Article
Rheumatology
M. Mona, S. Mondello, J. Y. Hyon, W. Saleh, K. Han, H-J Lee, Y-J Ha, E. H. Kang, Y. J. Lee, S. Cha
Summary: Anti-M3R has high specificity and sensitivity in Sjogren's syndrome, assisting in diagnosis and correlating with clinical manifestations.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Chenyang Lu, Xuenan Pi, Wangdong Xu, Pingying Qing, Honghu Tang, Yanhong Li, Yi Zhao, Xiao Liu, Huairong Tang, Yi Liu
Summary: This study dynamically assessed the characteristics of TCR diversity in primary Sjogren's syndrome (SS) patients and found that they had lower TCR diversity but a higher frequency of public clones. TCR variations associated with SS were correlated with dental caries, thrombocytopenia, hepatocholangeitis, and other factors. The TCR abnormalities remained during follow-up, and the sensitive subgroup showed increased TCR diversity after treatment.
Article
Rheumatology
Gudny Ella Thorlacius, Lina Hultin-Rosenberg, Johanna K. Sandling, Matteo Bianchi, Juliana Imgenberg-Kreuz, Pascal Pucholt, Elke Theander, Marika Kvarnstrom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Daniel Hammenfors, Kathrine Skarstein, Malin V. Jonsson, Eva Baecklund, Lara A. Aqrawi, Janicke Liaaen Jensen, Oyvind Palm, Andrew P. Morris, Jennifer R. S. Meadows, Solbritt Rantapaa-Dahlqvist, Thomas Mandl, Per Eriksson, Lars Lind, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Lars Ronnblom, Marie Wahren-Herlenius, Gunnel Nordmark
Summary: The clinical presentation of primary Sjogren's syndrome (pSS) varies widely. A multicentre study identified two patient subgroups based on the presence of SSA/SSB antibodies and genetic markers in the HLA region, with strong association signals found in HLA-DQA1 locus for the antibody-positive subgroup. Replication confirmed the association with MHC class I and II variants, indicating distinct clinical manifestations in pSS subgroups.
Article
Immunology
Christina-Maria Flessa, Evangelia Zampeli, Maria-Eleftheria Evangelopoulos, Vasilis Natsis, Iris L. A. Bodewes, Erika Huijser, Marjan A. Versnel, Haralampos M. Moutsopoulos, Clio P. Mavragani
Summary: This study found that the TT genotype of the rs9514828 SNP in the BAFF gene reduces the likelihood of fatigue development in primary Sjogren's Syndrome patients. Further research is needed to validate these findings.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jinghui Ji, Xiaoyu Zhang, Yitong Ling, Jinhai Tian, Yi Wang, Yunxia Luo, Rong Zhu, Yan Zhou, Tiantian Zhu, Libin Wang, Hong Zhu
Summary: This study explored the expression level, association with disease activity, and clinical significance of hsa_circ_0008301 in the peripheral blood of patients with primary Sjogren's syndrome (pSS). The results showed that hsa_circ_0008301 was significantly upregulated in pSS patients and correlated with disease activity. It may serve as a potential biomarker for the diagnosis and monitoring of pSS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Tzu-Jung Fang, Ruei-Nian Li, Yuan-Zhao Lin, Chia-Hui Lin, Chia-Chun Tseng, Wan-Yu Sung, Tsan-Teng Ou, Cheng-Chin Wu, Jeng-Hsien Yen
