期刊
TRANSLATIONAL IMMUNOLOGY IN ASIA-OCEANIA
卷 1283, 期 -, 页码 43-49出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12106
关键词
natural helper cells; innate immunity; cytokine; IL-5; helminth
类别
资金
- Japan Society for the Promotion of Science [22229004, 22689013]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23118526]
- PRESTO from the Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [22689013, 25670235, 22229004] Funding Source: KAKEN
Natural helper (NH) cells are a newly identified innate lymphocyte population that responds to a combination of interleukin (IL)-2 and either IL-25 or IL-33 to produce large amounts of T helper cell type 2 (Th2) cytokines. NH cells have been identified in fat-associated lymphoid clusters (FALCs), produce Th2 cytokines constitutively without any stimulation, and support the self-renewal of B1 cells and IgA production by B cells. Large amounts of IL-5 and IL-13 produced upon helminth infection or in response to IL-33 can induce eosinophilia and goblet cell hyperplasia in the lung and intestine; these cytokines, which activate NH cells, play important roles in antihelminth immunity and allergic diseases such as asthma.
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