Article
Critical Care Medicine
Elizabeth R. Volkmann, Donald P. Tashkin, Michael D. Roth, Jonathan Goldin, Grace H. J. Kim
Summary: This study demonstrates that short-term changes in radiographic measures of interstitial lung disease (ILD) can predict long-term survival in patients with systemic sclerosis (SSc), indicating that radiographic end points may serve as surrogates for mortality in SSc-ILD.
Article
Clinical Neurology
Jeff Ehresman, Andrew Schilling, Xinghai Yang, Zach Pennington, Ali Karim Ahmed, Ethan Cottrill, Daniel Lubelski, Majid Khan, Kendall F. Moseley, Daniel M. Sciubba
Summary: This study aimed to evaluate whether the MRI-derived VBQ score can predict fragility fractures in high-risk patients, and the results showed a significant association between VBQ score and fragility fractures, which outperformed the predictive value of DXA bone mineral density measurement.
Article
Neuroimaging
Samantha Abram, Brian J. Roach, Jessica P. Y. Hua, Laura K. M. Han, Daniel H. Mathalon, Judith M. Ford, Susanna L. Fryer
Summary: This study found a correlation between brain aging and emotional well-being in individuals with schizophrenia, with younger-looking brains being associated with better emotional well-being. This relationship persisted even after controlling for age, clinical variables, etc.
NEUROIMAGE-CLINICAL
(2023)
Article
Rheumatology
Desiree van der Heijde, Mikkel Ostergaard, John D. Reveille, Xenofon Baraliakos, Andris Kronbergs, David M. Sandoval, Xiaoqi Li, Hilde Carlier, David H. Adams, Walter P. Maksymowych
Summary: This study evaluates the long-term effect of IXE on radiographic changes in the spine in patients with r-axSpA and identifies potential predictors of progression. The majority of patients had no radiographic progression in the spine through 2 years of treatment.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Critical Care Medicine
Morgan E. McKeown, Ayush Prasad, Jessica Kobsa, Ilayda Top, Samuel B. Snider, Chelsea Kidwell, Bruce C. V. Campbell, Stephen M. Davis, Geoffrey A. Donnan, Michael Lev, Kevin N. Sheth, Nils Petersen, W. Taylor Kimberly, Matthew B. Bevers
Summary: The study found that a midline shift (MLS) greater than 3 mm is an important threshold for predicting poor outcomes in patients with acute stroke.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
Sophie I. J. van Bakel, Hester A. Gietema, Patricia M. Stassen, Harry R. Gosker, Debbie Gach, Joop P. van den Bergh, Frits H. M. van Osch, Annemie M. W. J. Schols, Rosanne J. H. C. G. Beijers
Summary: This study found that CT scan-derived low pectoralis muscle CSA is significantly associated with higher 30-day in-hospital mortality in patients with COVID-19 independently of the 4C Mortality Score.
Article
Clinical Neurology
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Cecile Tissot, Isabelle Rivals, Philippe Gervais, Fabien Caille, Martin Moussion, Michel Bottlaender, Marie Sarazin
Summary: Based on the study findings, tau tracer binding in specific brain regions is strongly associated with cognitive decline in patients with Alzheimer's disease (AD). In contrast, initial amyloid load, regional cortical atrophy or CSF biomarkers do not show significant relationship with cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Oncology
Maxime Jullien, Benoit Tessoulin, Herve Ghesquieres, Lucie Oberic, Franck Morschhauser, Herve Tilly, Vincent Ribrag, Thierry Lamy, Catherine Thieblemont, Bruno Villemagne, Remy Gressin, Kamal Bouabdallah, Corinne Haioun, Gandhi Damaj, Luc-Matthieu Fornecker, Jean-Marc Schiano De Colella, Pierre Feugier, Olivier Hermine, Guillaume Cartron, Christophe Bonnet, Marc Andre, Clement Bailly, Rene-Olivier Casasnovas, Steven Le Gouill
Summary: A CT segmentation algorithm based on convolutional neural networks was developed to assess body composition of DLBCL patients and predict mortality risk. Muscle hypodensity was found to be an independent risk factor for mortality in this population and can be estimated at diagnosis using this new tool.
Article
Clinical Neurology
Qian Chen, Youwei Ai, Yong Huang, Qiujiang Li, Juehan Wang, Hong Ding, Ce Zhu, Ganjun Feng, Limin Liu
Summary: Assessing the endplate bone quality using MRI-based EBQ scores can predict the risk of cage subsidence following TLIF surgery.
