Article
Oncology
Zhicheng He, Zhihua Li, Song Xu, Weibing Wu, Quan Zhu, Jun Wang, Wei Wen, Liang Chen
Summary: This study aimed to identify the optimal number of examined lymph nodes (ELNs) in sublobar resection (SLR) and assess the survival differences between SLR with adequate ELNs and lobectomy. Results showed that SLR patients with an adequate ELN count had noninferior survival outcomes compared with lobectomy patients.
CLINICAL LUNG CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsiu-Ping Chou, Kuan-Hsun Lin, Hsu-Kai Huang, Li-Fan Lin, Ying-Yi Chen, Ti-Hui Wu, Shih-Chun Lee, Hung Chang, Tsai-Wang Huang
Summary: SUVmax was identified as a prognostic factor for resected stage IA NSCLC, providing potential clinical significance. Postoperative treatment may be considered for stage IA3 NSCLC with SUVmax > 4.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jooae Choe, Mi Young Kim, Jae Kwang Yun, Geun Dong Lee, Yong-Hee Kim, Sehoon Choi, Dong Kwan Kim
Summary: This study aimed to identify CT features predictive of pathologic lymphovascular invasion (LVI) in stage IA NSCLC and evaluate their prognostic value in patients undergoing sublobar resection. Pathologic LVI was found only in solid-dominant part-solid nodules and solid nodules with a solid portion diameter over 10 mm. Peritumoral interstitial thickening and pleural contact independently predicted pathologic LVI and recurrence-free survival (RFS) in such nodules.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tingting Wang, Yunlang She, Yang Yang, Xinyue Liu, Shouyu Chen, Yifan Zhong, Jiajun Deng, Mengmeng Zhao, Xiwen Sun, Dong Xie, Chang Chen
Summary: In patients with clinical stage and pathologic stage IA pure-solid non-small cell lung cancer, using a radiomics signature with multiregional features helps stratify the survival risk.
Article
Oncology
Yu Okubo, Jumpei Kashima, Takashi Teishikata, Yuji Muraoka, Masaya Yotsukura, Yukihiro Yoshida, Kazuo Nakagawa, Hirokazu Watanabe, Masahiko Kusumoto, Shun-Ichi Watanabe, Yasushi Yatabe
Summary: Retrospective evaluation of 380 surgically resected pT1 lung adenocarcinomas revealed that lepidic-positive ADCs had lower recurrence rates, but the lepidic component was not an independent prognostic factor.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yasuhiro Tsutani, Kentaro Imai, Hiroyuki Ito, Yoshihiro Miyata, Norihiko Ikeda, Haruhiko Nakayama, Morihito Okada
Summary: This study investigates the efficacy of adjuvant chemotherapy for pathologic stage I non-small cell lung cancer (NSCLC) patients with high risk for recurrence. The results suggest that adjuvant chemotherapy may improve survival in patients with pathologic T1c or T2a or lymphovascular invasion who have high risk factors for recurrence. However, adjuvant chemotherapy does not significantly affect survival in patients without high risk factors.
ANNALS OF THORACIC SURGERY
(2022)
Letter
Medicine, General & Internal
Wilson W. L. Li, Stefan M. van der Heide, Ad F. T. M. Verhagen, Nasser Altorki, Xiaofei Wang, Thomas E. Stinchcombe
Summary: Altorki et al. found similar survival between peripheral stage IA non-small-cell lung cancer patients who underwent lobar resection and those who underwent sublobar resection. However, sublobar resection had a higher incidence of locoregional recurrence, without having the benefits of lower operative mortality, lower risk of complications, higher quality of life, and carrying a probable added risk of adverse events for recurrent disease treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Bin Peng, Guofeng Li, Yanhua Guo
Summary: In patients with early stage lung adenocarcinoma, the presence of non-predominant micropapillary and solid patterns is a risk factor for predicting poor recurrence-free survival.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju G. Nam, Hyunsook Hong, Seung Hong Choi, Chang Min Park, Jin Mo Goo, Young Tae Kim, Hyungjin Kim
Summary: There is no difference in terms of brain metastasis-free survival, time to brain metastasis, and overall survival between asymptomatic patients with clinical stage IA non-small cell lung cancer who underwent staging brain MRI and those who did not.
