Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Matilda Morin, Thomas Frisell, Olof Stephansson, Karin Hellgren
Summary: This study aimed to assess the risks of adverse pregnancy outcomes in women with axial spondyloarthritis and investigate how the outcomes varied over time and with anti-rheumatic treatment. The results showed increased risks of preterm birth, pre-eclampsia, elective caesarean delivery, and serious infant infection in women with axial spondyloarthritis compared to the general population. However, there was a trend of improvement in pregnancy outcomes over time, coinciding with increased use of biological DMARDs.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Dermatology
Alina I. Marusina, Antonio Ji-Xu, Stephanie T. Le, Atrin Toussi, Lam C. Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R. Leal, Nikolay Y. Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Bruggen, Iannis E. Adamopoulos, Alexander A. Merleev, Johann E. Gudjonsson, Emanual Maverakis
Summary: ERAP1, ERAP2, and LNPEP, which are aminopeptidases, play a role in autoimmune diseases. The expression of ERAP2 is increased while ERAP1 is decreased in psoriasis patients with autoimmune-linked variants of ERAP. Different layers of skin cells show different expression patterns of aminopeptidases, and in psoriasis, basal keratinocytes also express CCL2 and IL-15. In addition, ERAP2-high skin fibroblasts also express more CXCL14.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Rheumatology
Sinead Maguire, Fiona Wilson, Phil Gallagher, Finbar O'Shea
Summary: The prevalence of central obesity is high in axial spondyloarthritis, especially among women. Central obesity has a significant impact on patient outcomes, regardless of sex. It is associated with worse quality of life, greater impairment of functional ability, and a trend towards worse disease activity.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Monique Reijnierse, Xenofon Baraliakos, Juergen Braun, Floris A. van Gaalen, Sofia Ramiro
Summary: Objective: We analyzed the trabecular bone density of patients with r-axSpA using low-dose CT scans and assessed the inter-reader reliability. Our results showed that ldCT measurement of HU is a feasible method to assess vertebral bone density in r-axSpA with excellent inter-reader reliability from C3 to L5.
Article
Rheumatology
Mark C. Hwang, MinJae Lee, Lianne S. Gensler, Matthew A. Brown, Amirali Tahanan, Mohammad H. Rahbar, Theresa Hunter, Mingyan Shan, Mariko L. Ishimori, John D. Reveille, Michael H. Weisman, Thomas J. Learch
Summary: This study identified four distinct patterns of spinal disease progression in ankylosing spondylitis patients. Factors associated with higher spinal disease burden groups include male gender, longer disease duration, elevated CRP and smoking history. Independent confirmation in other AS cohorts is needed to confirm these radiographic patterns.
Article
Rheumatology
Tae-Han Lee, Bon San Koo, Bora Nam, Yun Jin Kim, Donghee Son, Seunghun Lee, Kyung Bin Joo, Tae-Hwan Kim
Summary: This study investigated spinal radiographic progression in ankylosing spondylitis (AS) patients and found that the progression rate is highest in patients aged 30-39 years. Understanding the relationship between age and spinal structural damage progression could improve the understanding of the natural course of AS.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
Mouhammad Kridin, Khalaf Kridin, Arnon D. Cohen, Howard Amital, Abdulla Watad
Summary: Amyloidosis is a risk for patients with AS, and those with comorbid amyloidosis are at a higher risk of end-stage renal disease necessitating dialysis. Awareness of this complication is important for rheumatologists managing AS patients.
Article
Orthopedics
Lei Han, Renfu Quan, Zhenle Pei, Guoping Cao, Yungen Hu, Jingjing Liu
Summary: Bilateral synchronous total hip arthroplasty was found to be effective for patients with ankylosing spondylitis, as it significantly reduced pain, improved hip function, and had few postoperative complications.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Rosalinde Stal, Xenofon Baraliakos, Juergen Braun, Monique Reijnierse, Caroline Bastiaenen, Sofia Ramiro, Floris A. van Gaalen
Summary: The study investigated the association between inflammation and lower trabecular bone density (TBD) in radiographic axial spondyloarthritis (r-axSpA), and whether a lower TBD increases the likelihood of 2-year bone formation at the same vertebra. The study found that inflammation was associated with lower TBD, but lower TBD itself did not increase the risk of new bone formation at the same vertebra.
Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Matilda Morin, Karin Hellgren, Ulf Lindstroem, Thomas Frisell
Summary: This study aims to identify the risk factors for ankylosing spondylitis (AS) during perinatal and early life, while controlling for family-shared confounding using a sibling comparison design. The study found that having older siblings and a history of tonsillectomy in childhood were independently associated with the development of AS, even after adjusting for family-shared factors in a sibling comparison analysis.
Letter
Rheumatology
Juergen Braun, Robert B. M. Landewe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Robert B. M. Landewe, Juergen Braun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
T. Rusman, M. A. C. van der Weijden, M. T. Nurmohamed, C. J. van Denderen, R. B. M. Landewe, P. M. Bet, C. M. A. van der Bijl, C. J. Van der Laken, I. E. van der Horst-Bruinsma
Summary: The study found that 16 weeks of etanercept treatment did not have an impact on disease activity, the chance of biological treatment, or radiographic progression in patients with suspected non-radiographic axial spondyloarthritis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Juergen Braun, Xenofon Baraliakos
Article
Health Care Sciences & Services
Helena Santos, Ana Rita Henriques, Jaime Branco, Pedro M. Machado, Helena Canhao, Fernando M. Pimentel-Santos, Ana Maria Rodrigues
Summary: The study found that both spondyloarthritis and chronic low back pain have similar impacts on health-related quality of life (HRQoL), including mental, physical, and social domains. Patients with spondyloarthritis and chronic low back pain reported significantly lower HRQoL compared to those without rheumatic diseases. Modifiable factors such as multimorbidity, active disease, obesity, and regular physical exercise were associated with HRQoL in these conditions.
QUALITY OF LIFE RESEARCH
(2023)
Review
Rheumatology
Dafne Capelusnik, Diego Benavent, Desiree van der Heijde, Robert Landewe, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compan, Sofia Ramiro
Summary: This study conducted a systematic literature review to summarize the relationship between early treatment and treatment clinical response in patients with SpA. It found that early treatment was associated with better outcomes in patients with non-radiographic axSpA and symptom duration of less than 5 years, but no differences in response to treatment were found in radiographic axSpA or in patients with longer symptom duration.
Article
Rheumatology
Casper Webers, Uta Kiltz, Juergen Braun, Desiree van der Heijde, Annelies Boonen
Summary: Treating active SpA improves depressive symptoms, especially with TNF inhibitors (TNFis) which have a stronger effect mainly due to their impact on disease activity.
Article
Rheumatology
Josef S. Smolen, Robert B. M. Landewe, Sytske Anne Bergstra, Andreas Kerschbaumer, Alexandre Sepriano, Daniel Aletaha, Roberto Caporali, Christopher John Edwards, Kimme L. Hyrich, Janet E. Pope, Savia de Souza, Tanja A. Stamm, Tsutomu Takeuchi, Patrick Verschueren, Kevin L. Winthrop, Alejandro Balsa, Joan M. Bathon, Maya H. Buch, Gerd R. Burmester, Frank Buttgereit, Mario Humberto Cardiel, Katerina Chatzidionysiou, Catalin Codreanu, Maurizio Cutolo, Alfons A. den Broeder, Khadija El Aoufy, Axel Finckh, Joao Eurico Fonseca, Jacques-Eric Gottenberg, Espen A. Haavardsholm, Annamaria Iagnocco, Kim Lauper, Zhanguo Li, Iain B. McInnes, Eduardo F. Mysler, Peter Nash, Gyula Poor, Gorica G. Ristic, Felice Rivellese, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Nikolay Stoilov, Anja Strangfeld, Annette van der Helm-van Mil, Elsa van Duuren, Theodora P. M. Vliet Vlieland, Rene Westhovens, Desiree van der Heijde
