Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Immunology
Luna Ge, Ting Wang, Dandan Shi, Yun Geng, Huancai Fan, Ruojia Zhang, Yuang Zhang, Jianli Zhao, Shufeng Li, Yi Li, Haojun Shi, Guanhua Song, Jihong Pan, Lin Wang, Jinxiang Han
Summary: The study identifies the pathogenic role of ATF6 alpha-BIRC3 axis in rheumatoid arthritis and presents a novel pathway for new therapies against RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
E. R. Zacca, M. C. Amezcua Vesely, P. Ferrero, C. D. Acosta, N. E. Ponce, S. N. Bossio, E. Mussano, L. Onetti, I Cadile, E. Acosta Rodriguez, C. L. Montes, A. Gruppi
Summary: The study revealed that in untreated RA patients, B cell-mediated regulatory function through CD39 was maintained, while well-responding patients showed increased CD39 expression on B cells after treatment. The changes in CD39 expression were associated with disease activity and treatment response.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Article
Cell Biology
Alexandra H. Mandarano, Tarsha L. Harris, Blaine M. Creasy, Marie Wehenkel, Marygrace Duggar, Benjamin A. Wilander, Ashutosh Mishra, Jeremy Chase Crawford, Sarah A. Mullen, Katherine M. Williams, Meenu Pillai, Anthony A. High, Maureen A. McGargill
Summary: Drak2-deficient mice are resistant to autoimmune diseases and effectively eliminate pathogens and tumors. The absence of Drak2 in T cells leads to resistance to type 1 diabetes (T1D) in non-obese diabetic (NOD) mice, which requires the presence of regulatory T cells (Tregs). Drak2 regulates IL-2 signaling by inhibiting STAT5A phosphorylation, and its absence enhances thymic Treg development.
Article
Biochemistry & Molecular Biology
Noor Mustafa, Jone Mitxelena, Arantza Infante, Olatz Zenarruzabeitia, Ainhoa Eriz, Ainhoa Iglesias-Ara, Ana M. Zubiaga
Summary: Disruption of E2f2 in mice leads to T-cell hyperactivation and disproportionate cell cycle entry. However, E2f2(-/-) mice do not develop lymphoproliferative condition. We find that E2f2 plays an anti-apoptotic role through the Fas pathway in vitro and in vivo. Knockout of E2f2 in TCR-stimulated T cells results in overexpression of proapoptotic genes, enhanced apoptosis, and activated p53 pathway. However, E2f2-Fas/FasL signaling is p53-independent. E2f2 is recruited to Fas and FasL gene promoters to repress their expression. E2f2(-/-) mice are prone to immune-mediated liver injury due to aberrant lymphoid Fas/FasL activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Amanda J. Eakin, Tahanver Ahmed, Cathy M. McGeough, Stephen Drain, H. Denis Alexander, Gary D. Wright, Philip Gardiner, Dawn Small, Anthony J. Bjourson, David S. Gibson
Summary: This study investigates the relationship between disease activity in rheumatoid arthritis (RA) and the numbers and phenotypes of circulating regulatory T cells (Tregs) and monocytes. It also explores the potential sialic acid link between Tregs and monocytes and the effects of sialic acid on Treg activation and cytokine release.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rikio Yabe, Soo-Hyun Chung, Masanori A. Murayama, Sachiko Kubo, Kenji Shimizu, Yukiko Akahori, Takumi Maruhashi, Akimasa Seno, Tomonori Kaifu, Shinobu Saijo, Yoichiro Iwakura
Summary: TARM1, a member of the LILR family, plays a crucial role in activating dendritic cells in inflammatory arthritis. The interaction between TARM1 and collagens promotes the maturation of dendritic cells and facilitates the progression of CIA, while soluble TARM1-Fc fusion protein shows potential in limiting CIA in mice.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra
Summary: In patients with rheumatoid arthritis, regulatory T cells in the synovial fluid are impaired in their function. Blocking the action of IL-9 can restore the function of regulatory T cells and reduce the production of inflammatory T cells.
