Article
Medicine, General & Internal
Hye-Won Yun, Chun-Ja Kim, Ji-Won Kim, Hyoun-Ah Kim, Chang-Hee Suh, Ju-Yang Jung
Summary: The study found that male sex, low BMI, and use of TNF inhibitors were associated with low muscle mass in RA patients, while old age and low BMI were associated with sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Enriqueta Vallejo-Yague, Theresa Burkard, Burkhard Moller, Axel Finckh, Andrea M. Burden
Summary: The study showed that obese PsA and RA patients had worse disease activity and lower quality of life compared to those with normal weight.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Juan L. Prados-Ojeda, Rogelio Luque-Luque, Rafael M. Gordillo-Urbano, Ipek Guler, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras
Summary: The study found a higher prevalence of subclinical psychotic symptoms in patients with RA and SpA compared to the general population, indicating a potential association between inflammation and depression/subclinical psychotic symptoms. Despite similar mental dimension scores in the SF-12 Health Survey, patients showed greater distress due to the presence of symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Cynthia S. Crowson, Tina M. Gunderson, Hayley J. Dykhoff, Elena Myasoedova, Elizabeth J. Atkinson, Vanessa L. Kronzer, Caitrin M. Coffey, John M. Davis
Summary: This study comprehensively assessed the burden of multimorbidity in patients with rheumatoid arthritis (RA) and found that RA patients have a higher prevalence of multimorbidity compared to non-RA patients. Interstitial lung disease, fibromyalgia, osteoarthritis, and osteoporosis were common morbidities in RA patients.
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Rheumatology
Marco Garrido-Cumbrera, Helena Marzo-Ortega, Laura Christen, Pedro Plazuelo-Ramos, Dale Webb, Clare Jacklin, Shantel Irwin, Laurent Grange, Souzi Makri, Elsa Frazao Mateus, Serena Mingolla, Katy Antonopoulou, Sergio Sanz-Gomez, Jose Correa-Fernandez, Loreto Carmona, Victoria Navarro-Compan
Summary: The COVID-19 pandemic has had a significant impact on patients with rheumatic and musculoskeletal diseases (RMDs) in Europe, leading to disruptions in healthcare services, worsening lifestyle habits, and negative effects on overall health, well-being, and mental health. Additionally, there has been a lack of appropriate information reaching patients regarding COVID-19.
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Sung Soo Ahn, Hye Min Kim, Younhee Park
Summary: Plasma tumour M2-PK levels are significantly correlated with disease activity in RA patients, and a decline in levels was observed after inflammation reduction. Tumour M2-PK, when combined with ESR and CRP, provides a high predictive value for distinguishing disease activity status in RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Rheumatology
Hakan Emmungil, Ufuk Ilgen, Sezin Turan, Ozge Kilic
Summary: Loneliness in Turkish patients with RA, AS, and PsA is associated with depression, anxiety, lack of social support, disability, higher number of drugs used, and lower education levels, but not with disease activity.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Ivan Ferraz-Amaro, Alfonso Corrales, Belen Atienza-Mateo, Nuria Vegas-Revenga, Diana Prieto-Pena, Julio Sanchez-Martin, Cristina Almeida, Juan Carlos Quevedo-Abeledo, Ricardo Blanco, Miguel A. Gonzalez-Gay
Summary: The study compared the predictive capacities of SCORE and SCORE2 in identifying RA patients with subclinical atherosclerosis. It was found that while both algorithms showed similar performance in predicting the presence of carotid plaque, SCORE2 identified a significantly higher proportion of RA patients at high or very high risk of CVD compared to the original SCORE.
Article
Medicine, General & Internal
Byung-Wook Song, A-Ran Kim, Yun-Kyung Kim, Geun-Tae Kim, Eun-Young Ahn, Min-Wook So, Seung-Geun Lee
Summary: This study investigated the diagnostic performance of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in the diagnosis of rheumatoid arthritis (RA) in subjects with undifferentiated inflammatory arthritis (UIA). The results showed that MLR may be used as a complementary diagnostic indicator for RA diagnosis in patients with UIA.
Article
Nutrition & Dietetics
Marc Villedon de Naide, Bruno Pereira, Daniel Courteix, Frederic Dutheil, Lucie Cassagnes, Yves Boirie, Martin Soubrier, Anne Tournadre
Summary: Both RA and SpA patients exhibit correlations between IMAT and VAT, as well as total lean mass, but not with total body fat. Total lean mass mediated the effects of VAT on IMAT. Calf muscle area was correlated with total lean mass, while fat area was associated with total body fat and subcutaneous fat.
