Article
Immunology
Samer R. Khan, Virgil A. S. H. Dalm, M. Kamran Ikram, Robin P. Peeters, P. Martin van Hagen, Maryam Kavousi, Layal Chaker
Summary: This study examined the association between total serum immunoglobulin (Ig) A, G, and M and cardiovascular disease (CVD) across the spectrum of atherosclerosis in community-dwelling elderly. The results showed that higher IgG was associated with increased CVD risk, cardiovascular mortality risk, and all-cause mortality risk. Higher IgA was associated with severe atherosclerosis.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Orthopedics
J. S. Teunissen, R. M. Wouters, S. M. A. Bierma-Zeintra, J. B. J. van Meurs, T. A. R. Schreuders, J. M. Zuidam, R. W. Selles
Summary: This study aims to investigate the prevalence, incidence, and progression of radiographic thumb carpometacarpal (CMC-1) and trapezioscaphoid (TS) radiographic osteoarthritis (ROA) in the general Dutch population aged >= 55y. The results showed that CMC-1 ROA and TS ROA are prevalent in the general Dutch population, and female gender and increasing age are associated with an increased risk of these two conditions.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Clinical Neurology
Samer R. Khan, Amber Yaqub, M. Kamran Ikram, P. Martin van Hagen, Robin P. Peeters, Virgil A. S. H. Dalm, Layal Chaker, M. Arfan Ikram
Summary: This study found no significant association between serum immunoglobulins and dementia in a population-based cohort. However, higher IgG levels were associated with worse cognitive function, but further longitudinal studies are needed to exclude the possibility of reverse causation.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Tian Xiao, Samuel Ghatan, Sanne S. Mooldijk, Katerina Trajanoska, Ling Oei, M. Medina Gomez, M. Kamran Ikram, Fernando Rivadeneira, M. Arfan Ikram
Summary: Low bone mineral density (BMD) is associated with an increased risk of dementia in older adults. Individuals with lower BMD at the femoral neck and total body are more likely to develop dementia, and the risk is greatest within the first 10 years after baseline.
Article
Nutrition & Dietetics
Limin Wu, Haibo Si, Yi Zeng, Yuangang Wu, Mingyang Li, Yuan Liu, Bin Shen
Summary: Iron intake is associated with the progression of knee osteoarthritis in a U-shaped manner, with optimal intake range of 10.9-23.3 mg/day. Both excessive and deficient iron intake increase the risk of knee osteoarthritis progression.
Article
Cardiac & Cardiovascular Systems
Kosuke Inoue, Teresa E. Seeman, Tamara Horwich, Matthew J. Budoff, Karol E. Watson
Summary: Coronary artery calcium (CAC) is an important predictor of cardiovascular disease (CVD), but the impact of positive CAC on CVD varies among individuals. A study found that nearly 70% of low-risk individuals showed a significant increase in CVD risk when CAC>0, highlighting the need for CAC screening in these individuals.
Article
Clinical Neurology
Tian Xiao, Laurens van Kleef, M. Kamran Ikram, Robert De Knegt, M. Arfan Ikram
Summary: The study found no significant association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with an increased risk for incident dementia among the elderly. In fact, NAFLD was even protective in the first 5 years of follow-up before dementia onset.
Article
Public, Environmental & Occupational Health
Jurate Aleknaviciute, Tavia E. Evans, Elif Aribas, Merel W. de Vries, Eric A. P. Steegers, Mohammad Arfan Ikram, Henning Tiemeier, Maryam Kavousi, Meike W. Vernooij, Steven A. Kushner
Summary: The peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women's lives. Research has found that pregnancy and childbirth lead to long-term changes in brain structure, including a larger global gray matter volume.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Rheumatology
Thomas A. Perry, Xia Wang, Michael Nevitt, Christina Abdelshaheed, Nigel Arden, David J. Hunter
Summary: In participants with radiographic knee osteoarthritis, current use of NSAIDs was associated with a faster loss of medial minimum joint space width compared to non-users. No other significant associations were observed with the use of other medication classes and change in mJSW. Further clinical trials are needed to evaluate the potential disease-modifying effects of these medications.