Summary: The study examined the relationship between F11R gene polymorphism and SS patients, showing that the -436A/G genotype is associated with susceptibility to SS in HLA-DR2 negative and HLA-DR3 negative individuals. Additionally, F11R mRNA expression was significantly lower in SS patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Qiufeng Xiao, Xunyao Wu, Chuiwen Deng, Lidan Zhao, Linyi Peng, Jiaxin Zhou, Wen Zhang, Yan Zhao, Yunyun Fei
Summary: This study investigates the role of the N6-methyladenosine (m6A) RNA modification in patients with primary Sjogren's syndrome (pSS). The results show that certain m6A elements are dysregulated in peripheral blood mononuclear cells (PBMCs) from pSS patients, suggesting their involvement in disease activity and inflammation. These findings contribute to a better understanding of the pathogenesis of pSS and may have implications for targeted therapies.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Akinsola Oyelakin, Erich Horeth, Eun-Ah Christine Song, Sangwon Min, Monika Che, Brandon Marzullo, Christopher J. Lessard, Astrid Rasmussen, Lida Radfar, R. Hal Scofield, David M. Lewis, Donald U. Stone, Kiely Grundahl, Scott S. De Rossi, Zoya Kurago, A. Darise Farris, Kathy L. Sivils, Satrajit Sinha, Jill M. Kramer, Rose-Anne Romano
Summary: Primary Sjogren's syndrome is a systemic autoimmune disease primarily affecting women, leading to loss of saliva and tears. Currently, there is no effective cure due to limited understanding of disease etiology and pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ning Li, Lei Li, Mengyao Wu, Yusi Li, Jie Yang, Yicheng Wu, Haimin Xu, Danyang Luo, Yiming Gao, Xiaochun Fei, Liting Jiang
Summary: Using transcriptome sequencing and bioinformatics analysis, this study identified 28 upregulated differentially expressed genes in pSS patients, mainly involved in immune-related and infection-related pathways. Morphological features of minor salivary glands changed significantly with pSS disease progression, including lymphocytic infiltrates, acinar atrophy, and nuclear shrinkage. Selected hub genes based on these DEGs were correlated with T follicular helper cells, memory B cells, and M1 macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ruei-Nian Li, Tsan-Teng Ou, Chia-Hui Lin, Yuan-Zhao Lin, Tzu-Jung Fang, Yi-Jing Chen, Chia-Chun Tseng, Wan-Yu Sung, Cheng-Chin Wu, Jeng-Hsien Yen
Summary: This study aims to investigate the associations between NLRP3 gene polymorphisms and rheumatoid arthritis (RA) and primary Sjogren's syndrome (SS) patients. The results showed that the T allele of rs4612666 CT increased the susceptibility to RA disease, and the A allele of rs12079994 G/A polymorphism was associated with significantly higher RF titer in RA patients during diagnosis. The titer of anti-CCP during diagnosis of RA was high in the absence of the C allele of rs10754558 C/G polymorphisms in RA patients. In primary SS, antinuclear antibody and anti-CCP were positively associated with the A allele of rs12079994 G/A polymorphism, and the C allele of rs4612666 C/T was negatively associated with ANA. The results suggest that NLRP3 gene polymorphisms may play a crucial role in the pathogenesis of RA and primary SS.
