Article
Chemistry, Medicinal
Jakub Mlost, Marta Kedziora, Katarzyna Starowicz
Summary: The study focuses on the potential therapeutic effects of CBD on osteoarthritis by identifying molecular targets, notably the key role of PPAR gamma. It also highlights the potential heat hyperalgesia induced by CBD and the importance of bioinformatic tools in predicting its mechanism of action in different conditions. The findings pave the way for novel CBD-based therapies and encourage further research in this area.
Article
Multidisciplinary Sciences
Pushpanathan Muthuirulan, Dewei Zhao, Mariel Young, Daniel Richard, Zun Liu, Alireza Emami, Gabriela Portilla, Shayan Hosseinzadeh, Jiaxue Cao, David Maridas, Mary Sedlak, Danilo Menghini, Liangliang Cheng, Lu Li, Xinjia Ding, Yan Ding, Vicki Rosen, Ata M. Kiapour, Terence D. Capellini
Summary: Non-coding sequences may hold disease-specificity, with loci such as GDF5 showing multiple associations in joint disorders. By identifying causal variants for hip dysplasia and knee osteoarthritis, researchers pinpointed variants residing in site-specific enhancers. The study also found modularity patterns at GDF5 and other loci with multiple GWAS disease associations, suggesting common regulatory mechanisms for joint-specific diseases.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Yves Henrotin, Christophe Antoine, Elodie Zwerts, Thibaut Neutelings, Elodie Bouvret
Summary: The study aimed to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rats with surgically induced osteoarthritis. FCH did not significantly affect cartilage lesion severity but tended to accelerate pain relief and joint function recovery. This positive trend may lead to further research on FCH as a potential treatment for joint discomfort associated with osteoarthritis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Haruhisa Watanabe, Takashi Iori, Ji-Won Lee, Takashi S. S. Kajii, Aya Takakura, Ryoko Takao-Kawabata, Yoshimasa Kitagawa, Yutaka Maruoka, Tadahiro Iimura
Summary: Degenerative joint disease of the temporomandibular joints (DJD-TMJ) is characterized by orofacial pain, joint sounds, and limited jaw movements. This study investigated the potential of serum CCL5 level as a biomarker for DJD-TMJ and analyzed changes in bone metabolism rate as a predisposing factor. The results showed that DJD-TMJ subjects had significantly higher levels of serum CCL5 compared to the control subjects, especially in young individuals. This suggests that serum CCL5 level may serve as a biomarker for DJD-TMJ, and changes in bone metabolism rate may predispose individuals to this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Diana Amorim, Diana Fonseca-Rodrigues, Ana David-Pereira, Octavia Costa, Antonia Palhares Lima, Rosete Nogueira, Rute Cruz, Ana Sofia Martins, Liliana Sousa, Francisco Oliveira, Helder Pereira, Rogerio Pirraco, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
Summary: The injection of kaolin/carrageenan in the rat knee joint successfully models the physical and psychiatric features of human osteoarthritis. This experimental osteoarthritis allows for the study of disease mechanisms and evaluation of therapeutic strategies to halt disease progression at different stages.
Review
Pharmacology & Pharmacy
Vipin Arora, James N. Campbell, Man-Kyo Chung
Summary: Capsaicin, the pungent ingredient in chili peppers, can cause intense burning pain in humans, but it has also been used as an analgesic for chronic pain conditions. The analgesic effects of capsaicin depend on concentration, with low concentrations inducing short-term defunctionalization and high concentrations leading to long-term defunctionalization.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Orthopedics
P. Corrigan, T. Neogi, L. Frey-Law, S. R. Jafarzadeh, N. Segal, M. C. Nevitt, C. E. Lewis, J. J. Stefanik
Summary: This study aimed to investigate the relationship between pain sensitization and poor physical functioning in individuals with knee osteoarthritis (OA). The results showed that heightened pain sensitivity was associated with worse self-reported function and slower walking speed. However, its impact on performance-based function was minimal.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Colombe Otis, Emilie Bouet, Sokhna Keita-Alassane, Marilyn Frezier, Alienor Delsart, Martin Guillot, Agathe Bedard, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Bertrand Lussier, Francis Beaudry, Eric Troncy
