Article
Rheumatology
William Murray-Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon, Malcolm D. Smith, Susan E. Lester, Susanna M. Proudman, Navin L. Rao, Ling-Yang Hao, Sunil Nagpal, Mihir D. Wechalekar
Summary: This study aimed to characterize PD-1-expressing Tph cells in early rheumatoid arthritis and found that these cells accumulate prior to fully established disease.
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Chemistry, Multidisciplinary
David A. A. McBride, Matthew D. D. Kerr, Wade T. T. Johnson, Anders Nguyen, Martina Zoccheddu, Mina Yao, Edward B. B. Prideaux, Nicholas C. C. Dorn, Wei Wang, Mattias N. D. Svensson, Nunzio Bottini, Nisarg J. J. Shah
Summary: An immunoregulatory approach based on sustained release of all-trans retinoic acid (ATRA) has been developed to modulate local immune activation and enhance disease-protective T cells for the treatment of autoimmune inflammatory arthritides. The ATRA is encapsulated in biodegradable microparticles and injected into the arthritic mouse joints, leading to the migration of T cells and reduction of inflammation. This approach shows potential as a disease modifying agent for autoimmune arthritis.
Article
Immunology
Gemma Vidal-Pedrola, Najib Naamane, James A. Cameron, Arthur G. Pratt, Andrew L. Mellor, John D. Isaacs, Dagmar Scheel-Toellner, Amy E. Anderson
Summary: Age-associated B cells (ABCs) are an immune cell subset linked to autoimmunity, infection, and aging. Studies have shown that ABCs in the peripheral blood of patients with early rheumatoid arthritis (eRA) exhibit distinct transcriptional characteristics compared to control groups, and they are found to be abundant in synovial fluid. These activated B cells express chemokine receptors and adhesion molecules that favor inflammation over lymphoid tissue, and they may play a role in autoimmune pathology due to their antigen presentation and pro-inflammatory phenotype.
Article
Immunology
Anuja Singh, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Tanveer Naved, Saurabh Bhatia, Ahmed Al-Harrasi, Prasun Chakrabarti, Lotfi Aleya, Celia Vargas-De-La-Cruz, Simona Bungau
Summary: Rheumatoid arthritis is an autoimmune disease characterized by severe inflammation that damages tendons, cartilage, and bones. B cells play a significant role in the pathogenesis of RA, and targeting B cells has shown therapeutic efficacy in treating autoantibody-related conditions, including RA. The development of B-cell-targeted therapies has led to a better understanding of the diverse roles of B cells in autoimmune diseases and their potential as effective treatment targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Constantina A. Bounia, Stamatis-Nick C. Liossis
Summary: Treatment with rituximab (RTX) significantly reduces circulating Th17 cell percentages in patients with RA, while Tregs remain stable. Reduction of Th17 cells is particularly evident in responders to RTX treatment, ACPA+ and RF (-) patients with RA.
CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Tsuyoshi Nakayama, Motoki Yoshimura, Kazuhiko Higashioka, Kohta Miyawaki, Yuri Ota, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The efficacy of B-cell depletion therapy in rheumatoid arthritis highlights the antibody-independent effector functions of B cells. Studies have shown that Th1 cells can promote the generation of CXCL9/10-producing T-bet+ B cells in RA, suggesting a potential novel target for therapy.
CELLULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hahnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Summary: In early RA patients and individuals at risk for RA, there is an increase in Tfh cells in lymphoid tissues with decreased IL-21 production.
Article
Medicine, General & Internal
Suiyuan Hu, Yuting Tao, Fanlei Hu, Xu Liu
Summary: This study found that LAG3(+) B cells were significantly decreased in rheumatoid arthritis (RA) patients and negatively correlated with disease activity. The same trend was observed in mice. Reconstitution of LAG3(+) B cells might offer new therapeutic strategies for RA.
