Review
Cell Biology
Milena Iwaszko, Sylwia Bialy, Katarzyna Bogunia-Kubik
Summary: IL-4 and IL-13 are key mediators of allergic inflammation and have been implicated in the development of autoimmune diseases. Recent studies suggest that they may play a significant role in downregulating inflammatory processes underlying rheumatoid arthritis pathogenesis.
Article
Biochemistry & Molecular Biology
Ana Triguero-Martinez, Emilia Roy-Vallejo, Nuria Montes, Hortensia de la Fuente, Ana Maria Ortiz, Santos Castaneda, Isidoro Gonzalez-Alvaro, Amalia Lamana
Summary: A study found that genetic variants in the LGALS1 gene are associated with Gal1 serum levels, and these genetic variants can explain the differences in Gal1 levels among patients, with higher levels of Gal1 being associated with lower levels of IL-6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ning-Sheng Lai, Hui-Chun Yu, Hsien-Yu Huang Tseng, Chia-Wen Hsu, Hsien-Bin Huang, Ming-Chi Lu
Summary: This study found that serum BDNF levels were significantly elevated in RA patients compared to controls, with lower levels in patients with anxiety or receiving biologics treatment. BDNF had varying effects on different MAPK pathways and regulated the expression of multiple genes, leading to increased expression of specific genes in RA patient T cells. BDNF also increased the expression of inflammatory cytokines in Jurkat cells and secretion of IL-2 and IFN-gamma in activated peripheral blood mononuclear cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Samantha Rodriguez-Muguruza, Antonio Altuna-Coy, Veronica Arreaza-Gil, Marina Mendieta-Homs, Sonia Castro-Oreiro, Maria Jose Poveda-Elices, Nuria del Castillo-Pinol, Ramon Fontova-Garrofe, Matilde R. Chacon
Summary: This study identified new serum biomarkers for ERA using metabolomics and constructed a biomarker panel composed of glyceric acid, lactic acid, and 3-hydroxisovaleric acid, which shows potential for improving the early clinical diagnosis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Adela Navratilova, Viktor Becvar, Hana Hulejova, Michal Tomcik, Lucie Stolova, Herman Mann, Olga Ruzickova, Olga Sleglova, Jakub Zavada, Karel Pavelka, Jiri Vencovsky, Ladislav Senolt, Lucie Andres Cerezo
Summary: IL-40 is up-regulated in seropositive ERA and decreases after conventional therapy. Neutrophils are an important source of IL-40 in RA, and its release is potentiated by cytokines and NETosis. IL-40 may play a role in ERA.
Article
Biology
Petra Simac, Dijana Perkovic, Ivona Bozic, Nada Bilopavlovic, Dinko Martinovic, Josko Bozic
Summary: This study found that serum levels of the secretory protein Adropin were significantly lower in patients with rheumatoid arthritis (RA) compared to healthy controls, and were negatively correlated with total cholesterol, HbA1c, fasting glucose, and insulin resistance index. After adjusting for confounding factors, serum Adropin levels remained significantly associated with fasting glucose and HbA1c levels.
Article
Medical Laboratory Technology
Luping Gong, Yinxin Zhou, Shanjun Shi, Lina Ying, Yan Li, Mingcai Li
Summary: IL-41 expression is increased in the serum of RA patients and positively correlated with disease-related parameters. IL-41 may serve as a potential new diagnostic biomarker for RA.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Dong Mao, Hong Jiang, Fei Zhang, Haoyu Yang, Xiaodong Fang, Qian Zhang, Gang Zhao
Summary: This study found that HDAC2 is highly expressed in synovial tissue of rheumatoid arthritis (RA) patients and exacerbates the progression of RA by regulating the IL-17-CCL7 signaling pathway. This suggests that HDAC2 may be a promising therapeutic target for RA treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Paradowska-Gorycka, Anna Wajda, Ewa Rzeszotarska, Tomasz Kmiolek, Barbara Stypinska, Ewa Dudek, Katarzyna Romanowska-Prochnicka, Piotr Syrowka
Summary: Circulating free-cell miRNAs have become increasingly important as potential non-invasive biomarkers, particularly in the field of oncology. This research aimed to investigate the association between selected miRNAs in serum and the expression of Th17/Treg transcription factors, as well as clinical features, in rheumatoid arthritis (RA) patients. The study found that miR-10 was only detected in RA patients and its expression was correlated with IL-35 serum concentration and STAT5a mRNA level. Additionally, miR-326 was significantly upregulated in RA patients with rheumatoid factor presence. The differential association of transcription factor expression with serum miRNA levels may have implications for the diagnosis and progression of RA and osteoarthritis (OA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dogukan Yilmaz, Katariina Niskanen, Emel Gonullu, Taina Tervahartiala, Ulvi Kahraman Gursoy, Timo Sorsa
Summary: This study aimed to investigate the levels of various proteins in the serum and saliva of patients with periodontitis and rheumatoid arthritis (RA). The results showed higher levels of certain proteins, such as aMMP-8, in saliva of periodontitis patients compared to controls. However, the rheumatologic status did not seem to affect the salivary levels of these proteins. Serum levels of neutrophil proteases were increased in RA patients compared to systemically healthy groups.