CLINICAL IMMUNOLOGY
(2023)
Review
Cell Biology
Siyu Wang, Hua Wang, Chengyao Feng, Chenbei Li, Zhihong Li, Jieyu He, Chao Tu
Summary: Pyroptosis is a controlled form of inflammatory cell death that has been increasingly studied in musculoskeletal diseases. It is triggered by oxidative stress and proinflammatory substances, leading to cell lysis, release of cytosolic components and proinflammatory cytokines, and amplification of the inflammatory response. This review summarizes the molecular mechanism of pyroptosis, discusses its differences and crosstalk with apoptosis and necrosis, and explores its role in various musculoskeletal diseases.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Anna Estrada Brull, Felix Rost, Josua Oderbolz, Florian R. Kirchner, Salome Leibundgut-Landmann, Annette Oxenius, Nicole Joller
Summary: This study investigates Treg specialization in persistent viral infections, specifically in chronic LCMV infection, and identifies the important functional role of CD85k in Treg-mediated suppression of type 1 immunity. These findings provide new insights into immune regulation in the context of chronic viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Brian M. Dulmovits, Yuefeng Tang, Julien Papoin, Mingzhu He, Jianhua Li, Huan Yang, Meghan E. Addorisio, Lauren Kennedy, Mushran Khan, Elena Brindley, Ryan J. Ashley, Cheryl Ackert-Bicknell, John Hale, Ryo Kurita, Yukio Nakamura, Betty Diamond, Betsy J. Barnes, Olivier Hermine, Patrick G. Gallagher, Laurie A. Steiner, Jeffrey M. Lipton, Naomi Taylor, Narla Mohandas, Ulf Andersson, Yousef Al-Abed, Kevin J. Tracey, Lionel Blanc
Summary: High mobility group box-1 protein (HMGB1) interferes with EPO signaling pathways, leading to reduced expansion and increased death of EPO-sensitive erythroid precursors in patients with anemia of inflammation. This study provides important insights into the chronic phase of anemia of inflammation.
Review
Cardiac & Cardiovascular Systems
Sameera Helal, Geraldine Lee, Catherine Evans, Annmarie Grealish
Summary: This study aimed to explore the efficacy of psychological interventions in reducing depression and improving quality of life and clinical outcomes among adults with chronic heart failure (CHF). The findings suggest that cognitive behavioral therapy is associated with improved depression, quality of life, and reduced hospitalization risk. Mindfulness-based psychoeducation, holistic meditation, and coping skills training also have a positive impact on depression and quality of life, with coping skills training further reducing hospitalization and mortality risks.
JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Rheumatology
Muhammad Ruhul Amin Shipa, Su-Ann Yeoh, Andrew Embleton-Thirsk, Dev Mukerjee, Michael R. Ehrenstein
Summary: This study investigated the impact of combined HCQ and MTX therapy on the clinical response of RA patients. The results showed that combined HCQ and MTX therapy doubled the likelihood of patients achieving clinical remission or low disease activity at 6 months. The improvement in clinical outcomes was associated with an accelerated increase in MCV from 2 months after starting therapy, and the increase in MCV was comparable to the decrease in DAS in predicting clinical response at 6 months.
Article
Obstetrics & Gynecology
P. Muller, I Gurol-Urganci, R. Thakar, M. R. Ehrenstein, J. van der Meulen, S. Jha
Summary: This study compared the incidence of systemic conditions between women undergoing stress incontinence surgery with and without mesh, finding similar rates of autoimmune disease, fibromyalgia, or myalgic encephalomyelitis within 10 years post-surgery. The results do not support the notion that synthetic mesh slings cause systemic diseases.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Muhammad Shipa, Andrew Embleton-Thirsk, Mariea Parvaz, Liliana Ribeiro Santos, Patrick Muller, Kashfia Chowdhury, David A. Isenberg, Caroline J. Dore, Caroline Gordon, Michael R. Ehrenstein
Summary: In patients with refractory systemic lupus erythematosus (SLE), the use of belimumab following rituximab significantly reduced serum IgG anti-dsDNA antibody levels and decreased the risk of severe disease flares, suggesting the potential for this combination as a therapeutic strategy.