Article
Oncology
Masaya Yotsukura, Yuji Muraoka, Yukihiro Yoshida, Kazuo Nakagawa, Kouya Shiraishi, Takashi Kohno, Yasushi Yatabe, Shun-ichi Watanabe
Summary: This study found that the prognosis and survival of lung cancer patients after 5 years of surgery were associated with age rather than stage classification. It suggests that the long-term follow-up strategy does not need to be modified based on stage classification, and screening for secondary primary lung cancer should be considered.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ziran Zhao, Yibo Gao, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He
Summary: This study evaluated the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) and found it to be reliable. Surgery was also found to have a significant impact on patients' prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki, Hisashi Saji, Shun-ichi Watanabe
Summary: The study validated the prognostic importance of ground-glass opacity component in clinical stage IA lung cancer and recommended considering it as an important parameter in the next clinical T classification.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Justyna Durslewicz, Anna Klimaszewska-Wisniewska, Jakub Jozwicki, Paulina Antosik, Kamil Kozerawski, Dariusz Grzanka, Marcin Braun
Summary: MATR3 is a nuclear matrix protein involved in mRNA stabilization, nuclear retention of hyper-edited RNAs, and RNA splicing. This study investigates the expression levels and prognostic significance of MATR3 in early-stage non-small cell lung cancer (NSCLC) patients. The study found that the expression of MATR3 protein was significantly higher in tumor-adjacent tissue compared to cancer tissue, while MATR3 mRNA levels were significantly higher in tumor tissue compared to control lung tissues. High levels of MATR3 mRNA were associated with worse overall survival of NSCLC patients. Further investigation is needed to understand the biological and prognostic value of MATR3 as a potential prognostic marker in early-stage NSCLC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Respiratory System
Hyun Woo Jeon, Young-Du Kim, Sung Bo Sim
Summary: Predicting prognosis in stage IA lung adenocarcinoma is complex due to unique characteristics like heterogeneous histologic subtype and ground glass opacity. This study evaluated clinical outcomes for each histologic subtype size in 550 patients, finding that acinar, micropapillary, and solid subtypes had worse prognoses for disease-free interval.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Tatsuro Okamoto, Tetsuzo Tagawa, Yosuke Morodomi, Shinichiro Shimamatsu, Hirokazu Kitahara, Yoshihiko Maehara
THORACIC AND CARDIOVASCULAR SURGEON
(2017)
Article
Multidisciplinary Sciences
Ryota Nakanishi, Hiroyuki Kitao, Mamoru Kiniwa, Yosuke Morodomi, Makoto Iimori, Junji Kurashige, Masahiko Sugiyama, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Taisuke Kanaji, My-Nuong Vo, Sachiko Kanaji, Alessandro Zarpellon, Ryan Shapiro, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Rajesh Belani, Minh-Ha Do, Xiang-Lei Yang, Zaverio M. Ruggeri, Paul Schimmel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Oncology
Takaki Akamine, Yosuke Morodomi, Yui Harada, Koji Teraishi, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshihiko Maehara, Yoshikazu Yonemitsu
ANTICANCER RESEARCH
(2018)
Article
Hematology
Yosuke Morodomi, Sachiko Kanaji, Eric Won, Zaverio M. Ruggeri, Taisuke Kanaji
Article
Oncology
Hirokazu Kitahara, Tatsuro Okamoto, Shinichiro Shimamatsu, Mikihiro Kohno, Yosuke Morodomi, Tetsuzo Tagawa, Hiroyuki Kitao, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara, Masaki Mori
ANTICANCER RESEARCH
(2020)
Article
Cell Biology
Josh Sun, Satoshi Uchiyama, Joshua Olson, Yosuke Morodomi, Ingrid Cornax, Nao Ando, Yohei Kohno, May M. T. Kyaw, Bernice Aguilar, Nina M. Haste, Sachiko Kanaji, Taisuke Kanaji, Warren E. Rose, George Sakoulas, Jamey D. Marth, Victor Nizet
Summary: The study found that decreased platelet count in patients with Staphylococcus aureus infection is associated with increased mortality and increased expression of pathogen toxins. Platelet-derived antibacterial peptides are important in defense against S. aureus, but bacterial toxin can harm platelets and accelerate their clearance.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yosuke Morodomi, Sachiko Kanaji, Brian M. Sullivan, Alessandro Zarpellon, Jennifer N. Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel, Zaverio M. Ruggeri, Taisuke Kanaji
Summary: Platelets play a crucial role in hemostasis, thrombosis, inflammation, and innate immunity. A study found that an activated form of tyrosyl-tRNA synthetase (YRSACT) has extratranslational activity that enhances megakaryopoiesis and platelet production. This study discovered that YRSACT can mimic inflammatory stress and induce a unique population of megakaryocytes with stem cell and myeloid markers, relying on Toll-like receptor activation and type I interferon signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My-Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang-Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Yosuke Morodomi, Sachiko Kanaji, Eric Won, Tadafumi Kawamoto, Taisuke Kanaji
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Medicine, Research & Experimental
Tine Wyseure, Tingyi Yang, Jenny Y. Zhou, Esther J. Cooke, Bettina Wanko, Merissa Olmer, Ruchi Agashe, Yosuke Morodomi, Niels Behrendt, Martin Lotz, John Morser, Annette von Drygalski, Laurent O. Mosnier
Article
Hematology
Sachiko Kanaji, Jennifer N. Orje, Taisuke Kanaji, Yuichi Kamikubo, Yosuke Morodomi, Yunfeng Chen, Alessandro Zarpellon, Jerome Eberhardt, Stefano Forli, Scot A. Fahs, Rashmi Sood, Sandra L. Haberichter, Robert R. Montgomery, Zaverio M. Ruggeri
Article
Oncology
Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara
Letter
Oncology
Yosuke Morodomi, Tatsuro Okamoto, Yoshihiko Maehara
ANNALS OF SURGICAL ONCOLOGY
(2017)
Article
Oncology
Tatsuro Okamoto, Mikihiro Kohno, Kensaku Ito, Kazuki Takada, Masakazu Katsura, Yosuke Morodomi, Gouji Toyokawa, Fumihiro Shoji, Yoshihiko Maehara
ANTICANCER RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)