Review
Immunology
Haiyang Kou, Lei Huang, Meng Jin, Qi He, Rui Zhang, Jianbing Ma
Summary: The study evaluates the effectiveness and safety of curcumin in rheumatoid arthritis patients. It finds that curcumin supplementation is beneficial for the treatment of rheumatoid arthritis and can improve inflammation levels and clinical symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Eduardo Villa, Teresita Sarquis, Jose de Grazia, Rene Nunez, Pablo Alarcon, Rodrigo Villegas, Carlos Guevara
Summary: Rheumatoid meningitis predominantly affects older adults with manifestations of transient neurological signs, systemic symptoms, episodic headache, and neuropsychiatric alterations. Maintenance therapy with high-dose corticosteroids is key for a better outcome in RM patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Jose Manuel Sanchez-Maldonado, Rafael Caliz, Miguel Angel Lopez-Nevot, Antonio Jose Cabrera-Serrano, Ana Moniz-Diez, Helena Canhao, Rob Ter Horst, Luca Quartuccio, Signe B. Sorensen, Bente Glintborg, Merete L. Hetland, Ileana Filipescu, Eva Perez-Pampin, Pablo Conesa-Zamora, Jerzy Swierkot, Alfons A. den Broeder, Salvatore De Vita, Eva Rabing Brix Petersen, Yang Li, Miguel A. Ferrer, Alejandro Escudero, Mihai G. Netea, Marieke J. H. Coenen, Vibeke Andersen, Joao E. Fonseca, Manuel Jurado, Katarzyna Bogunia-Kubik, Eduardo Collantes, Juan Sainz
Summary: This study confirmed the influence of the LINC02549 and LRRC55 loci on determining the response to TNFi in RA patients, while suggesting a weak effect of the MAFB and CNTN5 loci that require further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lilla Toth, Mark F. Juhasz, Laszlo Szabo, Alan Abada, Fruzsina Kiss, Peter Hegyi, Nelli Farkas, Gyoergy Nagy, Zsuzsanna Helyes
Summary: JAK inhibitors have been shown to be effective in treating rheumatoid arthritis (RA) by reducing joint inflammation and providing direct analgesic effect. This meta-analysis provides comprehensive evidence of the superiority of JAK inhibitors in improving patient-reported outcomes and disease activity indices in RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
S. Sajith Kumar, Madhumitha Haridoss, Krishnamurthy Venkataraman, Bhavani Shankara Bagepally
Summary: This study found that Janus kinase inhibitors (JAK-i) are cost-effective as a second-line treatment for rheumatoid arthritis (RA) after csDMARD failure, but not cost-effective after csDMARD-TNF-a-i failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Yanqing Liu, Xing Feng, Liu Yang, Yajing Wang, Juan Liu, Dongbao Zhao
Summary: This study aims to compare the efficacy and safety of Janus kinase inhibitors and leflunomide in the treatment of rheumatoid arthritis. The study will assess the quality of relevant research using systematic review and meta-analysis methods, and the results will be published in a peer-reviewed journal.
Review
Immunology
Esther F. Vicente-Rabaneda, Belen Atienza-Mateo, Ricardo Blanco, Lorenzo Cavagna, Julio Ancochea, Santos Castaneda, Miguel A. Gonzalez-Gay
Summary: Current evidence suggests that ABA may be a plausible alternative to treat RA patients with ILD. It would be highly desirable to develop prospective randomized controlled studies to confirm these findings.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
Claudia Monfroni Rocha, Alessandro Menna Alves, Beatriz Fabris Bettanin, Fernanda Majolo, Matthias Gehringer, Stefan Laufer, Marcia Ines Goettert
Summary: Jakinibs, including tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib, and filgotinib, have shown good results in achieving low disease activity and remission in patients with severe RA. Upadacitinib showed the best results among all jakinibs, while tofacitinib showed the best result in achieving remission. However, some jakinibs such as peficitinib, baricitinib, and filgotinib had no reported deaths in their studies, unlike tofacitinib which had 11 deaths. Despite the benefits, caution should be taken when using jakinibs in patients with severe liver and kidney disease.
INFLAMMOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Andrea Giachi, Massimo Cugno, Roberta Gualtierotti
Summary: Rheumatoid arthritis is not only related to joint issues, but also to cardiovascular disease. Chronic inflammation plays a key role in accelerating atherosclerosis. Disease-modifying anti-rheumatic drugs can improve cardiovascular risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Rheumatology
Francesca Motta, Nicola Bizzaro, Davide Giavarina, Franco Franceschini, Maria Infantino, Boaz Palterer, Gian Domenico Sebastiani, Carlo Selmi
Summary: This study analyzed the role of rheumatoid factor (RF) isotypes in the diagnosis and prognosis of rheumatoid arthritis (RA). The results showed that testing all RF isotypes with latex test or nephelometry provides the highest sensitivity, while determination of IgA isotype provides the highest specificity and positive likelihood ratio. However, RF isotypes do not provide relevant prognostic information due to limited and conflicting data.
Review
Clinical Neurology
Chester Yan Hao Ng, Sen Hee Tay, Roger S. McIntyre, Roger Ho, Wilson W. S. Tam, Cyrus S. H. Ho
Summary: There is a bidirectional association between rheumatoid arthritis (RA) and depression, with a higher risk for elderly individuals. RA patients with depression also face an increased risk of all-cause mortality.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Gastroenterology & Hepatology
Jasmijn A. M. Sleutjes, Jeanine E. Roeters van Lennep, Eric Boersma, Luis A. Menchen, Matthias Laudes, Klaudia Farkas, Tamas Molnar, Nicholas Alexander Kennedy, Marieke J. Pierik, C. Janneke van der Woude, Annemarie C. de Vries
Summary: Treatment with corticosteroids and tofacitinib significantly increases total cholesterol levels, while anti-TNF alpha treatment has no significant effect. Age is significantly related to treatment effects, but not other factors.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Lili Ye, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Chenxi Liu, Shengfang Bao, Jing Wu, Yanliang Jin
Summary: This study explored the role of DKK-1 and SOST in the pathogenesis of JIA. It was found that plasma levels of DKK-1 were significantly higher in JIA patients, especially in those with HLA-B27 positivity. After treatment, DKK-1 levels decreased significantly. However, there was no significant change in SOST levels among different JIA subtypes, before and after treatment, and healthy controls.
PEDIATRIC RESEARCH
(2023)
Review
Immunology
Liana Barenbrug, Maarten te Groen, Frank Hoentjen, Joris van Drongelen, Juul M. P. A. van den Reek, Irma Joosten, Elke M. G. J. de Jong, Renate G. van der Molen
Summary: The use of anti-TNF alpha agents during pregnancy in women with immune mediated inflammatory diseases, such as IBD, RA, and PS, is associated with an increased risk of preterm birth and infections in newborns, particularly for women with IBD. However, there was no increased risk for adverse pregnancy outcomes in women with RA and PS. Vaccination in children exposed to anti-TNF alpha seems to be safe and important in reducing the risk of infections.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Nutrition & Dietetics
Katja A. Schoenenberger, Anne-Catherine Schuepfer, Viktoria L. Gloy, Paul Hasler, Zeno Stanga, Nina Kaegi-Braun, Emilie Reber
Summary: Studies show that adopting anti-inflammatory diets (such as the Mediterranean diet, vegetarian diet, vegan diet, and ketogenic diet) can significantly reduce pain perception and benefit patients with rheumatoid arthritis.
Review
Rheumatology
Aurelie Beltai, Thomas Barnetche, Claire Daien, Cedric Lukas, Cecile Gaujoux-Viala, Bernard Combe, Jacques Morel
ARTHRITIS CARE & RESEARCH
(2020)
Review
Rheumatology
Julie Mielle, Alice Tison, Divi Cornec, Laetitia Le Pottier, Claire Daien, Jacques-Olivier Pers
Summary: The biological abnormalities associated with B lymphocytes in patients with primary Sjogren's syndrome are a hallmark of the disease, playing a critical role in the immunopathology. Current knowledge on B cells in this syndrome has been summarized and trials targeting B cells have been described.
Article
Rheumatology
Gaelle Vial, Anais De Pouilly, Laetitia Scouppe, Bruno Pereira, Claire Daien, Cedric Lukas, Adeline Ruyssen-Witrand, Pascale Vergne-Salle, Christophe Richez, Anne Tournadre
Article
Rheumatology
Gael Mouterde, Etienne Gamon, Nathalie Rincheval, Cedric Lukas, Raphaele Seror, Francis Berenbaum, Anne-Marie Dupuy, Claire Daien, Jean-Pierre Daures, Bernard Combe
JOURNAL OF RHEUMATOLOGY
(2020)
Review
Rheumatology
Guillaume Decarriere, Thomas Barnetche, Bernard Combe, Cecile Gaujoux-Viala, Cedric Lukas, Jacques Morel, Claire Daien
Summary: The study aimed to compare the safety and efficacy of different synthetic DMARDs in combination with advanced therapies for rheumatoid arthritis patients. Results showed that while MTX was slightly superior when combined with TNFi, leflunomide might be more superior when combined with rituximab.
