Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease

Acrolein Inhalation Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production but Does Not Affect Acute Airways Neutrophilia

(2014) D. I. Kasahara et al.   JOURNAL OF IMMUNOLOGY

Everything Prevents Emphysema

(2011) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts

(2011) Giorgia Volpi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteomic profiling of acrolein adducts in human lung epithelial cells

(2011) Page C. Spiess et al.   Journal of Proteomics

Acrolein scavengers: Reactivity, mechanism and impact on health

(2011) Qin Zhu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acrolein - a pulmonary hazard

(2011) Kiflai Bein et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Airway Mucus Function and Dysfunction

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Cigarette Smoke Components Induce Matrix Metalloproteinase-1 in Aortic Endothelial Cells through Inhibition of mTOR Signaling

(2011) Vincent Lemaître et al.   TOXICOLOGICAL SCIENCES

Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Julie Roy et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9

(2010) Shuang Ren et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simvastatin attenuates acrolein-induced mucin production in rats: Involvement of the Ras/extracellular signal-regulated kinase pathway

(2010) Ya-Juan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - Studies in electrophile response element transgenic mice

(2010) Trude Rakel Balstad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway

(2010) Chae E. Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mutagenicity of acrolein and acrolein-induced DNA adducts

(2010) Xing-yu Liu et al.   TOXICOLOGY MECHANISMS AND METHODS

α,β-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases

(2009) Nadia Moretto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production

(2009) Hitesh S. Deshmukh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intermediate Filament Carbonylation During Acute Acrolein Toxicity in A549 Lung Cells: Functional Consequences, Chaperone Redistribution, and Protection by Bisulfite

(2009) Philip C. Burcham et al.   ANTIOXIDANTS & REDOX SIGNALING

Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells

(2009) Julie Roy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Design, Synthesis, and Evaluation of Carnosine Derivatives as Selective and Efficient Sequestering Agents of Cytotoxic Reactive Carbonyl Species

(2009) Giulio Vistoli et al.   ChemMedChem

Effect of N-Acetylcysteine on Air Trapping in COPD

(2009) David Stav et al.   CHEST

Matrix Metalloproteinases in Respiratory Diseases: From Pathogenesis to Potential Clinical Implications

(2009) Smaragda Oikonomidi et al.   CURRENT MEDICINAL CHEMISTRY

p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog

(2009) Dai-Shun Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis

(2009) Tjard Schermer et al.   RESPIRATORY MEDICINE

OralN-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats

(2009) Shan CAI et al.   RESPIROLOGY

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages

(2009) Timothy E. O'Toole et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genome-Wide Transcriptional Responses to Acrolein

(2008) Colin A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages

(2008) Lauren Kent et al.   CYTOKINE

Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation

(2008) David C. Dorman et al.   INHALATION TOXICOLOGY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells

(2008) Charles R. Myers et al.   TOXICOLOGY

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production

(2007) Hitesh S. Deshmukh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of Airway Mucin Gene Expression

(2007) Philip Thai et al.   Annual Review of Physiology