ANNALS OF INTERNAL MEDICINE
(2021)
Editorial Material
Nursing
Catherine J. Evans, Anna E. Bone, Deokhee Yi, Myfanwy Morgan, Matthew Maddocks, Juliet Wright, Fiona Lindsay, Irene J. Higginson
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Multidisciplinary Sciences
Jonathan Koffman, Clarissa J. Penfold, Laura Cottrell, Bobbie Farsides, Catherine Evans, Rachel Burman, Richard Nicholas, Stephen Ashford, Eli Silber
Summary: This study explores the engagement of people with multiple sclerosis (MS) and their families in advance care planning (ACP). The findings suggest that their engagement is influenced by various factors, including uncertainty about the future, negative experiences, and prioritizing symptom management. Health professionals view ACP as an ongoing process of seeking preferences and values rather than a formal document. Both patients and health professionals express concerns about uncertainty and when to initiate ACP discussions.
Letter
Rheumatology
Muhammad R. A. Shipa, Lawrence Langley, Benjamin Sacks, Su-Ann Yeoh, M. D. Mainuddin, Dev Mukerjee, Madhura Castelino, Michael R. Ehrenstein
Article
Geriatrics & Gerontology
Javiera Leniz, Catherine J. Evans, Deokhee Yi, Anna E. Bone, Irene J. Higginson, Katherine E. Sleeman
Summary: This study aims to explore the costs of formal and informal care in the last 3 months of life for people with dementia and evaluate the association between transitions to hospital and usual place of care with costs.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Joanna Goodrich, Lydia Tutt, Alice M. Firth, Catherine J. Evans, Fliss Em Murtagh, Richard Harding
Summary: This Delphi study identified the most important components for providing out-of-hours community palliative care, including prescription, delivery and administration of medicines, district and community nurse visits, and shared electronic patient records and advance care plans.
PALLIATIVE MEDICINE
(2022)
Article
Geriatrics & Gerontology
Lesley E. Williamson, Javiera Leniz, Emeka Chukwusa, Catherine J. Evans, Katherine E. Sleeman
Summary: This study examined the individual- and service-level factors associated with emergency department (ED) visits by people with dementia in the last year of life in England. The findings showed that South Asian ethnicity, chronic respiratory disease, and urban residence were associated with more ED visits, while higher socioeconomic position and higher numbers of nursing home beds were associated with fewer ED visits.
Article
Medicine, General & Internal
Peter C. Taylor, Ayman Askari, Ernest Choy, Michael R. Ehrenstein, Sara Else, Muhammad K. Nisar
Summary: The recent guideline changes have approved the use of three biologics for the treatment of moderately active RA. However, challenges exist in educating physicians and patients, identifying suitable patients, and adapting to telemedicine consultations during the COVID-19 pandemic.
Editorial Material
Immunology
Michael R. Ehrenstein, Muhammad Shipa
Summary: This Viewpoint discusses the application of experimental medicine in clinical trials to address unmet need in systemic lupus erythematosus (SLE), a prototypic autoimmune disease, with the aim of improving patient outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Alice M. Firth, Cheng-Pei Lin, Deok Hee Yi, Joanna Goodrich, Inez Gaczkowska, Frances Waite, Richard Harding, Fliss E. M. Murtagh, Catherine J. Evans
Summary: This study systematically reviewed the components, outcomes, and economic evaluation of community-based 'out-of-hours' care for patients near the end of life and their families. The importance of being known to a service and high-quality coordination of care were identified as key themes. The study calls for further research on the impact and cost effectiveness of different models of out-of-hours care.
PALLIATIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Andy Bradshaw, Sophia Ostler, Claire Goodman, Izabele Batkovskyte, Clare Ellis-Smith, India Tunnard, Anna E. Bone, Stephen Barclay, Martin Vernon, Irene J. Higginson, Catherine J. Evans, Katherine E. Sleeman
Summary: This study investigated the impact of COVID-19 on the provision of palliative and end-of-life care in UK care homes. The results emphasize the importance of relationship-centered care and highlight the need for policy priorities such as integration, digital inclusivity, workforce development, and support for care home managers. These findings contribute to the broader discussions and initiatives on improving palliative care globally.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Clinical Neurology
Jesutofunmi Aworinde, Clare Ellis-Smith, Juliet Gillam, Moise Roche, Lucy Coombes, Emel Yorganci, Catherine J. Evans
Summary: This study conducted a mixed-methods systematic review to explore the use of person-centered outcome measures (PCOMs) in dementia care. The findings suggest that PCOMs can facilitate shared decision-making and improve outcomes by promoting collaboration between the person's network of family and practitioners. The constructed logic model identifies key mechanisms for discussing care priorities, evaluating decisions, and assessing outcomes.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)