Article
Immunology
Hong Luo, Xia Zhou
Summary: This study reveals the common pathogenesis of primary Sjogren's syndrome and COVID-19. Cellular components and metabolic pathways play important roles in the development and progression of these two diseases. In addition, we identified several key genes that can serve as preferable diagnostic markers for COVID-19 and primary Sjogren's syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Theodoros Androutsakos, Theodoros A. Voulgaris, Athanasios-Dimitrios Bakasis, Maria-Loukia Koutsompina, Loukas Chatzis, Ourania D. Argyropoulou, Vasilis Pezoulas, Dimitrios I. Fotiadis, George Papatheodoridis, Athanasios G. Tzioufas, Andreas V. Goules
Summary: This study explored the occurrence of liver fibrosis (LF) in primary Sjogren syndrome (pSS) patients in the context of non-alcoholic fatty liver disease (NAFLD). The results showed that pSS patients had a lower prevalence of liver steatosis and significant liver fibrosis compared to the comparators. Advanced LF was significantly associated with older age, higher LS, greater BMI, and disease status, with age being identified as an independent LF risk factor.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yan Liang, Zhiyu Zhang, Jie Li, Wanwan Luo, Tingwang Jiang, Zaixing Yang
Summary: This study found an association between IL-7 and pSS through a single-center study and a systematic scoping review. IL-7 may play a key role in the immunopathology of pSS, and IL-7 and soluble IL-7R may serve as potential biomarkers for monitoring pSS activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yi Han Chen, Xin Yu Wang, Xin Jin, Zi Yang, Jianguang Xu
Summary: Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by dry eyes and dry mouth. B-cell hyperactivity is a key feature of the disease, leading to efforts to optimize B-cell targeted therapy. Monoclonal antibodies like rituximab (RTX) may be initiated in patients with severe, refractory systemic disease, although clinical trial data on RTX efficacy remains controversial.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jessica Tarn, Dennis Lendrem, Michael Barnes, John Casement, Wan-Fai Ng
Summary: This study investigated the polypharmacy and comorbidities in patients with Primary Sjogren's Syndrome (PSS) using data from the UK Primary Sjogren's Syndrome Registry. The results showed differences in comorbidities and medication use among different PSS subgroups. Age and BMI were associated with increased comorbidity and polypharmacy scores. These findings have potential implications for disease management and clinical trial design.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Anna Bara Unnarsdottir, Aniko Lovik, Chloe Fawns-Ritchie, Helga Ask, Kadri Koiv, Kristen Hagen, Maria Didriksen, Lea Arregui Nordahl Christoffersen, Alexander Berg Gardarsson, Andrew McIntosh, Anna K. Kahler, Archie Campbell, Arna Hauksdottir, Christian Erikstrup, Dorte Helenius Mikkelsen, Drew Altschul, Edda Bjork Thordardottir, Emma Maria Frans, Gerd Kvale, Gunnar Tomasson, Hanna Maria Kariis, Harpa Lind Jonsdottir, Harpa Runarsdottir, Ingibjorg Magnusdottir, Jarle Eid, Johanna Jakobsdottir, Kaspar Rene Nielsen, Kathrine Agergard Kaspersen, Lili Milani, Lill-Iren Schou Trogstad, Lu Yi, Mie Topholm Bruun, Patrick F. Sullivan, Per Minor Magnus, Qing Shen, Ragnar Nesvag, Ragnhild E. Brandlistuen, Reedik Magi, Sisse Rye Ostrowski, Solveig Lokhammer, Stian Solem, Ted Reichborn-Kjennerud, Thomas Folkmann Hansen, Thomas Werge, Thor Aspelund, David J. Porteous, Fang Fang, Kelli Lehto, Ole A. Andreassen, Ole Birger Vesterager Pedersen, Stephanie Le Hellard, Unnur A. Valdimarsdottir
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Rheumatology
P. Olsson, F. Ekblad, A. Hassler, M. Bengtsson, G. Warfvinge, T. Mandl, M. Kvarnstrom
Summary: This study investigated the prevalence of impaired sensation after minor salivary gland biopsy (MSGB) in two Swedish centers and its impact on quality of life. The results showed that 21% of the patients reported long-standing impaired sensation after the biopsy, but it had a low impact on everyday life. The complication frequency was lower when the biopsy was performed by a dentist or an oral and maxillofacial surgeon.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Christian Lundtoft, Pascal Pucholt, Myriam Martin, Matteo Bianchi, Emeli Lundstrom, Maija-Leena Eloranta, Johanna K. Sandling, Christopher Sjowall, Andreas Jonsen, Iva Gunnarsson, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Dag Leonard, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Antonella Notarnicola, Helena Andersson, Oyvind Molberg, Louise Pyndt Diederichsen, Jonas Almlof, Ann-Christine Syvanen, Sergey Kozyrev, Kerstin Lindblad-Toh, Bo Nilsson, Anna M. Blom, Ingrid E. Lundberg, Gunnel Nordmark, Lina Marcela Diaz-Gallo, Elisabet Svenungsson, Lars Ronnblom
Summary: Copy number variation of C4A is associated with the autoimmune repertoire in systemic autoimmune diseases, with a low C4A copy number strongly linked to the presence of autoantibodies. These findings have implications for understanding the mechanisms of autoimmune diseases and patient stratification based on genetic profiles.