Article
Rheumatology
Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z. Lim, Graeme Jones, Catherine L. Hill, Anita E. Wluka, Andrew Tonkin, Changhai Ding, Flavia M. Cicuttini
Summary: This study found evidence for the involvement of vascular pathology in the progression of knee osteoarthritis and suggested that targeting atherosclerosis could improve outcomes in knee osteoarthritis.
Article
Cardiac & Cardiovascular Systems
Amer G. Abdulla, Petra Buzkova, Rine Nakanishi, Matthew J. Budoff
Summary: The study found no association between anger, hostility, anxiety, or depression and coronary artery calcium (CAC), suggesting that these personality traits are not independent risk factors for cardiovascular disease.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2021)
Article
Plant Sciences
Kai Sun, Jiahui Luo, Xingzhi Jing, Wei Xiang, Jiachao Guo, Xudong Yao, Shuang Liang, Fengjing Guo, Tao Xu
Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.
Letter
Clinical Neurology
Vinod K. Gupta
Summary: Xiao et al. found that NAFLD is associated with a reduced risk of dementia and cognitive decline in the first 5 years of the disease, potentially due to weight loss prior to dementia onset. The biology of any illness involves the coordinated activation of multiple physiological processes, leading to cause-effect-adaptive continuum that either promotes or hinders the development of diseases, including dementia.
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: Dr. Xiao et al. found no association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with incident dementia and cognition. Interestingly, there was a lower risk of incident dementia in the first 5 years after NAFLD diagnosis. The authors suggest that this may simply reflect the absence of weight loss rather than any true protective effect against dementia.
Letter
Clinical Neurology
Laurens A. van Kleef, Tian Xiao, Robert J. de Knegt, M. Arfan Ikram
Summary: In our recent study, we found no evidence to suggest that fatty liver disease increases the risk of dementia or impairs cognitive function, regardless of the duration of follow-up. We appreciate Dr. Gupta's interest in our findings.
Article
Education & Educational Research
Josepha Kuhn, Silvia Mamede, Pieter van den Berg, Laura Zwaan, Petra van Peet, Patrick Bindels, Tamara van Gog
Summary: This study investigated whether general practice residents would learn the deliberate reflection procedure through 'learning-by-teaching' and apply it to diagnose new cases. The results showed no significant differences between the conditions in the test phase, indicating that teaching deliberate reflection to a fictitious peer did not increase the residents' reflective reasoning when diagnosing future cases.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Review
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Sven Geurts, Angelo M. Pezzullo, Wichor M. Bramer, Natasja M. S. de Groot, Maryam Kavousi, Moniek P. M. de Maat
Summary: This study aims to summarize and analyze the evidence on the associations between coagulation factors and atrial fibrillation (AF) in both longitudinal and cross-sectional studies. The findings suggest that higher levels of coagulation factors are associated with both prevalent and incident AF, with the associations being more pronounced in cross-sectional studies. Limited evidence from longitudinal studies suggests a prothrombotic state underlying AF development.
