Editorial Material
Hematology
Federico Simonetta
Summary: The study demonstrates that dual blockade of TNF-α and IL-6R provides a significant advantage over single-cytokine blockade in protecting mice from lethal graft-versus-host disease.
Article
Rheumatology
Laure Gossec, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, Tatiana Korotaeva, Frederic Lavie, Wim Noel, Michael T. Nurmohamed, Petros P. Sfikakis, Elke Theander, Josef S. Smolen
Summary: In the real-world treatment of psoriatic arthritis, ustekinumab and TNFi demonstrate comparable overall treatment persistence, effectiveness, and safety.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Dongze Wu, Priscilla Wong, Steven H. M. Lam, Edmund K. Li, Ling Qin, Lai-Shan Tam, Jieruo Gu
Summary: The study found that genetic variants predisposing to higher physiological IL-17 level are associated with decreased risk of PsA, but no causal effect was observed between TNF-alpha, IL-12p70, decreased IL-17 levels, and risk of PsA.
Review
Biochemistry & Molecular Biology
Bong-Woo Lee, Su-Jin Moon
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects individuals with psoriasis, arthritis, and enthesitis. Inflammatory cytokines, such as TNF-α, IL-23, and IL-17, play a crucial role in the onset and progression of PsA by attracting inflammatory cells to the joint tissues and causing cartilage and bone deterioration. Blocking these cytokines has shown significant clinical benefits, and further research is being conducted to explore other potential therapeutic targets for PsA treatment. This review discusses the current understanding of the role of inflammatory cytokines in PsA pathogenesis and the clinical implications of targeting these cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Paolo Gisondi, Francesco Bellinato, Giovanni Targher, Luca Idolazzi, Giampiero Girolomoni
Summary: In patients with moderate-to-severe chronic plaque psoriasis, treatment with bDMARDs may delay or reduce the risk of incident PsA. The annual incidence rate of PsA was significantly lower in the bDMARDs group compared to the phototherapy group. Factors associated with a higher risk of PsA included older age, nail psoriasis, and psoriasis duration over 10 years.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Endocrinology & Metabolism
Chrong-Reen Wang, Hung-Wen Tsai
Summary: Insulin resistance (IR) is a crucial mechanism leading to the development of diabetes mellitus (DM), requiring higher than normal insulin concentrations to maintain euglycemic status. Many human inflammatory disorders, particularly autoimmune-mediated arthritis conditions, have been associated with an increased risk of IR, especially during active disease states. Using biologic agents and small molecule-targeted drugs can reduce IR and improve diabetic hyperglycemia in autoimmune-mediated arthritis.
WORLD JOURNAL OF DIABETES
(2021)
Review
Immunology
Anais Makos, J. H. Kuiper, O. Kehoe, R. Amarasena
Summary: Psoriatic arthritis is a chronic and painful inflammatory immune-mediated disease. This study aimed to identify potential biomarkers for predicting treatment response and guiding biologic drug therapy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Rheumatology
Enrico De Lorenzis, Gerlando Natalello, Dario Bruno, Giacomo Tanti, Maria Rosaria Magurano, Donatella Lucchetti, Clara Di Mario, Barbara Tolusso, Giusy Peluso, Elisa Gremese
Summary: Depressive symptoms in psoriatic arthritis patients are associated with female sex, current smoking, psoriatic nail disease, physical disability, and higher serum IL-6 levels. A cutoff of 2.27 pg/ml for serum IL-6 can predict the presence of depressive symptoms with good accuracy. This suggests a direct role of systemic inflammation in mood modulation in PsA patients.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Isla Morante, Elena Aurrecoechea, Ignacio Villa, Montserrat Santos, Leyre Riancho, Ruben Queiro
Summary: ASAS-HI demonstrates good measurement properties in patients with PsA, showing high convergent and discriminant validity. ASAS-HI items associated with DAPSA active disease are activity limitation and poor sleep quality.
