Article
Immunology
Pin-Hung Lin, Po-Ju Hsiao, Ching-Fu Pan, Ming-Tsan Liu, Jann-Tay Wang, Chi Ching, Fang-Yi Wu, Yi-Hsuan Lin, Yu-Chan Yang, Le-Yin Hsu, Hung-Chih Yang, Un-In Wu
Summary: Repeated annual influenza vaccinations are associated with lower vaccine-induced antibody responses and a higher frequency of vaccine-specific regulatory T cells. This may dampen the antibody response to inactivated influenza vaccine.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Celeste J. Romano, Clinton Hall, Zeina G. Khodr, Anna T. Bukowinski, Gia R. Gumbs, Ava Marie S. Conlin
Summary: This study examined the association between receiving pandemic H1N1 (pH1N1) vaccines in consecutive influenza seasons and adverse pregnancy outcomes among vaccine-compliant pregnant military women. The results showed no significant association between receiving pH1N1-containing vaccine during pregnancy and spontaneous abortion or birth defects. Therefore, vaccination against pH1N1 in pregnancy is supported regardless of prior influenza season vaccination history.
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Gabriel Figueroa-Parra, Jorge Antonio Esquivel-Valerio, Leticia Santoyo-Fexas, Andrea Moreno-Salinas, Carmen Magdalena Gamboa-Alonso, Ana Laura De Leon-Ibarra, Dionicio Angel Galarza-Delgado
Summary: This study investigated the knowledge and attitudes about influenza vaccination among patients with rheumatic diseases and found that concerns about safety, efficacy, side effects, fear of the vaccine, and knowledge of cost can diminish vaccine uptake. These factors are related to confidence, complacency, and convenience as components of vaccine hesitancy in this population.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhuofan Li, Ki-Hye Kim, Noopur Bhatnagar, Bo Ryoung Park, Subbiah Jeeva, Yu-Jin Jung, Jannatul Raha, Sang-Moo Kang, Xinyuan Chen
Summary: This study presents a physical radiofrequency adjuvant (RFA) that can conveniently and effectively enhance the immunogenicity and efficacy of H5N1 vaccine. The RFA treatment on the skin induces thermal stress to enhance immune responses and does not cause significant adverse reactions. The RFA significantly increases antibody titers, reduces viral titers, body weight loss, and improves survival rates in murine models. It has no gender difference in its effects.
Article
Infectious Diseases
Damien Friel, Mary Co, Thierry Ollinger, Bruno Salaun, Anne Schuind, Ping Li, Karl Walravens, Francis A. Ennis, David W. Vaughn
Summary: This study found broadly comparable non-neutralizing immune responses following vaccination with non-adjuvanted and AS03-adjuvanted A(H1N1)pdm09 formulations, including increased activity against a related vaccine strain.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Rheumatology
Liat Iancovici, Dina Khateeb, Ofer Harel, Regina Peri, Gleb Slobodin, Yoav Hazan, Doron Melamed, Aharon Kessel, Yotam Bar-On
Summary: This study found that RA patients treated with Janus kinase inhibitors have a suppressed humoral response following BNT162b2 vaccination, as indicated by reduced levels of anti-spike antibodies and neutralization capacity. Additionally, these patients exhibited reduced B cell responsiveness to the SARS-CoV-2 spike protein.
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Tatiana Sofia Rodriguez-Reyna, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Diana Lizzeth Hernandez-Garcia, Eduardo M. Choreno-Parra, Yalbi I. Balderas-Martinez, Mariana Esther Martinez-Sanchez, Eduardo Marquez-Garcia, Edda Sciutto, Jose Moreno-Rodriguez, Jose Omar Barreto-Rodriguez, Hazel Vazquez-Rojas, Gustavo Ivan Centeno-Saenz, Nestor Alvarado-Pena, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, David Galeana-Cadena, Gabriela Hernandez, Criselda Mendoza-Milla, Andrea Dominguez, Julio Granados, Lula Mena-Hernandez, Luis Angel Perez-Buenfil, Guillermo Dominguez-Cheritt, Carlos Cabello-Gutierrez, Cesar Luna-Rivero, Jorge Salas-Hernandez, Patricio Santillan-Doherty, Justino Regalado, Angelica Hernandez-Martinez, Lorena Orozco, Federico Avila-Moreno, Ethel A. Garcia-Latorre, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: By comparing patients with COVID-19 and pandemic influenza A(H1N1), it was found that influenza patients had more severe respiratory symptoms, while COVID-19 patients more often experienced dry cough and gastrointestinal symptoms. The immune responses also differed between the two diseases, with pandemic influenza A(H1N1) characterized by higher levels of certain cytokines and COVID-19 displaying a distinct immune profile with increased Th1 and Th2 cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yating You, Xiaoheng Li, Binglin Chen, Xuan Zou, Gang Liu, Xinxin Han
Summary: A cross-sectional study was conducted among older adults in southern China to investigate their knowledge, attitude, and practice (KAP) towards influenza virus and vaccination. The results showed that 55.6% of participants had received influenza vaccination before and 46.6% had taken influenza vaccination during the pandemic in 2020. Only one-fifth of participants were aware of the severe complications that can occur with severe influenza. 88.3% of participants believed that older adults should receive influenza vaccination. COVID-19 vaccination history was associated with receiving influenza vaccination. Efforts should be made to promote free influenza vaccination and improve KAP among older adults through regular health education events.