Summary: Validating animal pain models is crucial for enhancing translational research and pharmacological treatment response. This study found that a calibrated slight exercise protocol combined with multimodal analgesia had positive effects on the MI-RAT model, particularly when used in conjunction with positive analgesics, reducing sensitivity to pain and improving joint structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Orthopedics
Peter E. Mueller, Thomas R. Niethammer
Summary: Bone marrow lesions (BML) are often caused by stress-related bone marrow edema, associated with cartilage loss. Treatment of cartilage damage requires addressing the underlying bone marrow edema, and the critical point for successful treatment of larger defects is treating the cartilage defect effectively.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Neurosciences
Laura Minnema, Ankita Gupta, Santosh K. Mishra, B. Duncan X. Lascelles
Summary: This study investigates the functional role of artemin/GFR alpha 3 signaling in osteoarthritis pain and finds that anti-artemin monoclonal antibody can reverse hypersensitivity and restore limb use.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Orthopedics
M. Loef, L. van de Stadt, S. Bohringer, A. -c. Bay-Jensen, A. Mobasheri, J. Larkin, F. P. J. G. Lafeber, F. J. Blanco, I. K. Haugen, F. Berenbaum, M. Giera, A. Ioan-Facsinay, M. Kloppenburg
Summary: This study investigated the association between lipidomic profile and osteoarthritis (OA) severity. The results showed that lipidomics explained only a minor portion of the variation in OA severity, with a stronger association observed in hand pain. The findings suggest the involvement of eicosanoids in OA severity.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Jacek A. Kopec, Allison J. Heath, Eric C. Sayre, Jolanda Cibere, Linda C. Li, Carlo A. Marra, Ran R. Liu, John M. Esdaile
Summary: The prevalence of self-reported physician-diagnosed osteoarthritis (OA) in adults in British Columbia, Canada is 18.4%, with over 40% of patients having OA in multiple sites. Females are more likely to report symptoms and OA than males in all joints.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Chun-De Liao, Yu-Yun Huang, Hung-Chou Chen, Tsan-Hon Liou, Che-Li Lin, Shih-Wei Huang
Summary: This network meta-analysis suggests that medium-energy ESWT combined with physical therapy or Chinese medicine is effective in treating pain and improving function in patients with knee osteoarthritis.
Review
Plant Sciences
Ji Hee Jun, Tae-Young Choi, Nicola Robinson, Ji-Yeun Park, Eun-Young Jun, Kyeong Han Kim, Hye Won Lee, Myeong Soo Lee, Sunju Park
Summary: This study systematically evaluated the clinical efficacy and safety of warm needle acupuncture (WA) in the treatment of osteoarthritis (OA) through a systematic review and meta-analysis. The results showed that WA may have advantages in improving the symptoms of OA and can achieve better treatment outcomes compared to oral drugs or intra-articular injections. However, studies on this therapy still have issues of bias risk and low certainty of evidence, and further well-designed randomized controlled trials are needed for validation.
Article
Multidisciplinary Sciences
Elin Sward, Maria Wilcke
Summary: This study retrospectively analyzed the effect of intra-articular PRP injection on patients with painful osteoarthritis in the thumb basal joint or STT joint. The results showed that PRP injections had no effect on pain, functional evaluation, grip strength, or key pinch. Further placebo-controlled studies are needed to investigate the efficacy of PRP in osteoarthritis of the thumb basal joint and STT joint.
Review
Rheumatology
Daniel F. McWilliams, Divya Thankaraj, Julie Jones-Diette, Rheinallt Morgan, Onosi S. Ifesemen, Nicholas G. Shenker, David A. Walsh
Summary: Oral glucocorticosteroids have analgesic effects on pain in patients with rheumatoid arthritis, but the effectiveness diminishes over time.