Summary: This study provides an update on the management recommendations for rheumatoid arthritis (RA) based on the latest developments in the field. The recommendations cover various aspects including medication use, combination therapy, treatment strategies, and dose reduction. The consensus was reached on 5 overarching principles and 11 specific recommendations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Alexandre Sepriano, Andreas Kerschbaumer, Sytske Anne Bergstra, Josef S. Smolen, Desiree van der Heijde, Roberto Caporali, Christopher J. Edwards, Patrick Verschueren, Savia de Souza, Janet Pope, Tsutomu Takeuchi, Kimme Hyrich, Kevin L. Winthrop, Daniel Aletaha, Tanja Stamm, Jan W. Schoones, Robert B. M. Landewe
Summary: This study conducted a systematic literature review (SLR) to evaluate the safety of synthetic and biological disease-modifying antirheumatic drugs (DMARDs) for the management of rheumatoid arthritis (RA). The results indicated that bDMARDs were associated with an increased risk of serious infections compared to csDMARDs, while JAK inhibitors (JAKi) showed higher risk of herpes zoster infections. The risks of malignancies, major adverse cardiovascular events (MACE), and venous thromboembolism (VTE) were similar among different treatments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Evelyn Hsieh, Dzifa Dey, Rebecca Grainger, Mengtao Li, Pedro M. Machado, Manuel F. Ugarte-Gil, Jinoos Yazdany
Summary: Although the public health emergency associated with the COVID-19 pandemic has ended, challenges remain for individuals with rheumatic diseases. Disruptions in healthcare and medication supply shortages have impacted the health and mental well-being of these individuals. Telemedicine and changes in healthcare utilization have also affected rheumatology practices globally. Efforts are needed to improve healthcare access, stabilize rheumatology drug supplies, and implement evidence-based vaccination practices to reduce COVID-19 morbidity and mortality among individuals with rheumatic diseases.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Miriam Frenken, Benedikt Ostendorf, Ralph Brinks, Christoph Schleich, Lena M. Wilms, Stefan Vordenbaeumen, Anja Mueller-Lutz, Jutta G. Richter, Oliver Sander, Gerald Antoch, Matthias Schneider, Xenofon Baraliakos, Daniel B. Abrar, Philipp Sewerin
Summary: This study evaluated the effect of combination therapy with methotrexate and adalimumab versus methotrexate alone on cartilage status in patients with early rheumatoid arthritis using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). The results showed that combination therapy resulted in improved cartilage composition, while methotrexate alone did not have any effect on cartilage composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Xenofon Baraliakos, Atul Deodhar, Desiree van der Heijde, Marina Magrey, Walter P. Maksymowych, Tetsuya Tomita, Huji Xu, Ute Massow, Carmen Fleurinck, Alicia M. Ellis, Thomas Vaux, Julie Shepherd-Smith, Alexander Marten, Lianne S. Gensler
Summary: Bimekizumab (BKZ), a monoclonal antibody that inhibits IL-17F and IL-17A, demonstrated sustained efficacy in patients with axial spondyloarthritis (axSpA) at Week 52. The dual inhibition of IL-17A and IL-17F resulted in significant improvements compared to placebo and the safety profile was consistent with previous findings.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Volker Kinast, Ioana Andreica, Gerrit Ahrenstorf, Andre Goemer, Carina Elsner, Sarah Schlienkamp, Jil Alexandra Schrader, Mara Klohn, Rainer G. Ulrich, Ruth Broering, Florian W. R. Vondran, Daniel Todt, Patrick Behrendt, Ulf Dittmer, Axel Hamprecht, Torsten Witte, Xenofon Baraliakos, Eike Steinmann
Summary: This study aimed to investigate the influence of JAK inhibitors on HEV replication. The results showed that JAKi treatment increased HEV replication and disrupted the immune response triggered by HEV. Therefore, monitoring potential HEV infections is necessary during JAKi treatment and when liver enzymes are elevated.
ANTIVIRAL RESEARCH
(2023)
Letter
Rheumatology
Xenofon Baraliakos, Effie Pournara, Laura C. Coates, Victoria Navarro-Compan, Ricardo Blanco, Eamonn O'Brien, Barbara Schulz, Robert Landewe