Article
Cardiac & Cardiovascular Systems
Anna Reka Kiss, Zsofia Gregor, Adrian Popovics, Kinga Grebur, Liliana Erzsebet Szabo, Zsofia Dohy, Attila Kovacs, Balint Karoly Lakatos, Bela Merkely, Hajnalka Vago, Andrea Szucs
Summary: This study aimed to investigate the involvement of the right ventricle (RV) in left ventricular non-compaction (LVNC) patients. The results showed that RV involvement was present in LVNC patients, with higher RV volumes, poorer RV function, and the presence of RV non-compaction. RV non-compaction was correlated with RV volume and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alda Bregasi, James Freeman, Jeptha P. Curtis, Joseph G. Akar, Xochitl A. Ortiz-Leon, Julia H. Maia, Angela Y. Higgins, Ray Matthews, Albert J. Sinusas, Robert L. McNamara, Lissa Sugeng, Ben A. Lin
Summary: Our study reveals that left atrial stiffness significantly increases after endocardial left atrial appendage occlusion, and baseline left atrial appendage size is associated with the magnitude of the increase and left atrial body stiffness.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Micheal Naguib, Mostafa Elsayed, Rami Nadim Khouzam, Ayman Iskander
Summary: Left ventricular pseudoaneurysm is a known complication of myocardial infarction and open-heart surgery, and recently has been observed after transapical transcatheter aortic valve replacement. While surgery is the usual treatment approach, transcatheter closure can be considered for high-risk patients. This article presents a case of post-myocardial infarction pseudoaneurysm closed via retrograde left ventricular access using an Amplatzer Septal Occluder, and reviews recent literature on indications and outcomes of different percutaneous techniques and devices.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aung Myat, Mihir Patel, John Silberbauer, David Hildick-Smith
Summary: This study found that IRA-CTO PCI may positively modify the size and composition of myocardial scar associated with rVT in patients with ischemic cardiomyopathy, potentially reducing the occurrence of recurrent ventricular tachycardia.
Article
Cardiac & Cardiovascular Systems
Ezequiel Molina, Amiti Jain, Sara Ahmed, Phillip Lam, Sriram Rao, Michael Hockstein, Ajay Kadakkal, Mark Hofmeyer, Maria Rodrigo, JiLing Chou, Samer Najjar, Farooq Sheikh
Summary: This study found that smaller preoperative left ventricular end-diastolic dimension (LVEDD) (<=59 mm) in patients receiving a centrifugal-flow LVAD was associated with lower survival and higher incidence of adverse outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Yuji Shigematsu, Shuntaro Ikeda, Kiyotaka Ohshima, Akiyoshi Ogimoto
Summary: Cibenzoline treatment significantly reduced cardiovascular complications and death, especially due to LVHF, in patients with HOCM. LV reverse remodelling was confirmed in Group A, while LV remodelling advanced in Group B.
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Yuji Shigematsu, Shuntaro Ikeda, Kiyotaka Ohshima, Akiyoshi Ogimoto
Summary: The study aimed to clarify the long-term effect of cibenzoline therapy on cardiovascular complications and prognosis in patients with hypertrophic obstructive cardiomyopathy (HOCM). It was found that cibenzoline treatment significantly reduced all cardiovascular complications and death due to LVHF, making it a promising treatment for patients with HOCM.