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Immunology
Ignacio Hernandez-Garcia, Moises Garces-Redondo, Judit Espinosa-Rueda, Joana Rodriguez-Montolio, Irantzu Bengoa-Urrengoechea, Carlos Aibar-Remon
Summary: In the context of the COVID-19 pandemic, the co-circulation of influenza and SARS-CoV-2 viruses may have severe complications for vulnerable populations. The influenza vaccination coverage in a Spanish multiple sclerosis unit for the 2020-2021 season was 55.3%, with factors associated with vaccination being female gender, previous influenza vaccine uptake, and being born in Spain.
Article
Rheumatology
Gabriela A. Munhoz, Nadia E. Aikawa, Clovis A. Silva, Sandra G. Pasoto, Tatiana N. Pedrosa, Luciana P. C. Seguro, Eloisa Bonfa, Eduardo F. Borba
Summary: This study aimed to determine the impact of lupus nephritis at disease onset on short-term accrual of 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) domains. The study found that patients with renal involvement had higher disease activity and required more treatment at disease onset, while patients without renal involvement also experienced damage in the early stages of the disease. Therefore, close monitoring and tailored treatment for lupus patients without renal involvement are important.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Carla G. S. Saad, Matheus S. R. Silva, Percival D. Sampaio-Barros, Julio C. B. Moraes, Claudia G. Schainberg, Celio R. Goncalves, Andrea Y. Shimabuco, Nadia E. Aikawa, Emily F. N. Yuki, Sandra G. Pasoto, Leonard V. K. Kupa, Renato K. Aoyama, Carlo S. R. Araujo, Clovis A. Silva, Ana C. Medeiros-Ribeiro, Eloisa Bonfa
Summary: This study evaluated the humoral responses to the SARS-CoV-2 vaccine in patients with spondyloarthritis and found that therapy had an impact on the immune response. TNF inhibitors attenuated the immune response, while sulfasalazine had a positive impact on vaccine antibody production.
Biographical-Item
Endocrinology & Metabolism
Vanda Jorgetti, Sampaio-Barros Pd, Shinjo Sk, Eloisa Bonfa
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Pediatrics
Ana P. Sakamoto, Clovis A. Silva, Aline G. Islabao, Glaucia Novak, Beatriz Molinari, Paulo K. Nogueira, Rosa M. R. Pereira, Claudia Saad-Magalhaes, Gleice Clemente, Daniela P. Piotto, Nadia E. Aikawa, Ana C. Pitta, Vitor C. Trindade, Simone Appenzeller, Luciana M. Carvalho, Carlos N. Rabelo-Junior, Adriana R. Fonseca, Flavio R. Sztajnbok, Maria C. Santos, Blanca E. Bica, Evaldo G. Sena, Ana J. Moraes, Melissa M. Fraga, Teresa C. Robazzi, Paulo F. Spelling, Iloite M. Scheibel, Andre S. Cavalcanti, Erica N. Matos, Luciano J. Guimaraes, Flavia P. Santos, Licia M. H. Mota, Eloisa Bonfa, Maria T. Terreri
Summary: This study evaluated stages of chronic kidney disease (CKD) in pediatric systemic lupus erythematosus (SLE) patients and identified risk factors for CKD. The study found that hypertension, biopsy-proven proliferative nephritis, and lack of antimalarial use were associated with an increased risk of CKD in these patients.
PEDIATRIC NEPHROLOGY
(2023)
Article
Rheumatology
Luis Alonso Gonzalez, Graciela S. Alarcon, Guillermina B. Harvey, Rosana Quintana, Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Gloria Vasquez, Luis J. Catoggio, Mercedes A. Garcia, Eduardo F. Borba, Nilzio A. Da Silva, Joao C. Tavares Brenol, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Virginia Pascual-Ramos, Mary-Carmen Amigo, Leonor A. Barile-Fabris, Ignacio Garcia De La Torre, Jose Alfaro-Lozano, Maria Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A. Pons-Estel
Summary: This study aimed to determine the predictors of severe autoimmune hemolytic anemia (AIHA) occurrence and its impact on damage accrual and mortality in patients with systemic lupus erythematosus (SLE). The study found that male sex and higher disease activity at diagnosis were associated with a shorter time to severe AIHA occurrence. Although not statistically significant, hematological abnormalities at SLE diagnosis showed a certain trend toward predicting the occurrence of severe AIHA in a shorter time. Severe AIHA did not seem to impact damage and mortality.
