Article
Nutrition & Dietetics
Fang Li, Yanhui Han, Xian Wu, Xiaoqiong Cao, Zili Gao, Yue Sun, Minqi Wang, Hang Xiao
Summary: This study profiles the tissue distribution of RES metabolites after oral administration in mice and uncovers the important role of gut microbial metabolites in the biological activities of RES in vivo.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Paulina Kobylka, Malgorzata Kucinska, Jacek Kujawski, Dawid Lazewski, Marcin Wierzchowski, Marek Murias
Summary: Resveratrol, a plant-derived phytoalexin, has pleiotropic biological activities, particularly anticancer and chemopreventive properties. It interacts with estrogen receptors and functions as a mixed agonist/antagonist. The hydroxyl groups are crucial for its cytotoxic and antioxidative activities. Through experiments and computational simulations, specific analogues of resveratrol were found to act as selective estrogen receptor modulators.
Article
Environmental Sciences
Khang Huynh, Lea Corkidi, Elizabeth Leonard, Cristi Palmer, James Bethke, Nishanth Tharayil
Summary: The dissipation and transformation of cyantraniliprole in snapdragon plants were influenced by application methods and doses, with higher residue found in high-dose foliar spray treatments. The main transformation pathway was intramolecular rearrangements, with unique metabolites identified in different application methods. Photodegradation was also identified as a potential mechanism in foliar application.
Article
Chemistry, Applied
Shengtao Bo, Sui Kiat Chang, Ting Zhou, Hong Zhu, Yueming Jiang, Bao Yang
Summary: This study successfully synthesized two prenylated resveratrol derivatives with good antioxidant activities by overexpressing prenyltransferase and geranyl diphosphate biosynthesis pathway in E. coli.
Article
Agriculture, Multidisciplinary
Xiaoqi Wang, Dongli Li, Yong Cao, Chi-Tang Ho, Qingrong Huang
Summary: The study synthesized possible metabolites of sinensetin and successfully identified five mono-demethylated metabolites in rats. Among them, 4'-demethylsinensetin, 6-demethylsinensetin, and 3'-demethylsinensetin were the most abundant metabolites. Results also indicated that sinensetin may be easily absorbed in the small intestine, as the total amount of Sin with its metabolites showed a significantly higher content in urine compared to feces.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sang Keun Ha, Min Cheol Kang, Seulah Lee, Om Darlami, Dongyun Shin, Inwook Choi, Ki Hyun Kim, Sun Yeou Kim
Summary: A stilbene glycoside with a unique sugar unit was identified through biotransformation, showing regenerative and anti-inflammatory effects similar to resveratrol. The compound was found to be safe and stable, suggesting the biotransformation method as an efficient platform for producing natural glycosides with enhanced safety.
Article
Biochemistry & Molecular Biology
Yina Xiao, Fubo Han, Ik-Soo Lee
Summary: Biotransformation of four bioactive phenolic constituents from licorice by Aspergillus niger led to the isolation of 17 metabolites, with 12 compounds previously undescribed. Compounds 1 and 12 showed significant cytotoxic activities against human cancer cell lines, suggesting their potential as cancer chemopreventive agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hui-Fang Chiu, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang
Summary: Polyphenols, organic chemicals with phenolic units, have diverse biological functions but low bioavailability and stability, making them less bioactive. Factors like gut microbiota, chemical structure, and interactions with other nutrients may affect polyphenols' efficiency and metabolism. Polyphenols and their metabolites show protective effects against various gastrointestinal disorders, but more clinical trials are needed to confirm their gastroprotective activity.