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
F. Aghakhanian, M. M. Wiley, B. Khatri, K. L. Tessneer, A. Rasmussen, S. J. Bowman, L. Radfar, R. Omdal, M. Wahren-Herlenius, B. M. Warner, T. Witte, R. Jonsson, M. Rischmueller, P. M. Gaffney, J. A. James, L. Ronnblom, R. H. Scofield, X. Mariette, M. Alarcon-Riquelme, W. F. Ng, K. Sivils, G. Nordmark, U. Deshmukh, A. D. Farris, C. Lessard
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
Summary: This study identifies ten novel genetic risk regions associated with Sjogren's disease, implicating genes involved in immune and salivary gland function.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Charlotta Preger, Antonella Notarnicola, Cecilia Hellstrom, Edvard Wigren, Catia Fernandes-Cerqueira, Marika Kvarnstrom, Marie Wahren-Herlenius, Helena Idborg, Ingrid E. Lundberg, Helena Persson, Susanne Graslund, Per-Johan Jakobsson
Summary: This study identified new potential autoantigens among human cytoplasmic aminoacyl tRNA synthetases in IIM patients, even those previously classified as seronegative. These new autoantibodies have high clinical relevance and may provide insights into the pathogenesis of idiopathic inflammatory myopathies.
JOURNAL OF AUTOIMMUNITY
(2023)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam A. Adler, Ilias Alevizos, Juan-Manuel G. Anaya, Lara Aqrawi, Eva Baecklund, Johan Brun, Sara Magnusson Bucher, Maija-Leena B. Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart Glenn, Daniel Hammenfors, Juliana V. Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend A. Johnsen, Malin Jonsson, Marika Kvarnstroem, Jennifer Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke M. Norheim, Oyvind E. Palm, Kathrine Skarstein, Anna Stolarczyk, Kimberly Taylor, Maria J. Teruel, Elke M. Theander, Swamy S. Venuturupalli, Daniel Wallace, Kiely M. Grundahl, Kimberly U. Hefner, Lida Radfar, David T. Lewis, Donald M. Stone, C. Erick A. Kaufman, Michael Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick Gaffney, Lindsey J. Criswell, Roland Jonsson, Per Eriksson, Simon Bowman, Roald Omdal, Lars Roennblom, Blake Warner, Maureen Rischmueller, Torsten E. Witte, A. Darise H. Farris, Xavier Mariette, Marta Alarcon-Riquelme, Caroline L. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy J. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher Lessard
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, Philip G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Marjan A. Versnel, Edward M. Vital
Summary: This study developed evidence-based points to consider for the measurement and reporting of IFN-I assays in clinical research. The study provides recommendations on terminology, assay characteristics, and reporting practices, as well as explores the clinical applications of IFN-I assays in diagnosis and outcome assessments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Laura Andreoli, Cecilia B. Chighizola, Luca Iaccarino, Angela Botta, Maria Gerosa, Veronique Ramoni, Chiara Tani, Bonnie Bermas, Antonio Brucato, Jill Buyon, Irene Cetin, Christina D. Chambers, Megan E. B. Clowse, Nathalie Costedoat-Chalumeau, Maurizio Cutolo, Sara De Carolis, Radboud Dolhain, Elisa M. Fazzi, Frauke Foerger, Ian Giles, Isabell Haase, Munther Khamashta, Roger A. Levy, Pier Luigi Meroni, Marta Mosca, Catherine Nelson-Piercy, Luigi Raio, Jane Salmon, Peter Villiger, Marie Wahren-Herlenius, Marianne Wallenius, Cristina Zanardini, Yehuda Shoenfeld, Angela Tincani
Summary: Autoimmune rheumatic diseases (ARD) pose challenges to reproductive health. Preconception counseling should consider factors such as fertility, disease impact on pregnancy outcomes, disease activity during pregnancy, medication compatibility, and biomarkers predictive of adverse pregnancy outcomes (APO). Diseases like preeclampsia and pregnancy-induced hypertension are more likely to occur in women with ARD. Placental insufficiency can result in restricted fetal growth. Treatment with compatible drugs is essential for maternal and fetal wellbeing. While limited data is available on medication usage during pregnancy, TNF inhibitors are recommended. Non-medical issues like sexual dysfunction and long-term outcomes of children also require attention in this review. Collaborative research and pregnancy registries will contribute to future insights.