Article
Immunology
James Turnbull, Rakesh R. Jha, Catherine A. Ortori, Eleanor Lunt, Patrick J. Tighe, William L. Irving, Sameer A. Gohir, Dong-Hyun Kim, Ana M. Valdes, Alexander W. Tarr, David A. Barrett, Victoria Chapman
Summary: This study quantified the levels of pro- and anti-inflammatory bioactive lipids in the serum of SARS-CoV-2 patients and explored their potential relationships with innate responses and clinical outcomes. The results showed that SARS-CoV-2 infection was associated with increased levels of proinflammatory lipids and specialized proresolution molecules (SPMs), as well as correlations between SPMs, proinflammatory lipids, and anti-spike antibody binding. Some lipid mediators were significantly lower in SARS-CoV-2 patients who died.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Orthopedics
S. Koushesh, S. M. Shahtaheri, D. F. McWilliams, D. A. Walsh, M. N. Sheppard, J. Westaby, S. M. Haybatollahi, F. A. Howe, N. Sofat
Summary: By developing the Osteoarthritis Bone Score (OABS), researchers are able to identify and quantify the histopathological changes associated with bone marrow lesions (BMLs) in osteoarthritis (OA). The histopathology underlying BMLs may represent two inter-related pathological processes affecting trabecular and non-trabecular structures. Increased vascularity and perivascular innervation may contribute to the pain associated with BMLs.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
K. Aso, D. A. Walsh, H. Wada, M. Izumi, H. Tomitori, K. Fujii, M. Ikeuchi
Summary: This study investigated the time course of nerve growth factor (NGF) expression and sensory nerve growth during the progression of osteoarthritis (OA) in rat knees. The results showed that NGF expression increased in early stages and remained elevated in advanced stages, while sensory nerve innervation exhibited tissue-specific changes throughout the OA progression. These findings suggest that NGF plays a key role in articular nerve growth associated with OA pain.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
James M. Gwinnutt, Sam Norton, Kimme L. Hyrich, Mark Lunt, Bernard Combe, Nathalie Rincheval, Adeline Ruyssen-Witrand, Bruno Fautrel, Daniel F. McWilliams, David A. Walsh, Elena Nikiphorou, Patrick D. W. Kiely, Adam Young, Jacqueline R. Chipping, Alex MacGregor, Suzanne M. M. Verstappen
Summary: This study investigated the impact of social support, financial status, and lifestyle on the development of excess disability in rheumatoid arthritis (RA). The study found that individuals with less social support, worse financial situation, less exercise, and lower education were more likely to have excess disability. These findings were validated in two independent datasets.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Orthopedics
D. A. Walsh, N. Sofat, A. Guermazi, D. J. Hunter
Summary: Assessment and treatment of Bone Marrow Lesions (BMLs) have the potential to significantly improve the lives of people with osteoarthritis (OA). This review examines the characteristics of OA-BMLs, their diagnosis and measurement, and their associations with pain and OA structural progression. The article discusses the factors contributing to BML pathogenesis and the potential of interventions targeting BMLs to reduce pain and slow down OA progression. The evaluation methods for BMLs and their usefulness in identifying individuals at risk and evaluating treatment responses are critically appraised.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Orthopedics
V. Georgopoulos, S. Smith, D. F. McWilliams, M. P. M. Steultjens, A. Williams, A. Price, A. M. Valdes, T. L. Vincent, F. E. Watt, D. A. Walsh
Summary: This study aimed to harmonize patient-reported outcome measures (PROMs) in knee pain due to osteoarthritis or knee trauma using the Patient Acceptable Symptom State scores (PASS) as a criterion. Standardized PROMs showed similar PASS thresholds in group data, but divergent scores within individuals.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Editorial Material
Rheumatology
Daniel F. McWilliams, David A. Walsh
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Geriatrics & Gerontology
Wendy J. Chaplin, Daniel F. McWilliams, Bonnie S. Millar, John R. F. Gladman, David A. Walsh
Summary: A bidirectional relationship exists between joint pain and frailty, with each potentially accelerating the progression of the other. Therefore, addressing pain is crucial in preventing frailty, and including pain measures as an outcome in frailty studies is justified.
Article
Health Care Sciences & Services
Daniel F. Mcwilliams, Bin Yue, Stephanie L. Smith, Joanne Stocks, Michael Doherty, Ana M. Valdes, Weiya Zhang, Aliya Sarmanova, Gwen S. Fernandes, Kehinde Akin-Akinyosoye, Michelle Hall, David A. Walsh
Summary: Knee pain is associated with lower muscle strength, and both peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help future treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Analytical
Malak A. Jaber, Bruna de Falco, Salah Abdelrazig, Catharine A. Ortori, David A. Barrett, Dong-Hyun Kim
Summary: In comprehensive lipidomics studies, accurate quantification is hindered by unwanted variations such as lipid degradation, matrix effects, and non-linear responses of instruments. This study employed an in vivo labelling strategy to generate C-13-labelled internal standards (C-13-ISs) from different species for more accurate and quantitative lipidomics analysis. The use of C-13-labelled P. pastoris extract as internal standards resulted in significant reduction in lipid variations compared to other normalization methods. This study highlights the benefit of in vivo labelling strategy in reducing technical and analytical variations in lipidomics studies.
ANALYTICAL METHODS
(2023)