Article
Neurosciences
Giulia Coarelli, Frederic Darios, Emilien Petit, Karim Dorgham, Isaac Adanyeguh, Elodie Petit, Alexis Brice, Fanny Mochel, Alexandra Durr
Summary: This study found that in autosomal dominant spinocerebellar ataxias (SCAs), NfL levels can better predict clinical manifestations and brain changes. Additionally, NfL levels may help refine inclusion criteria for carriers in clinical trials.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Hui Lin, Haojie Wang, Yawen Xu, Zhangya Lin, Dezhi Kang, Shufa Zheng, Peisen Yao
Summary: The study found that elderly patients with ruptured intracranial aneurysm who developed cerebral infarction had lower admission body temperature, higher prevalence of hypertension and diabetes, and worse outcomes. There was a negative correlation between admission body temperature and cerebral infarction, with 36.6 degrees Celsius identified as a critical value for predicting infarction.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
David Bachinger, Bernhard Schuknecht, Julia Dlugaiczyk, Andreas H. Eckhard
Summary: Bilateral progression of Meniere's disease correlates with radiological markers of endolymphatic sac hypoplasia. With over two-thirds of patients progressing bilaterally, this predictive tool may become a crucial guide for future therapeutic management.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rheumatology
Rongjie Wu, Guangtao Fu, Mengyuan Li, Yuanchen Ma, Qingtian Li, Zhantao Deng, Qiujian Zheng
Summary: The severity of contralateral knee osteoarthritis (OA) is associated with the progression of ipsilateral knee with early OA. Ipsilateral knee with early-stage OA has worse prognosis when contralateral knee has advanced OA.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Sofia Ramiro, Robert Landewe, Desiree van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J. Carter Thorne, Maggie J. Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G. Cantagrel, Cornelia F. Allaart, Cheryl Barnabe, Clifton O. Bingham III, Dirkjan van Schaardenburg, Hilde B. Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P. Maksymowych
Summary: The study investigates whether meticulously following a treat-to-target (T2T) strategy in daily clinical practice leads to less radiographic progression in patients with active rheumatoid arthritis (RA). The findings show that a more stringent application of T2T does not result in less radiographic progression compared to a somewhat lenient attitude towards T2T.
Article
Clinical Neurology
Charidimos Tsagkas, Yvonne Naegelin, Michael Amann, Athina Papadopoulou, Christian Barro, M. Mallar Chakravarty, Laura Gaetano, Jens Wuerfel, Ludwig Kappos, Jens Kuhle, Cristina Granziera, Till Sprenger, Stefano Magon, Katrin Parmar
Summary: This study evaluated the potential of short-term MRI measures and serum neurofilament light chain as predictors of disability accumulation dynamics in multiple sclerosis patients, showing their ability to accurately predict future disability progression. Factors such as spinal cord atrophy rates, lesion load increase, baseline thalamic volumes, striatal volumes, and sNfL were found to be related to future disability worsening.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Rheumatology
Morten B. Pedersen, Peter Thinggaard, Rinie Geenen, Marianne U. Rasmussen, Maarten De Wit, Lyn March, Philip Mease, Ernest Choy, Philip G. Conaghan, Lee Simon, Anne Faber Hansen, Simon Tarp, Berit Schiottz-Christensen, Carsten B. Juhl, Sabrina M. Nielsen, Kirstine Amris, Robin Christensen
Summary: Biopsychosocial rehabilitation has a significant but clinically small beneficial effect on pain relief among patients with inflammatory arthritis and osteoarthritis (OA), with no difference in harm.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Geriatrics & Gerontology
Swati Chopra, Rama T. Kodali, Gretl A. McHugh, Philip G. Conaghan, Sarah R. Kingsbury
Summary: This scoping review summarizes the evidence related to home-based health care interventions for older adults with chronic musculoskeletal pain. The findings suggest that physical therapy, psychotherapy, and multimodal therapy are effective self-management options.
JOURNAL OF GERIATRIC PHYSICAL THERAPY
(2023)
Article
Rheumatology
P. G. Conaghan, L. Abraham, L. Viktrup, J. C. Cappelleri, C. Beck, A. G. Bushmakin, M. Berry, J. Jackson
Summary: Across five European countries, the use of non-pharmacological and pharmacological treatments increases with greater osteoarthritis (OA) disease severity. Patients with more severe disease place a greater demand on healthcare resources, with consultations, tests, and hospital visits increasing with severity.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
John B. Arnold, Jill Halstead, Carmen Martin-Hervas, Andrew J. Grainger, Anne-Maree Keenan, Catherine L. Hill, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond
Summary: This study compared MRI-detected structural abnormalities in patients with symptomatic midfoot osteoarthritis, patients with persistent midfoot pain, and asymptomatic controls. The findings suggest a prevalence of osteoarthritis in individuals with persistent midfoot pain but no signs of OA on radiography, particularly in specific joints. However, the MRI abnormalities were not strongly associated with pain or foot-related disability.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
David Demanse, Franziska Saxer, Patrick Lustenberger, Philipp Nikolaus, Ilja Rasin, Damian F. Brennan, Ronenn Roubenoff, Sumehra Premji, Philip G. Conaghan, Matthias Schieker
Summary: This study used two different machine learning algorithms to identify distinct patient clusters in osteoarthritis population, in order to enable the development of effective therapies. Both deep embedded clustering and multiple factor analysis with clustering approaches identified comorbid patients with higher BMI and low physical activity, as well as young/physically active and elderly/physically inactive clusters. These findings could be helpful for early trial design to enrich for patients who may specifically benefit from disease-modifying treatments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Medicine, Research & Experimental
Lara S. Chapman, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Toby O. Smith, John B. Arnold, Dorcas Beaton, Philip G. Conaghan, Yvonne M. Golightly, Marian T. Hannan, Catherine Hofstetter, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Peter Tugwell, Philip Helliwell, Heidi J. Siddle
Summary: This study aims to develop a core outcome set (COS) for interventions in foot and ankle disorders in RMDs. Through literature reviews, qualitative interviews, and focus groups, important outcome domains will be identified and prioritized using an online consensus study and subsequent meeting. The findings will be disseminated widely to enhance uptake.