ANNALS OF MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Fengping Wu, Jinfang Gao, Jie Kang, Xuexue Wang, Qing Niu, Jiaxi Liu, Liyun Zhang
Summary: Rheumatoid arthritis is a common, chronic, systemic autoimmune disease characterized by immune system disorders, with autoreactive CD4(+)T cells, pathogenic B cells, and inflammatory cytokines being key players. Further research is needed to distinguish between pathogenic B cells and protective B cells in patients with RA to develop more targeted treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Yi Qin, Ming-Long Cai, Hui-Zhi Jin, Wei Huang, Chen Zhu, Aline Bozec, Jingang Huang, Zhu Chen
Summary: This study found that ABCs contribute to the pathogenesis of RA by inducing the activation of FLS via TNF-alpha-mediated signaling pathways.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Tamara H. Ramwadhdoebe, Lisa G. M. van Baarsen, Maria J. H. Boumans, Stefan T. G. Bruijnen, Mary Safy, Ferco H. Berger, Johanna F. Semmelink, Conny J. van der Laken, Danielle M. Gerlag, Rogier M. Thurlings, Paul P. Tak
Article
Multidisciplinary Sciences
Esperanza Perucha, Rossella Melchiotti, Jack A. Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Maartje J. Levels, Cynthia M. Fehres, Lisa G. M. van Baarsen, Nathalie O. P. van Uden, Kristine Germar, Tom G. O'Toole, Iris C. J. Blijdorp, Johanna F. Semmelink, Marieke E. Doorenspleet, Arjen Q. Bakker, Mikhail Krasavin, Alexey Tomilin, Sophie Brouard, Hergen Spits, Dominique L. P. Baeten, Nataliya G. Yeremenko
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Cell Biology
T. H. Ramwadhdoebe, M. Ramos, K. Maijer, K. P. van Lienden, M. Maas, D. M. Gerlag, P. P. Tak, M. C. Lebre, L. G. M. van Baarsen
Article
Biochemistry & Molecular Biology
Janine S. Hahnlein, Reza Nadafi, Tineke A. de Jong, Johanna F. Semmelink, Ester B. M. Remmerswaal, Mary Safy, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Reina E. Mebius, Heidi Wahamaa, Anca Catrina, Lisa G. M. van Baarsen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Immunology
Catarina Gago da Graca, Lisa G. M. van Baarsen, Reina E. Mebius
Summary: This review focuses on the role of lymph node stromal cells and TLSs in coordinating adaptive immune responses and their potential impact on diseases, particularly autoimmunity and cancer. The discussion includes recent findings on the function and formation of these structures and their possible role in promoting tolerance.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
C. Grasso, C. Pierie, R. E. Mebius, L. G. M. van Baarsen
Summary: Lymph nodes stromal cells are crucial for guiding adaptive immune responses, with recent advancements in single-cell technologies revealing significant heterogeneity among subsets. While most knowledge comes from mouse studies, some similarities with human counterparts suggest their importance.
TRENDS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Janne W. Bolt, Arno W. van Kuijk, Marcel B. M. Teunissen, Dennis van der Coelen, Saida Aarrass, Danielle M. Gerlag, Paul P. Tak, Marleen G. van de Sande, Maria C. Lebre, Lisa G. M. van Baarsen
Summary: IL-17 and TNF-α play crucial roles in the pathogenesis of psoriatic arthritis (PsA), but blocking TNF does not affect the levels of IL-17 at inflammation sites, which may provide rationale for the combination inhibition of both cytokines.
Article
Immunology
Tineke A. de Jong, Maria J. H. de Hair, Marleen G. H. van de Sande, Johanna F. Semmelink, Ivy Y. Choi, Danielle M. Gerlag, Paul P. Tak, Lisa G. M. van Baarsen
Summary: This study aimed to identify molecular changes in synovium before the development of rheumatoid arthritis (RA) in individuals at risk. The results revealed that alterations in adaptive immune response and lipid metabolism in synovium are associated with future development of arthritis.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Cell Biology
Tineke A. de Jong, Johanna F. Semmelink, Simone W. Denis, Janne W. Bolt, Mario Maas, Marleen G. H. van de Sande, Riekelt H. L. Houtkooper, Lisa G. M. van Baarsen
Summary: Cellular metabolism plays a crucial role in determining cell function and immune responses. Stromal cells in the lymph node microenvironment have been found to be important in regulating immune tolerance. Dysfunction of these cells may contribute to the development of autoimmune diseases such as rheumatoid arthritis (RA). In this study, we investigated the metabolic profile of these cells in individuals at risk of developing RA, RA patients, and healthy volunteers.
Article
Rheumatology
Janne W. Bolt, Caroline J. Aalbers, Laura Walet, Leonieke J. J. van Mens, Christiaan van Denderen, Irene van der Horst-Bruinsma, Lisa G. M. van Baarsen, Robert Landewe, Marleen G. H. van de Sande
Summary: The clear target for treating axial spondyloarthritis (axSpA) has not been defined yet, and the targets may not always reflect inflammation. This study found discrepancies between physicians' and patients' opinions and composite indices regarding residual disease activity, which influenced treatment decisions.
Meeting Abstract
Rheumatology
T. A. De Jong, A. L. Timmerman, J. F. Semmelink, J. S. Hahnlein, L. G. van Baarsen
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
C. Grasso, J. S. Hahnlein, R. Nadafi, T. A. De Jong, T. H. Ramwadhdoebe, J. F. Semmelink, D. M. Gerlag, P. P. Tak, R. E. Mebius, M. Safy, M. Maas, A. I. Catrina, H. Wahamaa, L. G. M. Van Baarsen
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
L. G. Van Baarsen, M. J. de Hair, J. F. Semmelink, I. Y. Choi, D. M. Gerlag, P. P. Tak
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Janine S. Hahnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius, Lisa G. M. van Baarsen
ARTHRITIS RESEARCH & THERAPY
(2018)