Article
Medicine, General & Internal
Enrico De Lorenzis, Angela Di Giorgio, Gerlando Natalello, Antonio Nesci, Giacomo Tanti, Pietro Rubortone, Donatella Lucchetti, Maria Rosaria Magurano, Clara Di Mario, Barbara Tolusso, Giusy Peluso, Angelo Santoliquido, Elisa Gremese
Summary: This study found a correlation between depressive symptoms and endothelial dysfunction in PsA patients in an exposure-response pattern.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Vincenzo Venerito, Pasquale Stefanizzi, Marco Fornaro, Fabio Cacciapaglia, Silvio Tafuri, Simone Perniola, Florenzo Iannone, Giuseppe Lopalco
Summary: This study investigated the humoral response to BNT162b2 vaccination in patients with PsA on TNFi treatment and compared it with healthy controls. The study found that continuing TNFi treatment did not hinder the immunogenicity of the vaccine.
Article
Rheumatology
Ulf Lindstrom, Daniela Di Giuseppe, Benedicte Delcoigne, Bente Glintborg, Burkhard Moller, Adrian Ciurea, Manuel Pombo-Suarez, Carlos Sanchez-Piedra, Kari Eklund, Heikki Relas, Bjorn Gudbjornsson, Thorvardur Jon Love, Gareth T. Jones, Catalin Codreanu, Ruxandra Ionescu, Lucie Nekvindova, Jakub Zavada, Nuh Atas, Servet Yolbas, Karen Minde Fagerli, Brigitte Michelsen, Ziga Rotar, Matija Tomsic, Florenzo Iannone, Maria Jose Santos, Pedro Avila-Ribeiro, Lykke Midtboll Ornbjerg, Mikkel Ostergaard, Lennart T. H. Jacobsson, Johan Askling, Michael J. Nissen
Summary: This study suggests that in patients with psoriatic arthritis, treatment with csDMARD in combination with TNFi is associated with improved remission rates compared to TNFi monotherapy. Specifically, methotrexate as a csDMARD can increase remission rates for adalimumab and infliximab.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Chenyang Zhao, Bingqian Liu, Yuan Yao, Kevin Yang, Bo Zang, Bin Liu
Summary: The aim of this study was to identify the clinical characteristics and formulate a standardized management strategy for patients with distal extremity swelling with pitting edema in psoriatic arthritis (PsA). The medical records of 167 PsA patients were analyzed, and 16 of them had distal extremity swelling with pitting edema. Female patients with PsA were more likely to be affected, and blood test results showed higher indicators of inflammation in these patients. The onset of pitting edema was associated with disease activity. Lymphoscintigraphy and MRI scans indicated inflammation of the tenosynovial structures as the cause of edema. Treatment with tumor necrosis factor-alpha inhibitor showed improvement in patients with pitting edema.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Rheumatology
Celia A. J. Michielsens, Nathan den Broeder, Frank H. J. van den Hoogen, Elien A. M. Mahler, Steven Teerenstra, Desiree van der Heijde, Lise M. Verhoef, Alfons A. den Broeder
Summary: In patients with PsA and axSpA, a T2T TNFi strategy with tapering attempt is non-inferior to a T2T strategy without tapering in terms of the proportion of patients still in low disease activity (LDA) at 12 months, and results in a substantial reduction of TNFi use.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Hieronymus T. W. Smeele, Esther Roder, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Radboud J. E. M. Dolhain
Summary: This study is the first to show that the use of TNFi during pregnancy is associated with increased birth weight in offspring of women with well-controlled RA. Further research is needed to explore the underlying mechanism of TNF inhibition on birth weight and its long-term consequences for the offspring.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Review
Rheumatology
Ying-Ying Leung, Tatiana V. Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moeller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lindqvist, David Simon, Amara Ezeonyeli, Enrique R. Soriano, Oliver FitzGerald
Summary: The objective of this study was to provide evidence for the efficacy and safety of therapeutic options for the peripheral arthritis domain of PsA for the revised 2021 GRAPPA treatment recommendations. Evidence was derived from new RCTs and recommendations were made for different patient groups based on their treatment history and response. Different classes of therapeutic options were strongly recommended for different patient groups.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Burkhard Moeller
Summary: Among chronic back diseases, axial spondylarthritis (axSpA) has the largest range of specific anti-inflammatory treatments. However, it is often overlooked as just another cause of back pain in the medical field. This article summarizes the recommendations of the Assessment of Ankylosing Spondyloarthritis International Society (ASAS) and discusses the practical aspects of treatment attempts with nonsteroidal anti-inflammatory drugs (NSAID). It also explores the differences in response to treatment with tumor necrosis factor (TNF) inhibitors based on gender and discusses the use of biologics in axSpA treatment. The importance of early diagnosis and consideration of predictive factors in personalized treatment of axSpA is emphasized.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Fabienne Froehlich, Raphael Micheroli, Monika Hebeisen, Seraphina Kissling, Kristina Buerki, Pascale Exer, Rene Braem, Karin Niedermann, Burkhard Moeller, Michael J. Nissen, Diego Kyburz, Michael Andor, Oliver Distler, Almut Scherer, Adrian Ciurea
Summary: This study aimed to investigate the impact of HLA-B27 on TNFi effectiveness in axSpA patients. The results showed that HLA-B27 negative patients had a higher risk of drug discontinuation in TNFi treatment, while male sex and elevated CRP levels were associated with longer drug retention. Therefore, HLA-B27 genotype is an important predictor of treatment effectiveness, while male sex and CRP levels may better describe the variability of response in individual patients.