Article
Medicine, General & Internal
Sebastian C. Rodriguez-Garcia, Nuria Montes, Jose Ivorra-Cortes, Ana Triguero-Martinez, Luis Rodriguez-Rodriguez, Isabel Castrejon, Loreto Carmona, Isidoro Gonzalez-Alvaro
Summary: The study compared the capacity of various disease activity indices to evaluate changes in function, IL-6 levels, and radiographic progression in early and established rheumatoid arthritis. The HUPI index outperformed others in identifying changes in physical function and radiographic progression, performing similarly to SDAI for IL-6 serum levels.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
A. N. Burska, J. J. El-Jawhari, J. Wu, R. J. Wakefield, H. Marzo-Ortega, P. G. Conaghan, P. Emery, F. Ponchel, J. E. Freeston
Summary: Serum RANKL levels can predict rheumatoid arthritis diagnosis with added value over clinical biomarkers, especially in seronegative IA patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: We developed a gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Our findings demonstrate the potential of HSPC-mediated IL-1RA delivery as a therapeutic modality for suppressing tissue and organ inflammation in diverse immune-related diseases involving IL-1-driven inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: This study developed a lentivirus-mediated gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. The HSPC-mediated IL-1RA delivery showed therapeutic efficacy in various IL-1-driven inflammation models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Rheumatology
Morten B. Pedersen, Peter Thinggaard, Rinie Geenen, Marianne U. Rasmussen, Maarten De Wit, Lyn March, Philip Mease, Ernest Choy, Philip G. Conaghan, Lee Simon, Anne Faber Hansen, Simon Tarp, Berit Schiottz-Christensen, Carsten B. Juhl, Sabrina M. Nielsen, Kirstine Amris, Robin Christensen
Summary: Biopsychosocial rehabilitation has a significant but clinically small beneficial effect on pain relief among patients with inflammatory arthritis and osteoarthritis (OA), with no difference in harm.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Geriatrics & Gerontology
Swati Chopra, Rama T. Kodali, Gretl A. McHugh, Philip G. Conaghan, Sarah R. Kingsbury
Summary: This scoping review summarizes the evidence related to home-based health care interventions for older adults with chronic musculoskeletal pain. The findings suggest that physical therapy, psychotherapy, and multimodal therapy are effective self-management options.
JOURNAL OF GERIATRIC PHYSICAL THERAPY
(2023)
Article
Rheumatology
P. G. Conaghan, L. Abraham, L. Viktrup, J. C. Cappelleri, C. Beck, A. G. Bushmakin, M. Berry, J. Jackson
Summary: Across five European countries, the use of non-pharmacological and pharmacological treatments increases with greater osteoarthritis (OA) disease severity. Patients with more severe disease place a greater demand on healthcare resources, with consultations, tests, and hospital visits increasing with severity.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
John B. Arnold, Jill Halstead, Carmen Martin-Hervas, Andrew J. Grainger, Anne-Maree Keenan, Catherine L. Hill, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond
Summary: This study compared MRI-detected structural abnormalities in patients with symptomatic midfoot osteoarthritis, patients with persistent midfoot pain, and asymptomatic controls. The findings suggest a prevalence of osteoarthritis in individuals with persistent midfoot pain but no signs of OA on radiography, particularly in specific joints. However, the MRI abnormalities were not strongly associated with pain or foot-related disability.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
David Demanse, Franziska Saxer, Patrick Lustenberger, Philipp Nikolaus, Ilja Rasin, Damian F. Brennan, Ronenn Roubenoff, Sumehra Premji, Philip G. Conaghan, Matthias Schieker
Summary: This study used two different machine learning algorithms to identify distinct patient clusters in osteoarthritis population, in order to enable the development of effective therapies. Both deep embedded clustering and multiple factor analysis with clustering approaches identified comorbid patients with higher BMI and low physical activity, as well as young/physically active and elderly/physically inactive clusters. These findings could be helpful for early trial design to enrich for patients who may specifically benefit from disease-modifying treatments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, Philip G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Marjan A. Versnel, Edward M. Vital
Summary: This study developed evidence-based points to consider for the measurement and reporting of IFN-I assays in clinical research. The study provides recommendations on terminology, assay characteristics, and reporting practices, as well as explores the clinical applications of IFN-I assays in diagnosis and outcome assessments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Gurjit S. Kaeley, Georg Schett, Philip G. Conaghan, Dennis McGonagle, Frank Behrens, Philippe Goupille, Corine Gaillez, Bhumik Parikh, Catherine Bakewell
Summary: This study evaluated the treatment response of enthesitis in PsA patients treated with secukinumab or adalimumab for 52 weeks. The results showed that both drugs had similar efficacy in resolving enthesitis, including time to resolution. The authors concluded that inhibition of IL-17 with secukinumab reduced clinical enthesitis similarly to TNF-alpha inhibition with adalimumab.