Article
Nutrition & Dietetics
Christina Heidt, Ulrike Kaemmerer, Manfred Fobker, Andreas Rueffer, Thorsten Marquardt, Monika Reuss-Borst
Summary: This study investigated the association between zonulin, calprotectin, and lipopolysaccharide (LPS) levels in RA patients. Serum zonulin levels were abnormal with longer disease duration, and fecal zonulin levels were inversely associated with age. There was a strong association between fecal and serum calprotectin, and between fecal calprotectin and LPS in males, suggesting the potential of fecal calprotectin as a specific biomarker for intestinal inflammation in RA.
Article
Rheumatology
Takuro Nii, Yuichi Maeda, Daisuke Motooka, Mariko Naito, Yuki Matsumoto, Takao Ogawa, Eri Oguro-Igashira, Toshihiro Kishikawa, Makoto Yamashita, Satoshi Koizumi, Takashi Kurakawa, Ryu Okumura, Hisako Kayama, Mari Murakami, Taiki Sakaguchi, Bhabatosh Das, Shota Nakamura, Yukinori Okada, Atsushi Kumanogoh, Kiyoshi Takeda
Summary: This study reveals the genetic differences between Prevotella copri (P. copri(RA)) derived from rheumatoid arthritis (RA) patients and P. copri (P. copri(HC)) derived from healthy controls. The results show that P. copri(RA) induces more severe inflammation in arthritis models and can activate host immune cells. These findings contribute to the understanding of the pathogenesis of rheumatoid arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Danlei Zhou, Emily H. King, Simon Rothwell, Olga Krystufkova, Antonella Notarnicola, Samantha Coss, Rabheh Abdul-Aziz, Katherine E. Miller, Amanda Dang, G. Richard Yu, Joanne Drew, Emeli Lundstrom, Lauren M. Pachman, Gulnara Mamyrova, Rodolfo Curiel, Boel De Paepe, Jan L. De Bleecker, Antony Payton, William Ollier, Terrance P. O'Hanlon, Ira N. Targoff, Willy A. Flegel, Vidya Sivaraman, Edward Oberle, Shoghik Akoghlanian, Kyla Driest, Charles H. Spencer, Yee Ling Wu, Haikady N. Nagaraja, Stacy P. Ardoin, Hector Chinoy, Lisa G. Rider, Frederick W. Miller, Ingrid E. Lundberg, Leonid Padyukov, Jiri Vencovsky, Janine A. Lamb, Chack-Yung Yu
Summary: C4A deficiency is relevant in dermatomyositis, HLA-DRB1*03 is important in IBM, and both C4A deficiency and HLA-DRB1*03 contribute interactively to the risk of polymyositis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Paola de Pablo, Stefan Serban, Isabel Lopez-Oliva, Joanna Rooney, Kirsty Hill, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich
Summary: This study investigated the impact of periodontal treatment on disease activity in patients with active rheumatoid arthritis (RA) through a randomized controlled trial. The results showed that periodontal therapy can significantly improve periodontal disease outcomes and overall RA disease activity, although complete resolution of periodontal inflammation was difficult to achieve in some cases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhi Yi Wong, Eloise Nee, Mark Coles, Christopher D. Buckley
Summary: Fibroblasts are not only responsible for making and modifying the extracellular matrix, but also play important roles in defining tissue microenvironments and supporting immune responses. They display a spectrum of functional states and can switch between these states depending on the needs of the organ. Understanding the factors that affect their development and functional states is crucial for restoring homeostasis in maladapted tissues.
Article
Rheumatology
Diana Ekman, Bengt Sennblad, Ann Knight, Asa Karlsson, Solbritt Rantapaa-Dahlqvist, Ewa Berglin, Bernd Stegmayr, Bo Baslund, Oyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Marten Segelmark, Sophie Ohlsson, Aladdin J. Mohammad, Anna Svard, Rille Pullerits, Hans Herlitz, Annika Soderbergh, Roald Omdal, Roland Jonsson, Lars Ronnblom, Per Eriksson, Kerstin Lindblad-Toh, Johanna Dahlqvist
Summary: The study aims to identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. The research analyzed a SNP dataset derived from DNA sequencing and genotyping of AAV cases and controls. The results showed that there are differences in genetic predisposition and disease mechanisms between males and females with MPO-ANCA-positive AAV, and that double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing implications for clinical follow-up and treatment.
