Review
Biochemistry & Molecular Biology
Negar Mir, Shannon A. Chin, Michael C. Riddell, Jacqueline L. Beaudry
Summary: Glucocorticoids (GCs) help the body cope with stress by regulating glucose and free fatty acids, maintaining energy homeostasis in multiple tissues. The genomic and non-genomic effects of GCs in adipose tissue play a crucial role in modulating lipid metabolism and have implications for the treatment of adipose-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Gaetano Caramori, Francesco Nucera, Sharon Mumby, Federica Lo Bello, Ian M. Adcock
Summary: Inhaled glucocorticoids (GCs) are widely used to treat asthma patients. They prevent the activation of immune and inflammatory cells in the lungs and have significant effects on airway structure. However, some patients show poor asthma control even with high doses of GCs, which may be due to GC resistance.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Review
Immunology
Drishti Tiwari, Pawan Gupta
Summary: The improvement in living standards and adoption of Western lifestyle has led to increased burden of allergies and asthma in both developed and developing countries. Research shows a link between allergic diseases and metabolic dysfunction, emphasizing the importance of organized lifestyle and dietary habits. Nuclear receptors have been at the forefront of the pharmacy world historically, playing a crucial role in modulating asthma pharmacology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Olulade A. Ayodele, Howard J. Cabral, David D. McManus, Susan S. Jick
Summary: This study evaluated the risk of VTE associated with the use of glucocorticoids in patients with asthma. The results showed that current and systemic glucocorticoid use was associated with a dose-response increased risk of incident VTE.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Biochemical Research Methods
Tuomas Karvonen, Anna Sepponen-Lavikko, Kati Holm, Rudiger Schultz, Eeva Moilanen, Lauri Lehtimaki
Summary: The study found that ICS treatment rapidly reduced FENO50 and J(aw)NO, likely due to the decrease in bronchial wall NO concentration while bronchial NO diffusion factor remained unchanged. This suggests that CawNO may be a more specific marker of airway inflammation and treatment response.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Chemistry, Medicinal
Flavia Giordano, Angela Corvino, Antonia Scognamiglio, Valentina Citi, Era Gorica, Caterina Fattorusso, Marco Persico, Giuseppe Caliendo, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Rocco Carmelo Pavese, Francesco Petti, Alma Martelli, Vincenzo Calderone, Francesco Frecentese
Summary: The newly synthesized hybrids with H2S-donor moieties have shown promise in treating asthma by enhancing drug efficacy and reducing toxicity. These compounds modulate multiple targets and release H2S, resulting in inhibiting cell degranulation and inducing cell membrane hyperpolarization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Allergy
Natalia Weare-Regales, Stephanie N. Hudey, Richard F. Lockey
Summary: Osteoporosis is a serious condition with dire consequences, especially in individuals using glucocorticoids longterm. Management strategies for prevention and treatment are tailored to different age groups, emphasizing the importance of peak bone mass attainment and fracture risk assessment in adults. Additional expertise is recommended for complicated cases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
P. Jane McDowell, John H. Stone, Yuqing Zhang, Kirsty Honeyford, Louise Dunn, R. Jayne Logan, Claire A. Butler, Lorcan P. A. McGarvey, Liam G. Heaney
Summary: The GTI is a useful tool for systematically capturing and quantifying GC toxicity at the individual patient level in severe asthma. GC toxicity varies widely between individual patients with SA and correlates only modestly with GC exposure over the preceding year. Age and mini-AQLQ are better predictors of GC toxicity. The GTI and MCID will facilitate assessment of individual SA response to steroid-sparing agents in clinical trials and routine care.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Immunology
Huan Dai, Rongying Zheng, Like Wang, Jinyi Wan, Yu Tong, Wei Zhao, Weixi Zhang
Summary: The study demonstrates that ICS/LABA and SCIT therapies can significantly improve the Th17/Treg imbalance in asthma patients, reducing the percentage of Th17 cells and serum IL-17A levels, while increasing the proportion of Treg cells. These findings suggest new approaches for treating asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
M. Gurnell, L. G. Heaney, D. Price, A. Menzies-Gow
Summary: Secondary adrenal insufficiency often results from excessive exogenous corticosteroid therapy, particularly oral corticosteroids. Biologic therapies offer a potential solution for reducing or eliminating maintenance OCS in severe asthma, but there is a need for further clinical trials to define strategies for early identification and treatment of AI, as well as safe OCS withdrawal in routine practice.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Respiratory System
Fien Gysens, Pieter Mestdagh, Eric de Bony de Lavergne, Tania Maes
Summary: This review focuses on the study of long non-coding RNAs (lncRNAs) in asthma. The research finds that many lncRNAs are differentially expressed in asthma and are associated with asthma severity or inflammatory phenotype. Moreover, the mechanisms of action of specific lncRNAs have been identified through in vivo and in vitro functional studies.
Article
Pharmacology & Pharmacy
Inge Raadal Skov, Daniel Pilsgaard Henriksen, Hanne Madsen, Anton Pottegard, Jesper Romhild Davidsen
Summary: From 1999 to 2018, the prevalence of OCS users among young adults with active asthma in Denmark has remained relatively stable, with a decrease in high-users and annual consumption.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Allergy
Akke-Nynke van der Meer, Kim de Jong, Michiel Ferns, Christine Widrich, Anneke ten Brinke
Summary: The study revealed that 7.2% of Dutch asthma patients were overexposed to oral corticosteroids, with only about half of them using adequate doses of inhaled corticosteroids and 40.3% not receiving specialist intervention within the previous 3 years.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Multidisciplinary Sciences
Carolyn J. Hogg, Kym Ottewell, Peter Latch, Maurizio Rossetto, James Biggs, Andrew Gilbert, Sarah Richmond, Katherine Belov
Summary: Globally, less than 3% of threatened animal species have genomic resources for conservation management. To address this, a consortium in Australia launched the Threatened Species Initiative to develop genomic data and tools for conservation practitioners. The objective is to empower conservation practitioners to access and apply genomic data to their decision-making processes through a web-based portal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Allergy
Tong Yu, Yiping Yu, Yingyu Ma, Guoqing Chen
Summary: Inhibition of CREB promotes ferroptosis of eosinophils in pediatric asthma, enhancing the anti-inflammatory effect of glucocorticoids on airway inflammation.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)