Article
Multidisciplinary Sciences
Yibo He, Changrong Ge, Alex Moreno-Giro, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lonnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmstrom, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, Rene E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Summary: Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), their in vivo functions remain unclear. In this study, monoclonal ACPAs derived from RA patients were expressed in mice and their functions were analyzed. One of the antibodies, clone E4, showed a protective effect against antibody-induced arthritis in mice, suggesting therapeutic potential for ACPAs in RA.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Divya Shankar, Giovanna Merchand-Reyes, Nathaniel J. Buteyn, Ramasamy Santhanam, Huiqing Fang, Krishan Kumar, Xiaokui Mo, Latha P. Ganesan, Wael Jarjour, Jonathan P. Butchar, Susheela Tridandapani
Summary: Overactivation of immune responses is a characteristic of autoimmune diseases, and BET inhibition with PLX51107 can reduce this immune response, making it a potential therapeutic target for diseases such as rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Guenter Steiner
Summary: This study aimed to investigate the diagnostic performance of anti-CCP2 and anti-CCP3 IgG and IgA assays in patients with early RA, with a focus on the prognostic value of IgA ACPA. The results showed that the anti-CCP2 IgG and IgA assays had high specificity but low sensitivity. The anti-CCP3.1 assay had slightly higher sensitivity but lower specificity compared to the anti-CCP2 IgG assay.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sunhee Jang, Eui-Jong Kwon, Jennifer Jooha Lee
Summary: Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, and recent advancements have shed light on the underlying mechanisms, providing new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Matthew K. Mcelwee, Thamotharampillai Dileepan, Shawn A. Mahmud, Marc K. Jenkins
Summary: This study found that HLA-DR-bound citrullinated peptides are not neo-antigens and can induce varying degrees of immune tolerance. This may pose a barrier to rheumatoid arthritis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Serena Bugatti, Laura Bogliolo, Antonio Manzo, Ludovico De Stefano, Paolo Delvino, Francesca Motta, Carlomaurizio Montecucco
Summary: ACPA positivity in early RA patients is associated with ongoing bone mineral density loss at the spine despite treatment, highlighting the need for strict monitoring for osteoporosis development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
YunLing Xu, Zhongmin Zhang, Jiaolong He, Zhenxing Chen
Summary: Global research on macrophage-related rheumatoid arthritis is rapidly advancing, with the United States, the Netherlands, and the journal Arthritis and Rheumatism being major contributors. The polarization of macrophages in RA has received increasing attention in recent years, and research has expanded into areas such as fundamental research, inflammation control, and drug delivery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Liam O'Neil, Mackenzie A. Jantz, Marvin J. Fritzler, Hani El-Gabalawy
Summary: While alternative autoimmunity and ANA positivity are widely prevalent in First Nations populations, including asymptomatic, seronegative FDR, expansion of alternative autoimmunity does not occur in parallel with ACPA expansion in FDR and is restricted to patients with established RA.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyan Chen, Guangsheng Du, Shuting Bai, Liu Dijia, Chenglong Li, Yingying Hou, Yuandong Zhang, Zhirong Zhang, Tao Gong, Yao Fu, Massimo Bottini, Xun Sun
Summary: The study aimed at exploring the therapeutic effects and tolerogenic mechanism of a novel tolerogenic polypeptide vaccine, showing synergistic effects on regulatory T cells, promotion of IL-10 secretion, reduction of pro-inflammatory cytokines, and antibodies in experimental arthritis. This work could shed light on the development of tolerogenic therapeutics as novel immunotherapies for rheumatoid arthritis.
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Pureun Won, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Dong Hyun Sohn, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju
Summary: The study demonstrated that monoclonal antibody 12G1 can directly detect citrullinated proteins in rheumatoid arthritis (RA) target tissue and sera, indicating its potential in arthritis induction. 12G1 may be useful for diagnosing RA, including seronegative RA, and could help to understand the pathophysiological role of citrullination in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tanglin Ouyang, Liyu Song, Huiling Fang, Ji Tan, Yue Zheng, Jinping Yi
Summary: Rheumatoid arthritis is a chronic autoimmune disease that primarily affects synovial joints, leading to synovial inflammation and joint damage. Timely and effective treatment is crucial for disease control, but misdiagnosis or delayed treatment often results in worsened condition and poor prognosis, significantly impacting patients' quality of life.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Dandan Zong, Beibei Huang, Young Li, Yichen Lu, Nan Xiang, Chuang Guo, Qian Liu, Qing Sha, Pengcheng Du, Qiaoni Yu, Wen Zhang, Pengfei Cai, Yanping Sun, Jinhui Tao, Xiaomei Li, Shanbao Cai, Kun Qu
Summary: This study revealed a CRP-induced pathogenic chromatin dysregulation signature in monocytes from RA patients, suggesting potential therapeutic targets for the disease.
Review
Biochemistry & Molecular Biology
Rephany Fonseca Peixoto, Carlos Ewerton Maia Rodrigues, Pedro Henrique de Sousa Palmeira, Fernando Cezar Comberlang Queiroz Davis dos Santos, Tatjana Keesen de Souza Lima, Alessandra de Sousa Braz
Summary: This review examines the current evidence on immunomodulation in the treatment of rheumatoid arthritis, focusing on conventional drugs and novel biological agents. The goal of treatment is to achieve sustained clinical remission and/or reduce disease activity. Various disease-modifying antirheumatic drugs, such as methotrexate, leflunomide, and targeted synthetic and biological agents, are used to modulate the immune response in RA patients.