Article
Immunology
Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. R. Clark, Karim Raza, Christopher D. D. Buckley
Summary: This study investigates how lactate regulates fibroblast and macrophage movement, IL-6 secretion, and metabolism via specific lactate transporters. The results show that lactate has opposite effects on the effector functions of these two cell types.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Immunology
Axel Finckh, Adrian Ciurea, Catherine E. Raptis, Andrea Rubbert-Roth
Summary: Immune-mediated inflammatory diseases (IMIDs) are a diverse group of diseases characterized by immune dysregulation, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. The prevalence of IMIDs ranges between 5% and 7% in developed countries. The use of immunomodulatory medications in the management of IMIDs can weaken the immune response and increase the risk of severe outcomes from COVID-19, as well as reduce the efficacy of COVID-19 vaccination. This article summarizes the current literature on COVID-19 outcomes, vaccination responses, and the impact of immunomodulatory therapies in patients with rheumatologically dominated IMIDs, and provides vaccination recommendations for individuals with IMID.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Imogen Wells, Dawit T. Zemedikun, Gwenda Simons, Rebecca J. Stack, Christian D. Mallen, Karim Raza, Marie Falahee
Summary: First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) are increasingly involved in prediction and prevention studies. The patients' decision-making preferences, interest in FDRs taking a predictive test, and beliefs about the effects of risk information on their relatives are factors that influence the likelihood of patients communicating RA risk information to their FDRs.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Rheumatology
Burkhard Moller, Godehard A. Scholz, Jennifer Amsler, Adrian Ciurea, Raphael Micheroli, Michael J. Nissen, Eleftherios Papagiannoulis, Christoph Blapp, Almut Scherer, Nikhil Yawalkar
Summary: This study compared the effectiveness of the first biologic DMARD (bDMARD) in patients with low and high joint counts. The results showed that bDMARD had similar drug retention rates in patients with low and high joint counts. Furthermore, bDMARD retention was significantly better when administered with conventional synthetic DMARD co-therapy.
Article
Rheumatology
Louise Linde, Lykke Midtboll Ornbjerg, Cecilie Heegaard Brahe, Johan Karlsson Wallman, Daniela Di Giuseppe, Jakub Zavada, Isabel Castrejon, Federico Diaz-Gonzalez, Ziga Rotar, Matija Tomsic, Bente Glintborg, Bjorn Gudbjornsson, Arni Jon Geirsson, Brigitte Michelsen, Eirik Klami Kristianslund, Maria Jose Santos, Anabela Barcelos, Dan Nordstrom, Kari K. Eklund, Adrian Ciurea, Michael Nissen, Servet Akar, Lise Hejl Hyldstrup, Niels Steen Krogh, Merete Lund Hetland, Mikkel Ostergaard
Summary: This study investigated the real-world effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA) and its association with treatment line and reasons for withdrawal. The results showed similar drug retention rates for the second and third TNFi, but lower remission rates for the third TNFi. Additionally, higher remission rates were observed for the second TNFi if the withdrawal reason from the preceding TNFi was adverse events (AE).
Article
Cell Biology
Kelsey N. S. Thompson, Kevin S. E. Bonham, Nicholas E. J. Ilott, Graham J. Britton, Paula J. Colmenero, Samuel J. J. Bullers, Lauren J. McIver, Siyuan H. Ma, Long H. Nguyen, Andrew Filer, India Brough, Claire Pearson, Caroline Moussa, Vinod H. Kumar, Lilian H. A. Lam, Matthew A. Jackson, April Pawluk, Serafim R. Kiriakidis, Peter C. Taylor, Lucy R. P. Wedderburn, Brian R. Marsden, Stephen P. J. Young, Dan R. G. Littman, Jeremiah J. Faith, Arthur G. Pratt, Paul Bowness, Karim Raza, Fiona Powrie, Curtis Huttenhower
Summary: Musculoskeletal diseases impact 20% of adults globally. The connection between gut microbiome and inflammatory conditions, like arthritis, has not been fully understood. The Inflammatory Arthritis Microbiome Consortium analyzed 440 stool samples and found differential microbiome composition and functional processes in patients with inflammatory arthritis compared to healthy individuals. This research enhances our understanding of how systemic inflammation during arthritis affects the gut ecosystem.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Rheumatology
H. Kim, D. Saygin, C. Douglas, J. A. McGrath, J. Wilkerson, B. Erman, A. Pistorio, A. M. Reed, C. V. Oddis, F. W. Miller, J. Vencovsky, N. Ruperto, R. Aggarwal, L. G. Rider
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
N. Alchus Laiferova, M. Nemec, L. Vernerova, T. Kurdiova, M. Balazova, M. Vokurkova, S. Oreska, M. Klein, M. Spiritovic, M. Tomcik, J. Vencovsky, J. Ukropec, B. Ukropcova
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Barbora Hermankova, Sabina Oreska, Maja Spiritovic, Hana Storkanova, Karel Pavelka, Ladislav Senolt, Jiri Vencovsky, Radim Becvar, Michal Tomcik
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)