Article
Biophysics
K. L. P. M. Janssens, M. Kraamer, L. Barbarotta, P. H. M. Bovendeerd
Summary: Adverse ventricular remodeling following acute myocardial infarction can lead to ventricular dilation, fibrosis, and loss of contractile function, which may result in heart failure. Understanding the relationship between the material properties of the myocardium and heart function over time can help in developing novel therapies for post-MI heart failure.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Sophie Juul, Kasper Kyhl, Kathrine Ekstr, Jasmine Melissa Madsen, Muhammad Sabbah, Kiril Aleksov Ahtarovski, Lars Nepper-Christensen, Niels Vejlstrup, Dan Hofsten, Henning Kelbaek, Lars Kober, Jacob Lonborg, Thomas Engstrom
Summary: Mounting evidence shows that right ventricle (RV) function carries independent prognostic influence in various disease states. This study investigated the incidence and impact of permanent RV infarction in patients with inferior ST-segment elevation myocardial infarction (STEMI) and culprit lesion in the right coronary artery (RCA). The results revealed that permanent RV infarction occurred in 20% of these patients and independently predicted the size of the final left ventricular infarct.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Erdei, J. C. L. Rodrigues, R. Hartley-Davies, A. G. Dastidar, G. V. Szantho, E. C. Hart, A. K. Nightingale, N. E. Manghat, M. C. K. Hamilton
Summary: This study assessed the relationship between global longitudinal strain and left atrial and left ventricular filling and emptying. In hypertensive patients, reduced global longitudinal strain was associated with impaired left atrial function and impaired left ventricular filling and diastolic function.
CLINICAL RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rienzi A. A. Diaz-Navarro, Peter L. M. Kerkhof
Summary: Left ventricular global function index (LVGFI) is a volume-based composite metric for evaluating ventricular function, with serious limitations that require evaluation at both mathematical and clinical levels. LVGFI is mathematically coupled to both ejection fraction (EF) and ventriculo-arterial coupling (VAC), sharing similar prognostic values and shortcomings. Sex-specific differences were observed in companion metrics, indicating incremental value compared to single-use metrics in characterizing patient groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Article
Biotechnology & Applied Microbiology
Cemre Celikbudak Orhon, Nikolaos Stergiopulos, Stephane Noble, Georgios Giannakopoulos, Hajo Muller, Dionysios Adamopoulos
Summary: The transaortic valvular pressure gradient (TPG) is important for decision-making in severe aortic stenosis patients. However, the flow-dependence nature of TPG makes diagnosis challenging. A mathematical model was used to assess the independent effects of left ventricular performance and afterload on TPG in different levels of aortic stenosis. In patients with critical aortic stenosis, the increase of end-diastolic elastance had the most significant effect on TPG, followed by end-systolic elastance, total arterial compliance, and total vascular resistance. The interdependence of TPG, left ventricular performance, and afterload becomes stronger with increased aortic stenosis severity.
BIOENGINEERING-BASEL
(2023)
Article
Cardiac & Cardiovascular Systems
Xavier Galloo, Jan Stassen, Kensuke Hirasawa, Surenjav Chimed, Bernard Cosyns, Nina Ajmone Marsan, Victoria Delgado, Pieter van der Bijl, Jeroen J. Bax
Summary: This study evaluates the impact of baseline LV volumes on LV reverse remodeling after cardiac resynchronization therapy (CRT) and its association with improved survival. The results demonstrate that many patients with larger baseline LV volumes still show significant LV reverse remodeling after CRT and have better survival, regardless of baseline LV volumes. CRT should not be denied based on severe LV dilatation.
