Article
Rheumatology
Raed Alzyoud, Shahad Alansari, Heba Maaitah, Haya AlDossari, Dorota Monies, Sulaiman M. Al-Mayouf
Summary: This study presents clinical and genetic findings of four patients from a single family with refractory psoriatic arthritis and a hemizygous mutation in the FOXP3 gene, expanding the phenotype spectrum of FOXP3 mutations. The report underscores the impact of immune dysregulation on juvenile arthritis.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Theo Wirth, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham
Summary: PsA diagnosis and treatment is often delayed, resulting in joint damage and disability. Research has identified potential biomarkers to improve PsA diagnosis and prognosis, but further studies are needed to evaluate their performance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Eric Toussirot, Irene Gallais-Serezal, Francois Aubin
Summary: Psoriasis and psoriatic arthritis are immune-mediated diseases that affect the skin, joints or both. They involve complex pathophysiological mechanisms and increased inflammation. These conditions are also associated with a higher risk of cardiometabolic diseases, which are linked to systemic inflammation and can impact disease severity and treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Orsolya Tuende Kovacs, Eszter Toth, Oliver Ozohanics, Eszter Soltesz-Katona, Nikolett Marton, Edit Iren Buzas, Laszlo Hunyady, Laszlo Drahos, Gabor Turu, Gyorgy Nagy
Summary: This study investigated the proteomic changes during osteoclast differentiation in healthy donors, RA, and PsA. The results showed increased expression of proteins involved in metabolic activity, secretory function, and cell polarity during differentiation, while immune signaling pathways were downregulated. The expression differences between healthy donors and RA/PsA patients were most noticeable after the final steps of differentiation. The study provides important insights into the pathophysiology of RA and PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hannah A. Blair
Summary: Secukinumab is an effective treatment for PsA across all key domains, with low rates of adverse effects and sustained long-term efficacy. It is a useful alternative to TNFi and other bDMARDs for adult patients with active PsA.
Review
Cell Biology
Lin-Kun Bai, Ya-Zhen Su, Zong-Di Ning, Cheng-Qiang Zhang, Li-Yun Zhang, Gai-Lian Zhang
Summary: This article reviews the preparation, characteristics and research progress of different animal models for Psoriatic Arthritis (PsA). The experimental animals used to study PsA are mainly rodents, including mice and rats. The retrieved animal models were classified into spontaneous or genetic mutation, transgenic and induced animal models based on the different methods of preparing the models. These PsA animal models involve multiple pathogenesis, and have advantages and disadvantages in terms of lesion appearance, success rate in molding, and reproducibility.
INFLAMMATION RESEARCH
(2023)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ana Maria Crespo-Rodriguez, Jesus Sanz Sanz, Dalifer Freites, Zulema Rosales, Lydia Abasolo, Juan Arrazola
Summary: Psoriasis is a common skin disease that can develop into psoriatic arthritis (PsA) in up to 30% of patients, leading to impaired function and reduced quality of life. Early diagnosis and effective treatments are crucial for halting PsA progression. Sensitive imaging techniques such as ultrasound and MRI play an important role in the diagnosis, follow-up, and prognosis of PsA.
INSIGHTS INTO IMAGING
(2021)
Article
Medicine, General & Internal
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Summary: Psoriatic arthritis (PsA) is a complex inflammatory disease related to psoriasis, presenting challenges in diagnosis and treatment. There are no diagnostic criteria or tests available, and disease heterogeneity may be explained by differences in genotype. New targeted therapies have shown promise in improving outcomes for PsA patients.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Medicine, General & Internal
Andrea Cuervo, Raquel Celis, Antonio Julia, Alicia Usategui, Regina Fare, Julio Ramirez, Ana Belen Azuaga, Andres Lorenzo, Raimon Sanmarti, Jose L. Pablos, Juan D. Canete
Summary: The study found that the cellular composition of synovium in undifferentiated arthritis (UA) patients differs from rheumatoid arthritis (RA) and psoriatic arthritis (PsA), with higher cellular infiltrate density in the UA group. Initial expression of the interferon inducible gene MxA may serve as a biomarker for progression to RA, while higher mast cell and fibroblastic density may be associated with PsA progression.
FRONTIERS IN MEDICINE
(2021)