Editorial Material
Medicine, General & Internal
Helen Saul, Samantha Cassidy, Brendan Deeney, Jemma Kwint, Philip Conaghan
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Tarimobo M. Otobo, Mirkamal Tolend, Arthur B. Meyers, Iwona Sudol-Szopinska, Sayali Joshi, Jennifer Stimec, Nele Herregods, Jacob L. Jaremko, Shirley M. L. Tse, Nigil Haroon, Rahim Moineddin, Nikolay Tzaribachev, Simone Appenzeller, Michal Znajdek, Manuela Perez, Aloysius E. Ligha, Lennart Jans, Emilio Inarejos J. Clemente, Pamela Weiss, Olympia Papakonstantinou, Eva Kirkhus, Marion A. J. van Rossum, Dax G. Rumsey, John Carrino, Jonathan D. Akikusa, Philip G. Conaghan, Andrea S. Doria
Summary: This study used an adaptive multicriteria decision analysis to determine the relative weights of items in the JAMRIS-SIJ scoring system for juvenile idiopathic arthritis. Experts completed a conjoint analysis survey, comparing hypothetical patient profiles to determine the point value of the measurement items. The study found differences in relative weights among the JAMRIS-SIJ measurement items and validated the weighted scoring system.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Health Care Sciences & Services
Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stephane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Segloene Robin Lagandre, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, Tarek Sharshar
JMIR RESEARCH PROTOCOLS
(2023)
Article
Orthopedics
S. R. Kingsbury, L. K. K. Smith, R. Pinedo-Villanueva, A. Judge, R. West, J. M. Wright, M. H. Stone, P. G. Conaghan
Summary: This study conducted a systematic review and analysis of large datasets to provide recommendations for follow-up after total hip and knee arthroplasty. The recommendations suggest regular follow-up from 1 to 10 years post-surgery, with clinical and radiological evaluation at 10 years.
Article
Rheumatology
Gui Tran, Elizabeth M. A. Hensor, Sarah R. Kingsbury, Philip O'Connor, Paul Cowling, Philip G. Conaghan
Summary: This study aimed to determine if groups of ultrasound-based shoulder pathologies exist and how they relate to treatment outcomes. The results showed that current ultrasound-based classification methods cannot predict medium-term treatment outcomes for shoulder pain. Therefore, the role of routine diagnostic ultrasound for shoulder pain needs to be considered, and evidence-based therapies for specific pathologies should be established.
Article
Rheumatology
Lara S. Chapman, Jennifer Jones, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Catherine Hofstetter, Toby O. Smith, John B. Arnold, Marian T. Hannan, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Yvonne M. Golightly, Peter Tugwell, Dorcas Beaton, Philip G. Conaghan, Philip S. Helliwell, Heidi J. Siddle
Summary: The OMERACT Foot and Ankle Working Group is developing a core outcome set for foot and ankle disorders in rheumatic and musculoskeletal diseases, however, there is a lack of high-quality evidence on the effectiveness of treatments for these disorders. A scoping review was conducted to identify outcome domains in the existing literature and feedback was obtained on the next steps of the project. The findings from the review and the feedback will contribute to the development of the core outcome set.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Orthopedics
Bahram Mohajer, Kamyar Moradi, Ali Guermazi, Mahsa Dolatshahi, Frank W. Roemer, Hamza A. Ibad, Ghazaal Parastooei, Philip G. Conaghan, Bashir A. Zikria, Mei Wan, Xu Cao, Joao A. C. Lima, Shadpour Demehri
Summary: Statin use is associated with a slight decrease in MRI-based measures of thigh muscle quality over 4 years. However, considering statins' substantial cardiovascular benefits, these slight muscle changes may be relatively less important in overall patient care.
SKELETAL RADIOLOGY
(2023)
Article
Rheumatology
T. Rabin, G. De Marco, S. R. Dubash, F. Shuweihdi, H. Marzo-Ortega, P. Emery, F. Ponchel, V. Goeb
Summary: This pilot study analyzed the abnormalities in circulating lymphocyte subsets in axial spondyloarthritis (axSpA) and investigated their potential association with the response to biologic disease-modifying anti-rheumatic drugs (b-DMARDs). The results showed dysregulation of lymphocyte subsets in axSpA and different associations with clinical response to IL17i and TNFi.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)