Article
Nutrition & Dietetics
Bianca Depieri Balmant, Danielle Cristina Fonseca, Ana Paula Aguiar Prudencio, Ilanna Marques Rocha, Leticia Callado, Juliana Tepedino Martins Alves, Raquel Susana Matos de Miranda Torrinhas, Eduardo Ferreira Borba, Dan Linetzky Waitzberg
Summary: This study investigated the relationship between gut microbiota, intestinal permeability, food intake, and inflammatory markers in inactive SLE patients. The results showed that Megamonas genus was enriched in the inactive SLE group, with Megamonas funiformis associated with all evaluated laboratory tests. Plasma zonulin was associated with C3 levels, and sodium intake was negatively associated with C3 and C4 levels. These findings suggest that increased Megamonas funiformis abundance, elevated plasma zonulin, and higher sodium intake may contribute to reduced C3 complement levels in women with inactive SLE.
Article
Rheumatology
Clovis Artur Silva, Leonard de Vinci Kanda Kupa, Ana Cristina Medeiros-Ribeiro, Sandra Gofinet Pasoto, Carla Goncalves Schahin Saad, Emily Figueiredo Neves Yuki, Joaquim Ivo Vasques Dantas Landim, Victor Hugo Ferreira e Leda, Luisa Sacchi de Camargo Correia, Artur Fonseca Sartori, Carolina Campagnoli Machado Freire Martins, Carolina Torres Ribeiro, Filipe Waridel, Victor Adriano de Oliveira Martins, Samuel Katsuyuki Shinjo, Danieli Castro Oliveira Andrade, Percival Degrava Sampaio Barros, Eduardo Ferreira Borba Neto, Nadia Emi Aikawa, Eloisa Bonfa
Summary: The study aimed to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with autoimmune rheumatic diseases (ARD). The results showed that there was no significant difference in the frequency and symptoms of post-acute COVID-19 between ARD patients and non-ARD controls, suggesting that vaccination has a minimal impact on post-acute COVID-19 in ARD patients.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Bruno Gualano, Sofia M. Sieczkowska, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Bruna C. Mazzolani, Fabiana I. Smaira, Nadia E. Aikawa, Leonard V. K. Kupa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Pedro C. Hallal, Hamilton Roschel, Eloisa Bonfa
Summary: Physical activity is associated with improved immunogenicity after vaccination in patients with autoimmune rheumatic diseases (ARD). A study found that physically active patients had higher odds of better antibody responses to CoronaVac booster dose compared to inactive patients. These results support the recommendation of physical activity to enhance vaccination responses in immunocompromised individuals.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Immunology
Lucas Peixoto Sales, Bidossessi Wilfried Hounkpe, Mariana Ortega Perez, Valeria Falco Caparbo, Diogo Souza Domiciano, Eduardo Ferreira Borba, Georg Schett, Camille Pinto Figueiredo, Rosa Maria Rodrigues Pereira
Summary: This study analyzed the gene expression of classical monocytes in erosive and non-erosive rheumatoid arthritis (RA) patients and found that alterations in genes related to inflammation and bone formation might play an important role in the pathophysiology of bone erosions in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Karina Rossi Bonfiglioli, Ana Cristina de Medeiros Ribeiro, Ana Paula Carnieletto, Ivanio Pereira, Diogo Souza Domiciano, Henrique Carrico da Silva, Alisson Pugliesi, Leticia Rocha Pereira, Maria Fernanda Resende Guimaraes, Rina Dalva Neubarth Giorgi, Ana Paula Monteiro Gomides Reis, Claiton Viegas Brenol, Paulo Louzada-Junior, Maria de Fatima Lobato da Cunha Sauma, Sebastiao Cezar Radominski, Licia Maria Henrique da Mota, Geraldo da Rocha Castelar-Pinheiro
Summary: This study aimed to determine the prevalence of extra-articular manifestations (ExtRA) in rheumatoid arthritis (RA) patients and its association with demographic and clinical variables. The results showed that the overall prevalence of ExtRA in the cohort was 23.4%, and it was significantly associated with age, disease duration, serological markers, disease activity, and treatment options.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Fabiana Infante Smaira, Bruna Caruso Mazzolani, italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Sofia M. Sieczkowska, Nadia E. Aikawa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Leonard de Vinci Kanda Kupa, Pedro C. Hallal, Hamilton Roschel, Bruno Gualano, Eloisa Bonfa
Summary: This study investigated the association between physical activity and immunogenicity in SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases before and after receiving the Sinovac inactivated vaccine. The results showed no association between physical activity and immunogenicity before and after vaccination. These findings suggest that previous SARS-CoV-2 infection may override the positive association between physical activity and antibody responses seen in immunocompromised individuals following vaccination, and this association does not extend to natural immunity.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Rheumatology
Jozelio Freire de Carvalho, Carolina Bonato Armond de Oliveira, Rogerio Vilas Boas, Matheus Franklin Vicente Matias, Larissa Matos Carvalho Bastos
Summary: This study presents two cases where patients developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA) with postural orthostatic tachycardia syndrome (POTS) after silicone breast implant (SBI), and their condition improved after the removal of the implant.
EUROPEAN JOURNAL OF RHEUMATOLOGY
(2023)