CLINICAL RHEUMATOLOGY
(2023)
Correction
Rheumatology
Ying-Ying Leung, Tatiana Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lind-Qvist, David Simon, Amara Ezeonyeji, Enrique R. Soriano, Oliver FitzGerald
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Oncology
Cedric Nesti, Konstantin Braeutigam, Marta Benavent, Laura Bernal, Hessa Boharoon, Johan Botling, Antonin Bouroumeau, Iva Brcic, Maximilian Brunner, Guillaume Cadiot, Maria Camara, Emanuel Christ, Thomas Clerici, Ashley K. Clift, Hamish Clouston, Lorenzo Cobianchi, Jaroslaw B. Cwikla, Kosmas Daskalakis, Andrea Frilling, Rocio Garcia-Carbonero, Simona Grozinsky-Glasberg, Jorge Hernando, Valerie Hervieu, Johannes Hofland, Pernille Holmager, Frediano Inzani, Henning Jann, Paula Jimenez-Fonseca, Enes Kacmaz, Daniel Kaemmerer, Gregory Kaltsas, Branislav Klimacek, Ulrich Knigge, Agnieszka Kolasinska-Cwikla, Walter Kolb, Beata Kos-Kudla, Catarina Alisa Kunze, Stefania Landolfi, Stefano La Rosa, Carlos Lopez Lopez, Kerstin Lorenz, Maurice Matter, Peter Mazal, Claudia Mestre-Alagarda, Patricia Morales del Burgo, Els J. M. Nieveen van Dijkum, Kira Oleinikov, Lorenzo A. Orci, Francesco Panzuto, Marianne Pavel, Marine Perrier, Henrik Mikael Reims, Guido Rindi, Anja Rinke, Maria Rinzivillo, Xavier Sagaert, Ilker Satiroglu, Andreas Selberherr, Alexander R. Siebenhuener, Margot E. T. Tesselaar, Michael J. Thalhammer, Espen Thiis-Evensen, Christos Toumpanakis, Timon Vandamme, Jose G. van den Berg, Alessandro Vanoli, Marie-Louise F. van Velthuysen, Chris Verslype, Stephan A. Vorburger, Alessandro Lugli, John Ramage, Marcel Zwahlen, Aurel Perren, Reto M. Kaderli
Summary: This study investigated whether patients with 1-2 cm appendiceal neuroendocrine tumors (NETs) need to undergo right-sided hemicolectomy, and found that right-sided hemicolectomy is not necessary after appendectomy for appendiceal NETs. Furthermore, it was found that regional lymph node metastases of appendiceal NETs are clinically irrelevant and additional postoperative exclusion of metastases and histopathological evaluation of risk factors is not supported. These findings should inform the development of treatment guidelines.
