularly crucial in determining the risk of dissection for <5.0 cm aTAAs.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Florent Gariel, Wagih Ben Hassen, Gregoire Boulouis, Romain Bourcier, Denis Trystram, Laurence Legrand, Christine Rodriguez-Regent, David Saloner, Catherine Oppenheim, Olivier Naggara, Myriam Edjlali
Article
Clinical Neurology
Michele Porcu, Luigi Cocco, David Saloner, Jasjit S. Suri, Roberto Montisci, Alessandro Carriero, Luca Saba
JOURNAL OF NEUROIMAGING
(2020)
Review
Cardiac & Cardiovascular Systems
Guangming Zhu, Jason Hom, Ying Li, Bin Jiang, Fatima Rodriguez, Dominik Fleischmann, David Saloner, Michele Porcu, Yanrong Zhang, Luca Saba, Max Wintermark
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Wang, Bing Tian, Fei Xiong, Evan Kao, Yue Zhang, Xinke Liu, Xia Tian, Henrik Haraldsson, Chengcheng Zhu, Joseph Leach, Jing Liu, Michael D. Hope, Dimitrios Mitsouras, David Saloner
Summary: Automatic segmentation of non-contrast 3D black blood MRI efficiently provides reproducible morphologic AAA assessment yielding accurate AAA diameters and volumes with no clinically relevant differences compared to either automatic or manual measurements based on CTA.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhang Shi, Jing Li, Ming Zhao, Xuefeng Zhang, Andrew J. Degnan, Mahmud Mossa-Basha, David Saloner, Jianping Lu, Qi Liu, Chengcheng Zhu
Summary: Patients with intracranial atherosclerotic disease (ICAD) have a high frequency of stroke recurrence, and the progression of plaque burden (PB) on HR-MRI is independently associated with recurrent ischemic cerebrovascular events.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph R. Leach, Chengcheng Zhu, Dimitrios Mitsouras, David Saloner, Michael D. Hope
Summary: This study found that there are measurement errors in routine clinical assessment of AAA, with an average clinical measurement inaccuracy of 3.3 mm compared to the MPR method. The clinical use of non-standardized AAA measurement strategies can lead to incorrect classification of AAAs as larger or smaller than the commonly accepted repair threshold of 5.5 cm and can induce large errors in quantification of aneurysm enlargement rate.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Wang, Yue Zhang, Zhaoying Wen, Bing Tian, Evan Kao, Xinke Liu, Wanling Xuan, Karen Ordovas, David Saloner, Jing Liu
Summary: The study introduced a novel method that combines multi-channel deep learning and annular shape level-set approaches for segmenting cardiac MRI images, achieving high accuracy and robustness compared to reference standards and other state-of-the-art methods.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Engineering, Biomedical
Yue Zhang, Vicky Y. Wang, Ashley E. Morgan, Jiwon Kim, Romina Tafreshi, Arthur W. Wallace, Julius M. Guccione, Jonathan W. Weinsaft, Liang Ge, Mark B. Ratcliffe
Summary: A novel method was used in this study to directly measure regional diastolic stiffness in patients after myocardial infarction, which may aid in diagnosing left ventricular diastolic dysfunction. The results showed that using this method, it is possible to calculate diastolic material parameters in different areas of the heart, which helps to more accurately assess the cardiac health status of patients.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vicky Y. Wang, Mehrzad Tartibi, Yue Zhang, Kartiga Selvaganesan, Henrik Haraldsson, Daniel A. Auger, Farshid Faraji, Kimberly Spaulding, Kiyoaki Takaba, Alexander Collins, Esteban Aguayo, David Saloner, Arthur W. Wallace, Jonathan W. Weinsaft, Frederick H. Epstein, Julius Guccione, Liang Ge, Mark B. Ratcliffe
Summary: This study introduces a new kinematic model-based analysis framework for calculating strain from 3D cardiac MRI, which was validated in a gel phantom and applied in sheep models. The KMAF framework allows accurate calculation of LV strain and shows significant spatial variation in healthy and post-MI sheep.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biology
Yue Zhang, Jennifer Adams, Vicky Y. Wang, Lucas Horwitz, Mehrzad Tartibi, Ashley E. Morgan, Jiwon Kim, Arthur W. Wallace, Jonathan W. Weinsaft, Liang Ge, Mark B. Ratcliffe
Summary: This study successfully demonstrated the construction of a biventricular FE mechanics model using hexahedral elements, airbags, and an FMI interface coupled with lumped-parameter circulation models. By simulating PAC and VCO, and calculating LV ESPVR, the study provided insights into the cardiovascular conditions of both healthy volunteers and IHD patients. The results indicate that this co-simulation approach can be applied to study cardiovascular pathologies and device therapies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Barbara A. Cohn, Piera M. Cirillo, Caitlin C. Murphy, Nickilou Y. Krigbaum, Arthur W. Wallace
Summary: This study reports the effectiveness of vaccines against SARS-CoV-2 infection and death in veterans, with a decline in vaccine effectiveness observed for all vaccine types. The decline was greatest for the Janssen vaccine. However, vaccination remained protective against death for individuals who became infected during the Delta variant surge. The study also found variations in the vaccine effectiveness against death among different age groups.
Article
Medicine, General & Internal
Arthur W. Wallace, Piera M. Cirillo, James C. Ryan, Nickilou Y. Krigbaum, Anusha Badathala, Barbara A. Cohn
Summary: This hospital-based observational study found that continuous or initiating use of ACE-I, ARB, and metformin in COVID-19 patients was associated with reduced risk of death, suggesting a possible survival benefit for these medications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Vicky Y. Wang, Mehrzad Tartibi, Yue Zhang, Kartiga Selvaganesan, Henrik Haraldsson, Daniel A. Auger, Farshid Faraji, Kimberly Spaulding, Kiyoaki Takaba, Alexander Collins, Esteban Aguayo, David Saloner, Arthur W. Wallace, Jonathan W. Weinsaft, Frederick H. Epstein, Julius Guccione, Liang Ge, Mark B. Ratcliffe
Summary: The study presented a new kinematic model-based analysis framework for accurate calculation of 3D LV Ecc and Ell, which showed promising validation results and application outcomes.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)