Article
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, Philip G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Marjan A. Versnel, Edward M. Vital
Summary: This study developed evidence-based points to consider for the measurement and reporting of IFN-I assays in clinical research. The study provides recommendations on terminology, assay characteristics, and reporting practices, as well as explores the clinical applications of IFN-I assays in diagnosis and outcome assessments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Gurjit S. Kaeley, Georg Schett, Philip G. Conaghan, Dennis McGonagle, Frank Behrens, Philippe Goupille, Corine Gaillez, Bhumik Parikh, Catherine Bakewell
Summary: This study evaluated the treatment response of enthesitis in PsA patients treated with secukinumab or adalimumab for 52 weeks. The results showed that both drugs had similar efficacy in resolving enthesitis, including time to resolution. The authors concluded that inhibition of IL-17 with secukinumab reduced clinical enthesitis similarly to TNF-alpha inhibition with adalimumab.
Editorial Material
Medicine, General & Internal
Helen Saul, Samantha Cassidy, Brendan Deeney, Jemma Kwint, Philip Conaghan
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Tarimobo M. Otobo, Mirkamal Tolend, Arthur B. Meyers, Iwona Sudol-Szopinska, Sayali Joshi, Jennifer Stimec, Nele Herregods, Jacob L. Jaremko, Shirley M. L. Tse, Nigil Haroon, Rahim Moineddin, Nikolay Tzaribachev, Simone Appenzeller, Michal Znajdek, Manuela Perez, Aloysius E. Ligha, Lennart Jans, Emilio Inarejos J. Clemente, Pamela Weiss, Olympia Papakonstantinou, Eva Kirkhus, Marion A. J. van Rossum, Dax G. Rumsey, John Carrino, Jonathan D. Akikusa, Philip G. Conaghan, Andrea S. Doria
Summary: This study used an adaptive multicriteria decision analysis to determine the relative weights of items in the JAMRIS-SIJ scoring system for juvenile idiopathic arthritis. Experts completed a conjoint analysis survey, comparing hypothetical patient profiles to determine the point value of the measurement items. The study found differences in relative weights among the JAMRIS-SIJ measurement items and validated the weighted scoring system.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
S. R. Kingsbury, L. K. K. Smith, R. Pinedo-Villanueva, A. Judge, R. West, J. M. Wright, M. H. Stone, P. G. Conaghan
Summary: This study conducted a systematic review and analysis of large datasets to provide recommendations for follow-up after total hip and knee arthroplasty. The recommendations suggest regular follow-up from 1 to 10 years post-surgery, with clinical and radiological evaluation at 10 years.
Article
Rheumatology
Gui Tran, Elizabeth M. A. Hensor, Sarah R. Kingsbury, Philip O'Connor, Paul Cowling, Philip G. Conaghan
Summary: This study aimed to determine if groups of ultrasound-based shoulder pathologies exist and how they relate to treatment outcomes. The results showed that current ultrasound-based classification methods cannot predict medium-term treatment outcomes for shoulder pain. Therefore, the role of routine diagnostic ultrasound for shoulder pain needs to be considered, and evidence-based therapies for specific pathologies should be established.
Article
Rheumatology
Lara S. Chapman, Jennifer Jones, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Catherine Hofstetter, Toby O. Smith, John B. Arnold, Marian T. Hannan, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Yvonne M. Golightly, Peter Tugwell, Dorcas Beaton, Philip G. Conaghan, Philip S. Helliwell, Heidi J. Siddle
Summary: The OMERACT Foot and Ankle Working Group is developing a core outcome set for foot and ankle disorders in rheumatic and musculoskeletal diseases, however, there is a lack of high-quality evidence on the effectiveness of treatments for these disorders. A scoping review was conducted to identify outcome domains in the existing literature and feedback was obtained on the next steps of the project. The findings from the review and the feedback will contribute to the development of the core outcome set.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Orthopedics
Bahram Mohajer, Kamyar Moradi, Ali Guermazi, Mahsa Dolatshahi, Frank W. Roemer, Hamza A. Ibad, Ghazaal Parastooei, Philip G. Conaghan, Bashir A. Zikria, Mei Wan, Xu Cao, Joao A. C. Lima, Shadpour Demehri
Summary: Statin use is associated with a slight decrease in MRI-based measures of thigh muscle quality over 4 years. However, considering statins' substantial cardiovascular benefits, these slight muscle changes may be relatively less important in overall patient care.
SKELETAL RADIOLOGY
(2023)