Review
Cardiac & Cardiovascular Systems
Micheal Naguib, Mostafa Elsayed, Rami Nadim Khouzam, Ayman Iskander
Summary: Left ventricular pseudoaneurysms are known complications of myocardial infarction and open-heart surgery, and can also occur after transapical transcatheter aortic valve replacement. While surgical intervention is the conventional treatment approach, percutaneous closure can be considered in high-risk patients. This article presents a case of post-myocardial infarction pseudoaneurysm that was successfully closed using retrograde left ventricular access and an Amplatzer Septal Occluder device, and provides a review of recent literature on indications and outcomes of different percutaneous techniques.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy R. McGarvey, Norihiro Kondo, Walter R. T. Witschey, Manabu Takebe, Chikashi Aoki, Jason A. Burdick, Francis G. Spinale, Joseph H. Gorman, James J. Pilla, Robert C. Gorman
ANNALS OF THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
James J. Pilla, Kevin J. Koomalsingh, Jeremy R. McGarvey, Walter R. T. Witschey, Larry Dougherty, Joseph H. Gorman, Robert C. Gorman
ANNALS OF THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Francisco J. Contijoch, Walter R. T. Witschey, Jeremy McGarvey, Madonna E. Lee, Joseph Gorman, Robert C. Gorman, James J. Pilla
ANNALS OF THORACIC SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
Christopher B. Rodell, Madonna E. Lee, Hua Wang, Satoshi Takebayashi, Tetsushi Takayama, Tomonori Kawamura, Jeffrey S. Arkles, Neville N. Dusaj, Shauna M. Dorsey, Walter R. T. Witschey, James J. Pilla, Joseph H. Gorman, Jonathan F. Wenk, Jason A. Burdick, Robert C. Gorman
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2016)
Article
Computer Science, Interdisciplinary Applications
Amir Nikou, Shauna M. Dorsey, Jeremy R. McGarvey, Joseph H. Gorman, Jason A. Burdick, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2016)
Article
Biophysics
Hua Wang, Xiaoyan Zhang, Shauna M. Dorsey, Jeremy R. McGarvey, Kenneth S. Campbell, Jason A. Burdick, Joseph H. Gorman, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francisco Contijoch, Srikant Kamesh Iyer, James J. Pilla, Paul Yushkevich, Joseph H. Gorman, Robert C. Gorman, Harold Litt, Yuchi Han, Walter R. T. Witschey
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Biophysics
Reza Avazmohammadi, Joao S. Soares, David S. Li, Thomas Eperjesi, James Pilla, Robert C. Gorman, Michael S. Sacks
JOURNAL OF BIOMECHANICS
(2020)
Article
Multidisciplinary Sciences
Brianna F. Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P. Solomon, Anya T. Hall, Rishabh Kumar, Nicholas J. Josselyn, Elizabeth M. Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Cory Tschabrunn, Samuel J. Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W. Wehrli, Haochang Shou, Victor A. Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai, Walter R. Witschey
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Francisco Contijoch, Yuchi Han, Srikant Kamesh Iyer, Peter Kellman, Gene Gualtieri, Mark A. Elliott, Sebastian Berisha, Joseph H. Gorman, Robert C. Gorman, James J. Pilla, Walter R. T. Witschey
Article
Radiology, Nuclear Medicine & Medical Imaging
Brianna F. Moon, Srikant Kamesh Iyer, Nicholas J. Josselyn, Eileen Hwuang, Sophia Swago, Samuel J. Keeney, Estibaliz Castillero, Giovanni Ferrari, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Cory M. Tschabrunn, Haochang Shou, William Matthai, Felix W. Wehrli, Victor A. Ferrari, Yuchi Han, Harold Litt, Walter R. Witschey
Summary: The study compared Delta chi and R2* in subacute myocardial infarction at 3T and 7T, finding that magnetic susceptibility did not significantly differ across field strengths, while R2* showed a significant difference. The study concluded that R2* was dependent on field strength, while Delta chi showed independence, with histology validating the presence of iron and supporting imaging findings.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
G. Pilla, M. Levack, J. Mcgarvey, E. Hwuang, G. Zsido, J. Gorman, J. Pilla, W. R. Witschey, R. Gorman
Summary: This study evaluated the effects of ischemic mitral regurgitation (IMR) on vortex formation and leaflet dynamics using a porcine infarct model. IMR caused asymmetric vortex ring formation, while normal ventricles created symmetric vortices underneath the mitral leaflets. IMR animals showed delayed peak vorticity and leaflet opening compared to control animals.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2021)
Correction
Cardiac & Cardiovascular Systems
Rutger H. Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Walter R. T. Witschey
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2017)
Article
Cardiac & Cardiovascular Systems
Rutger H. Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Walter R. T. Witschey
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2017)
Article
Engineering, Biomedical
Amir Nikou, Shauna M. Dorsey, Jeremy R. McGarvey, Joseph H. Gorman, Jason A. Burdick, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk
ANNALS OF BIOMEDICAL ENGINEERING
(2016)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)