4.7 Letter

Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement

期刊

ANNALS OF THE RHEUMATIC DISEASES
卷 70, 期 10, 页码 1876-U184

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2010.148247

关键词

-

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Medicine, Research & Experimental

The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting

Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Marco Matucci-Cerinic, Mirko Manetti

Summary: Systemic sclerosis is a complex connective tissue disorder characterized by multisystem clinical manifestations. Myofibroblasts play a crucial role in the fibrosis of systemic sclerosis, and inhibiting their differentiation and accumulation may be an effective therapeutic strategy.

CURRENT MOLECULAR MEDICINE (2022)

Article Oncology

Quality of life improvement in breast cancer survivors affected by upper limb lymphedema through a novel multiperspective physical activity methodology: a monocentric pilot study

Giuditta Carretti, Daniela Mirandola, Francesca Maestrini, Lisa Sequi, Sara Germano, Maria Grazia Muraca, Guido Miccinesi, Mirko Manetti, Mirca Marini

Summary: This study describes the effects of a specific adapted physical activity (APA) intervention on lymphedema-related morphofunctional alterations and quality of life (QoL) in breast cancer survivors. The results suggest that APA can improve wrist mobility, pain perception, depression, and QoL.

BREAST CANCER (2022)

Article Cell Biology

Morphologic evidence of telocytes in human thyroid stromal tissue

Irene Rosa, Lidia Ibba-Manneschi, Daniele Guasti, Giuliano Perigli, Maria-Simonetta Faussone-Pellegrini, Mirko Manetti

Summary: Telocytes play a significant role in the stromal microenvironment of various organs in the human body, but their presence in the endocrine glands has been largely unexplored. This study provides the first comprehensive demonstration of the presence of telocytes in the human thyroid stroma and lays the groundwork for further research on their implications in glandular homeostasis and pathophysiology.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Article Environmental Sciences

Survey on Psychological Well-Being and Quality of Life in Visually Impaired Individuals: Dancesport vs. Other Sound Input-Based Sports

Giuditta Carretti, Daniela Mirandola, Eleonora Sgambati, Mirko Manetti, Mirca Marini

Summary: The practice of dancesport may have a stronger positive impact on the psychological well-being and quality of life of visually impaired individuals than other sound input-based sports.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Rheumatology

Soluble guanylate cyclase stimulation fosters angiogenesis and blunts myofibroblast-like features of systemic sclerosis endothelial cells

Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Dilia Giuggioli, Mirko Manetti, Marco Matucci-Cerinic

Summary: Pharmacological sGC stimulation effectively improves the angiogenic performance and reduces the myofibroblast-like profibrotic phenotype of SSc-MVECs, providing new evidence for repurposing sGC stimulators for the treatment of SSc.

RHEUMATOLOGY (2023)

Review Biochemistry & Molecular Biology

Current Trends in Vascular Biomarkers for Systemic Sclerosis: A Narrative Review

Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Eloisa Romano, Mirko Manetti

Summary: Systemic sclerosis (SSc, scleroderma) is a rare connective tissue disease characterized by immune dysregulation, small vessel vasculopathy, impaired angiogenesis, and fibrosis. Microvascular impairment is the initial event of the disease and is linked to disabling and life-threatening clinical manifestations. Despite available treatment options, managing SSc-related vascular disease remains challenging. Vascular biomarkers have shown promise in assessing disease progression, predicting prognosis, and guiding therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Cell Biology

Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts

Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti

Summary: This study reveals a previously unrecognized relationship between lactic acidosis and the generation of a new CAF-like cell subpopulation from adipocytic precursor cells, which sustains tumor malignancy.
Editorial Material Biology

Advances in Systemic Sclerosis: From Pathogenetic Pathways toward Novel Therapeutic Targets

Eloisa Romano, Irene Rosa, Mirko Manetti

LIFE-BASEL (2023)

Article Cell Biology

Immunohistochemical and ultrastructural identification of telocytes in the lamina propria of human vaginal mucosa

Irene Rosa, Patrizia Nardini, Bianca Saveria Fioretto, Daniele Guasti, Eloisa Romano, Eleonora Sgambati, Mirca Marini, Mirko Manetti

Summary: Telocytes (TCs) have been found to exist in the stromal tissue of the human vaginal mucosa and are characterized by their presence in the perivascular networks and release of extracellular vesicles. Further investigation is needed to determine the functions of TCs in vaginal mucosal homeostasis and pathophysiology.

ACTA HISTOCHEMICA (2023)

Article Cell Biology

Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis

Irene Rosa, Eloisa Romano, Bianca Saveria Fioretto, Khadija El Aoufy, Silvia Bellando-Randone, Marco Matucci-Cerinic, Mirko Manetti

Summary: Currently, only a few studies have investigated the role of the lymphatic vascular system in the pathogenesis of systemic sclerosis (SSc). This study aimed to explore the possibility of lymphatic endothelial cells undergoing an endothelial-to-myofibroblast transition (Ly-EndMT) and contributing to skin fibrosis in SSc. The results demonstrated the presence of lymphatic endothelial cells in intermediate stages of the Ly-EndMT process exclusively in the fibrotic skin of SSc patients, suggesting that Ly-EndMT might be a previously overlooked pathogenic process linking peripheral microlymphatic dysfunction and skin fibrosis development in SSc.
暂无数据