ARTHRITIS CARE & RESEARCH
(2021)
Letter
Dermatology
B. Bergeret, L. -P. Secco, V. Pallure, C. Daien, Y. -M. Pers, J. Gottlieb, S. Barete, C. Girard, D. Lipsker, D. Bessis
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Rheumatology
Esther Ebstein, Marine Forien, Eleonora Norkuviene, Pascal Richette, Gael Mouterde, Claire Daien, Hang-Korng Ea, Claire Briere, Frederic Liote, Mykolas Petraitis, Thomas Bardin, Jeremy Ora, Philippe Dieude, Sebastien Ottaviani
Review
Immunology
Cedric Mercuzot, Simon Letertre, Claire Daien, Laetitia Zerkowski, Philippe Guilpain, Benjamin Terrier, Pierre Fesler, Camille Roubille
Summary: The review investigated the incidence and impact of comorbidities in AAV, as well as determinants of HRQoL. Findings showed increased cardiovascular risk, decreased HRQoL, and associated fatigue and anxiety in AAV patients. Factors like fatigue, mood disorders, sleep disturbance, and unemployment were linked to decreased PCS and MCS.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Mielle Julie, Nutz Anaiz, Guillpain Philippe, Audo Rachel, Gaujoux-Viala Cecile, Combe Bernard, Morel Jacques, Daien Claire
IMMUNOLOGIC RESEARCH
(2021)
Review
Nutrition & Dietetics
Yann Nguyen, Johanna Sigaux, Jean-Guillaume Letarouilly, Pauline Sanchez, Sebastien Czernichow, Rene-Marc Flipo, Martin Soubrier, Luca Semerano, Raphaele Seror, Jeremie Sellam, Claire Daien
Summary: Oral vitamin supplementation did not show significant reduction in RA activity, however, folic acid supplementation can prevent methotrexate-related side effects, and vitamin D can prevent musculo-skeletal complications in patients with vitamin D deficiency.
Article
Medicine, Research & Experimental
C. Daien, J. Tan, R. Audo, J. Mielle, L. E. Quek, J. R. Krycer, A. Angelatos, M. Duraes, G. Pinget, D. Ni, R. Robert, M. J. Alam, M. C. B. Amian, F. Sierro, A. Parmar, G. Perkins, S. Hoque, A. K. Gosby, S. J. Simpson, R. Ribeiro, C. R. Mackay, L. Macia
Summary: Acetate has been shown to promote the differentiation of important immune cells B10 cells, both in mice and human blood cells, by increasing the production of acetylcoenzyme A and promoting posttranslational lysine acetylation. These effects contribute to maintaining immune balance and suggest that delivery of acetate, either directly or through dietary supplementation, could be a promising approach in restoring B10 cells in noncommunicable diseases.
Article
Immunology
Julie Mielle, Jacques Morel, Jamila ElHmioui, Bernard Combe, Laurence Macia, Valerie Dardalhon, Naomi Taylor, Rachel Audo, Claire Daien
Summary: Alterations in cell metabolism can affect the differentiation of immune cells and provide new therapeutic opportunities for immune-related diseases. This study identifies glutaminolysis and the mTOR/GSK3 signaling pathway as critical regulators of IL-10 production in regulatory B cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Rheumatology
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Summary: This study evaluated the safety and efficacy of ABX464 in patients with moderate-to-severe active rheumatoid arthritis. The results showed that ABX464 at a 50 mg dose was safe, well tolerated, and showed promising efficacy. The 100 mg dose had a high dropout rate due to gastrointestinal adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Rachel Audo, Pauline Sanchez, Benjamin Riviere, Julie Mielle, Jian Tan, Cedric Lukas, Laurence Macia, Jacques Morel, Claire Immediato Daien
Summary: This study found that RA patients have altered colonic tight junction proteins and increased serum biomarkers of intestinal permeability. These results suggest a link between impaired gut integrity and systemic inflammation in RA.
Article
Rheumatology
Alessia Alunno, Elena Nikiphorou, Elena Philippou, Claire Daien, Dieter Wiek, Marios Kouloumas, Maurizio Cutolo