AUTOIMMUNITY REVIEWS
(2023)
Review
Rheumatology
Gudny Ella Thorlacius, Albin Bjork, Marie Wahren-Herlenius
Summary: In primary Sjogren syndrome (pSS), chronic inflammation of exocrine glands leads to tissue destruction and sicca symptoms, mainly affecting the mouth and eyes. Fatigue, arthralgia, and myalgia are common, and some patients also experience extraglandular manifestations involving the respiratory, nervous, and vascular systems. The disease primarily affects women, with a female to male ratio of 14 to 1. The genetic and epigenetic studies have provided insights into the dysregulated molecular mechanisms of pSS and could potentially lead to new therapeutic options.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Rheumatology
Agata Burska, Javier Rodriguez-Carrio, Robert Biesen, Willem A. Dik, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, P. G. Conaghan, Marjan Versnel, Ed Vital
Summary: This study systematically reviewed the literature on assay methods for evaluating type I interferon (IFN-I) pathway activation and aimed to harmonize related terminology. Data from 276 papers on 412 methods were extracted and summarized. Consensus terminology was developed to define different aspects of IFN-I research and practice.
Review
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, P. G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Ed Vital, Marjan Versnel
Summary: This article provides a systematic review of assays measuring IFN-I pathway activation and summarizes the potential clinical utility in various rheumatic and musculoskeletal diseases. The results show that IFN-I pathway activation is associated with disease diagnosis, disease activity assessment, prognosis, response to treatment, and assay responsiveness. However, the heterogeneity in techniques and technical conditions are major limitations.
Article
Rheumatology
Joe Scott Berry, Jessica Tarn, John Casement, Pierre-Marie Duret, Lauren Scott, Karl Wood, Svein-Joar Johnsen, Gunnel Nordmark, Valerie Devauchelle-Pensec, Raphaele Seror, Benjamin Fisher, Fransesca Barone, Simon J. Bowman, Michele Bombardieri, Dennis Lendrem, Renaud Felten, Jacques-Eric Gottenberg, Wan-Fai Ng
Summary: Proteomic and network analysis identified distinct pathobiology and potential therapeutic targets for different subtypes of Sjogren's syndrome (SS). Stratification of patients using the Newcastle Sjogren's Stratification Tool (NSST) revealed an association between high levels of serum IL-6 and improvement in fatigue score. These findings provide insights into the underlying mechanisms and treatment strategies of SS subtypes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Meeting Abstract
Rheumatology
Angeles S. Galindo-Feria, Karin Lodin, Begum Horuluoglu, Sepehr Sarrafzadeh-Zargar, Edvard Wigren, Susanne Graslund, Olof Danielsson, Aladdin J. Mohammad, Dag Leonard, Christopher Sjowall, Thomas Husmark, Malin Hemberg, Silva Puksic, Theodoros Lappas, Balsam Hanna, Marie Wahren-Herlenius, Maryam Dastmalchi, Ingrid E. Lundberg
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