Editorial Material
Rheumatology
Burkhard Moeller, Joachim Grifka
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Immunology
Mirjam Kolev, Adela-Cristina Sarbu, Burkhard Moller, Britta Maurer, Florian Kollert, Nasser Semmo
Summary: This study retrospectively investigated the treatment response of six patients with AIH or PBC, three of whom had concomitant Sjo center dot gren's disease, using the anti-BAFF therapy belimumab. The results showed that belimumab improved disease control in AIH patients and helped reduce side effects from corticosteroids and calcineurin inhibitors. In PBC patients, there was no clear improvement in liver function tests, but a reduction in IgM levels was observed. Patients with concomitant Sjo center dot gren's disease experienced improvements in sicca symptoms and fatigue.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Article
Rheumatology
Raphael Micheroli, Seraphina Kissling, Kristina Buerki, Burkhard Moeller, Axel Finckh, Michael J. Nissen, Pascale Exer, Rene Bram, Diego Kyburz, Andrea Rubbert-Roth, Michael Andor, Xenofon Baraliakos, Manouk de Hooge, Oliver Distler, Almut Scherer, Adrian Ciurea
Summary: This study aimed to investigate whether anaemia independently predicts spinal radiographic progression. The results showed that although anaemia was associated with higher disease activity in axSpA patients, it did not predict spinal radiographic progression.
CLINICAL RHEUMATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Iulia Minciuna, Suchira Gallage, Mathias Heikenwalder, Shira Zelber-Sagi, Jean-Francois Dufour
Summary: NASH, a chronic liver disease that can progress to end-stage liver disease and HCC, can be effectively treated with intermittent fasting, which not only induces weight loss but also reduces inflammation and oxidative stress.
Article
Rheumatology
Louise Linde, Lykke M. Ornbjerg, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Bjorn Gudbjornsson, Thorvardur Jon Love, Dan C. Nordstrom, Timo Yli-Kerttula, Lucie Nekvindova, Jiri Vencovsky, Florenzo Iannone, Alberto Cauli, Anne Gitte Loft, Bente Glintborg, Karin Laas, Ziga Rotar, Matija Tomsic, Gary J. Macfarlane, Burkhard Moller, Marleen van de Sande, Catalin Codreanu, Michael J. Nissen, Merih Birlik, Sukran Erten, Maria J. Santos, Elsa Vieira-Sousa, Merete L. Hetland, Mikkel Ostergaard
Summary: In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission and moderate response at 6 months, as well as drug retention at 12 months were identified, indicating potential generalizability from country to disease level.
Review
Clinical Neurology
Stevan Stojic, Beatrice Minder, Gabriela Boehl, Tania Rivero, Marcel Zwahlen, Armin Gemperli, Marija Glisic
Summary: This study analyzed the methodological quality of spinal cord injury (SCI) research using systematic reviews and meta-analyses (SRMA) methodology. The results showed that SRMA methodology has been widely used in SCI research, but some articles had poor methodological quality and did not fully adhere to methodological and reporting guidelines.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Rheumatology
Burkhard Moller, Godehard A. Scholz, Jennifer Amsler, Adrian Ciurea, Raphael Micheroli, Michael J. Nissen, Eleftherios Papagiannoulis, Christoph Blapp, Almut Scherer, Nikhil Yawalkar
Summary: This study compared the effectiveness of the first biologic DMARD (bDMARD) in patients with low and high joint counts. The results showed that bDMARD had similar drug retention rates in patients with low and high joint counts. Furthermore, bDMARD retention was significantly better when administered with conventional synthetic DMARD co-therapy.
Article
Medicine, General & Internal
Radoslaw Panczak, Claudia Berlin, Marieke Voorpostel, Marcel Zwahlen, Matthias Egger
Summary: Researchers created a new index based on the latest census data in Switzerland and compared it with the old index. The study found that the Swiss-SEP index accurately measures the socioeconomic status of neighborhoods and is important for studying epidemiology and public health in Switzerland.
SWISS MEDICAL WEEKLY
(2023)
Article
Rheumatology
Vjara Popova, Seraphina Kissling, Raphael Micheroli, Rene Braem, Manouk de Hooge, Xenofon Baraliakos, Michael J. J. Nissen, Burkhard Moeller, Pascale Exer, Michael Andor, Oliver Distler, Almut Scherer, Caroline Ospelt, Adrian Ciurea
Summary: This study analyzed the impact of time-varying treatment with TNFi on structural damage progression in different spinal segments (cervical vs. lumbar spine) in r-axSpA. The results showed that TNFi significantly reduced the odds of progression in the cervical spine, but had no significant effect on the lumbar spine.
ARTHRITIS RESEARCH & THERAPY
(2023)