Article
Education & Educational Research
Charlotte G. M. van Sassen, Pieter J. van den Berg, Silvia Mamede, Lilian Knol, Manon P. Eikens-Jansen, Walter W. van den Broek, Patrick J. E. Bindels, Laura Zwaan
Summary: The study aimed to identify and prioritize educational content from a malpractice claims database to enhance clinical reasoning education in General Practitioners' training. The prioritized conditions included complex common, complex rare, and more straightforward common conditions, often exhibiting atypical presentations or complex contextual factors.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Rheumatology
S. E. (Sabine) Kloprogge, N. (Nienke) Katier, A. K. E. (Adinda) Mailuhu, J. (Jeanette) van Vooren, J. M. (John) van Ochten, P. J. E. (Patrick) Bindels, S. M. A. (Sita) Bierma-Zeinstra, M. (Marienke) van Middelkoop
Summary: This study aimed to determine the prevalence of radiographic ankle osteoarthritis (OA) in a population referred for ankle radiography, and to identify differences in prevalence between specific subgroups of patients. The results showed that the prevalence of radiographic ankle OA was 9.2%, 0.4%, and 7.0% for the talocrural, subtalar, and talonavicular joints, respectively. Obesity and male sex were associated with higher prevalence of ankle OA.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Juliana Alexandra Hernandez Vargas, Silvia Juliana Trujillo-Caceres, Julieth Pilar Uriza-Pinzon, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fang Zhu, Yannick Kaiser, Eric Boersma, Daniel Bos, Maryam Kavousi
Summary: This research investigated the association between aortic valve calcium (AVC) and subclinical cardiac dysfunction as well as the risk of heart failure (HF). Computed tomography-assessed AVC was found to be associated with echocardiographic measurements of cardiac dysfunction and the development of HF in the general population.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Nutrition & Dietetics
Carolina Ochoa-Rosales, Niels van der Schaft, Kim V. E. Braun, Frederick K. Ho, Fanny Petermann-Rocha, Fariba Ahmadizar, Maryam Kavousi, Jill P. Pell, M. Arfan Ikram, Carlos A. Celis-Morales, Trudy Voortman
Summary: This study explored the association between coffee consumption and the risk of type 2 diabetes. It found that increasing coffee intake by one cup per day was associated with a 4% decrease in the risk of developing diabetes. Furthermore, coffee intake was also associated with reduced insulin resistance, lower levels of the inflammatory marker CRP, and elevated adiponectin and IL-13 concentrations. CRP partially mediated the inverse association between coffee intake and diabetes incidence.
CLINICAL NUTRITION
(2023)
Letter
Cardiac & Cardiovascular Systems
Martijn J. Tilly, Natasja M. S. de Groot, Maryam Kavousi
Article
Endocrinology & Metabolism
Kan Wang, Fariba Ahmadizar, Sven Geurts, Banafsheh Arshi, Jan A. Kors, Dimitris Rizopoulos, Eric J. G. Sijbrands, M. Arfan Ikram, Maryam Kavousi
Summary: This study examined the association between the longitudinal evolution of heart rate variability (HRV) and the development of type 2 diabetes (T2D). The results showed that an increase in heart rate and a decrease in HRV were independently associated with the incidence of T2D, especially among younger individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Sven Geurts, Martijn J. Tilly, Jan A. Kors, Jaap W. Deckers, Bruno H. C. Stricker, Natasja M. S. de Groot, M. Arfan Ikram, Maryam Kavousi
Summary: The study aims to assess the association and sex differences in electrocardiographic parameters with new-onset atrial fibrillation (AF). A total of 12,212 participants from the Rotterdam Study were included. The findings showed that the associations between electrocardiographic parameters and new-onset AF were mostly U- and N-shaped, with significant sex differences observed. Longitudinal measures of PR and QTc interval were significantly associated with new-onset AF, especially in men.
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with atherosclerotic cardiovascular disease (ASCVD) being the main contributor. ASCVD mortality is currently increasing, especially in middle-aged women. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause, and polycystic ovary syndrome, are associated with higher cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Editorial Material
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Juliana Alexandra Hernandez Vargas, Oscar H. Franco
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Genetics & Heredity
Denise van der Drift, Mirjam Simoons, Birgit C. P. Koch, Gemma Brufau, Patrick Bindels, Maja Matic, Ron H. N. van Schaik
Summary: This study investigated the use of pharmacogenetics (PGx) in primary care in the Netherlands, finding that side effects were the main reason for testing and antidepressants were the most commonly tested drugs. The survey revealed a lack of knowledge among general practitioners (GPs) on when and how to use PGx, suggesting a need for more education on the topic.
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)