Article
Rheumatology
Cyril Clavel, Laurie Ceccato, Florence Anquetil, Guy Serre, Mireille Sebbag
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Review
Immunology
Teresa Rodriguez-Calvo, Somayeh Sabouri, Florence Anquetil, Matthias G. von Herrath
AUTOIMMUNITY REVIEWS
(2016)
Review
Immunology
Kimia T. Maleki, Martin Cornillet, Niklas K. Bjorkstrom
CLINICAL IMMUNOLOGY
(2016)
Article
Rheumatology
Martin Cornillet, Soufiane Ajana, Adeline Ruyssen-Witrand, Arnaud Constantin, Yannick Degboe, Alain Cantagrel, Olivier Meyer, Guy Serre, Leonor Nogueira
Article
Immunology
Florence Anquetil, Somayeh Sabouri, Charles Thivolet, Teresa Rodriguez-Calvo, Jose Zapardiel-Gonzalo, Natalie Amirian, Darius Schneider, Ericka Castillo, Yasaman Lajevardi, Matthias G. von Herrath
JOURNAL OF AUTOIMMUNITY
(2017)
Article
Immunology
Martin Cornillet, Fruzsina Babos, Anna Magyar, Mireille Sebbag, Evelyne Verrouil, Ferenc Hudecz, Guy Serre, Leonor Nogueira
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Matthieu Ribon, Sarra Seninet, Julie Mussard, Mireille Sebbag, Cyril Clavel, Guy Serre, Marie-Christophe Boissier, Luca Semerano, Patrice Decker
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Gastroenterology & Hepatology
Martin Cornillet, Hannes Jansson, Marie Schaffer, Laura Hertwig, Lena Berglin, Christine L. Zimmer, Helene Johansson, Ewa Ellis, Bengt Isaksson, Faviel F. Gonzalez-Galarza, Derek Middleton, Karl-Johan Malmberg, Ernesto Sparrelid, Niklas K. Bjorkstrom
Article
Multidisciplinary Sciences
Jean-Paul Motta, Alexandre Denadai-Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Seguy, Noa Mathurine-Thomas, Heather J. Galipeau, Delphine Bonnet, Laurent Alric, Andre G. Buret, John L. Wallace, Antoine Dufour, Elena F. Verdu, Morley D. Hollenberg, Eric Oswald, Matteo Serino, Celine Deraison, Nathalie Vergnolle
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Christopher Maucourant, Iva Filipovic, Andrea Ponzetta, Soo Aleman, Martin Cornillet, Laura Hertwig, Benedikt Strunz, Antonio Lentini, Bjorn Reinius, Demi Brownlie, Angelica Cuapio, Eivind Heggernes Ask, Ryan M. Hull, Alvaro Haroun-Izquierdo, Marie Schaffer, Jonas Klingstrom, Elin Folkesson, Marcus Buggert, Johan K. Sandberg, Lars Eriksson, Olav Rooyackers, Hans-Gustaf Ljunggren, Karl-Johan Malmberg, Jakob Michaelsson, Nicole Marquardt, Quirin Hammer, Kristoffer Stralin, Niklas K. Bjorkstrom
SCIENCE IMMUNOLOGY
(2020)
Article
Cell Biology
Xiaojun Jiang, Annika Bergquist, Britt-Sabina Loscher, Geetha Venkatesh, Jeff E. Mold, Kristian Holm, Jon K. Laerdahl, Sigrid S. Skanland, Kimia T. Maleki, Martin Cornillet, Kjetil Tasken, Andre Franke, Tom H. Karlsen, Niklas K. Bjorkstrom, Espen Melum
Summary: A heterozygous germline missense mutation in the CD100 gene was found in a family with PSC, leading to T cell functional defects and increased proliferation as well as impaired interferon-gamma production. Mice with homologous mutation showed a higher susceptibility to develop severe cholangitis, which could be attenuated by transferring wild-type T cells. The study suggests a potential therapeutic role for T cells in protecting against PSC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Christina Villard, Ingalill Friis-Liby, Fredrik Rorsman, Karouk Said, Anna Warnqvist, Martin Cornillet, Stergios Kechagias, Nils Nyhlin, Marten Werner, Izabella Janczewska, Therese Hagstrom, Emma Nilsson, Annika Bergquist
Summary: This study prospectively evaluated the effectiveness of yearly MRI/MRCP surveillance in detecting cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC) and found it to be ineffective in detecting cancer early enough to support long-term survival. Personalized follow-up strategies and improved diagnostic methods for PSC-related CCA are needed.
JOURNAL OF HEPATOLOGY
(2023)
Article
Rheumatology
Johan Ronnelid, Monika Hansson, Linda Mathsson-Alm, Martin Cornillet, Evan Reed, Per-Johan Jakobsson, Lars Alfredsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Karin Lundberg, Lars Klareskog
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Medicine, General & Internal
M. Ribon, S. Seninet, K. Matyja, M. Sebbag, C. Clavel, J. Mussard, G. Serre, M. C. Boissier, P. Decker
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2016)