期刊
YEAR IN DIABETES AND OBESITY
卷 1281, 期 -, 页码 160-177出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12009
关键词
WAT; BAT; obesity; lipodystrophy
资金
- NIH [R01-DK 080746]
- American Heart Association [0830190N]
The two types of adipose tissue in humans, white and brown, have distinct developmental origins and functions. Human white adipose tissue plays a pivotal role in maintaining whole-body energy homeostasis by storing triglycerides when energy is in surplus, releasing free fatty acids as a fuel during energy shortage, and secreting adipokines that are important for regulating lipid and glucose metabolism. The size of white adipose mass needs to be kept at a proper set point. Dramatic expansion of white fat mass causes obesity-now become a global epidemic disease-and increases the risk for the development of many life-threatening diseases. The absence of white adipose tissue or abnormal white adipose tissue redistribution leads to lipodystrophy, a condition often associated with metabolic disorders. Brown adipose tissue is a thermogenic organ whose mass is inversely correlated with body mass index and age. Therapeutic approaches targeting adipose tissue have been proven to be effective in improving obesity-related metabolic disorders, and promising new therapies could be developed in the near future.
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