Article
Engineering, Environmental
Siyao Shao, Sufen Zhang, Zhiyang Yu, Qingfu Ye
Summary: This study demonstrates the accumulation and biotransformation of vanisulfane and its metabolites in laying hens, with transfer to eggs. The identification of eight metabolites associated with phase I and phase II metabolism provides insights into the active biotransformation of vanisulfane in vivo. Understanding the fate of vanisulfane in animals is important for evaluating the risk of food derived from animals exposed to pesticides.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agriculture, Multidisciplinary
Xiaoqi Wang, Dongli Li, Yong Cao, Chi-Tang Ho, Qingrong Huang
Summary: The research found that 5-OH Sin is mostly accumulated in the large intestine, indicating poor absorption in the small intestine. In addition, the C-3' position of 5-OH Sin is more susceptible to demethylation in systemic circulation. Furthermore, methylation transformation of 5-OH Sin and its metabolites was also observed, suggesting bidirectional biotransformation between 5-OH Sin and its parent compound, Sin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ning-Ning Zhang, Zheng-Meng Jiang, Shang -Zhen Li, Xing Yang, E-Hu Liu
Summary: Growing evidence suggests that the status of gut microbiota affects human health, and imbalance of microbiota can lead to various disorders. Natural products are gaining attention due to their therapeutic effects and fewer side effects. Recent studies support that many natural products' activities depend on gut microbiota, while gut microbiota is also modulated by natural products.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Peter A. Gilhooly-Finn, Ian E. Jacobs, Olivier Bardagot, Yasser Zaffar, Antoine Lemaire, Shubhradip Guchait, Lu Zhang, Mark Freeley, William Neal, Fanny Richard, Matteo Palma, Natalie Banerji, Henning Sirringhaus, Martin Brinkmann, Christian B. Nielsen
Summary: This study investigates the electrical and thermoelectric properties of a series of polythiophenes with varying side chain density. It is found that a lower side chain density leads to lower order in the thin films, but doping significantly improves the electrical conductivity. However, for aligned films, lower side chain density results in lower conductivity and Seebeck coefficient.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Organic
Pauline Menelle, Jerome Quintin, Kevin Cottet, Yann Fromentin, Joelle Dupont, Marie-Christine Lallemand, Didier Buisson
Summary: The study successfully identified active microorganisms for the biotransformation of guttiferone A and C from endophytic fungi of Symphonia globulifera. Among the isolates obtained, three were found to be active and were identified as Bipolaris cactivora. The biotransformation products were two regioisomers of oxy-guttiferones, with a ratio similar to that seen in the plant itself.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Immunology
Sujuan Ding, Hongmei Jiang, Jun Fang, Gang Liu
Summary: The study found that resveratrol can reduce inflammation-induced damage to the intestines and liver by lipid polysaccharides, decrease inflammatory factors in the liver, affect serum metabolic profiles, regulate intestinal microorganisms, and has the potential to prevent inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ying Ma, Dongliang Li, Wenfeng Liu, Xiaoxiao Liu, Yingqi Xu, Xinrui Zhong, Fengnan Zhi, Xueling Jia, Yanan Jiang, Yuhua Fan
Summary: The study found that Resveratrol can partially exert a protective effect against atherosclerosis by modulating liver metabolism, alleviating atherosclerosis induced by a high-fat diet. The results also suggest that Resveratrol's impact on specific metabolic pathways may be beneficial in the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Paul Oster, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, Marine M. Leblond, Meriem Messaoudene, Elisavet Machremi, Emeric Limagne, Francois Ghiringhelli, Bertrand Routy, Gregory Verdeil, Dominique Velin
Summary: This study revealed that Helicobacter pylori infection may reduce the efficacy of cancer immunotherapies, as demonstrated in mouse models and human clinical studies.
Article
Oncology
Emeric Limagne, Lisa Nuttin, Marion Thibaudin, Elise Jacquin, Romain Aucagne, Marjorie Bon, Solene Revy, Robby Barnestein, Elise Ballot, Caroline Truntzer, Valentin Derangere, Jean-David Fumet, Charlene Latour, Cedric Rebe, Pierre-Simon Bellaye, Coureche-Guillaume Kaderbhai, Aodrenn Spill, Bertrand Collin, Mary B. Callanan, Aurelie Lagrange, Laure Favier, Bruno Coudert, Laurent Arnould, Sylvain Ladoire, Bertrand Routy, Philippe Joubert, Francois Ghiringhelli
Summary: Chemotherapy combined with MEK inhibitor enhances the sensitivity of lung cancer cells to immune checkpoint inhibitors by inducing CXCL10 expression and CD8(+) T cell recruitment. The study also highlights the role of TLR9- and OPTN-dependent mitophagy in enhancing the efficacy of chemoimmunotherapy.
Article
Oncology
Jean marc Phelip, Jerome Desrame, Julien Edeline, Emilie Barbier, Eric Terrebonne, Pierre Michel, Herve Perrier, Laetitia Dahan, Vincent Bourgeois, Faiza Khemissa Akouz, Emilie Soularue, Valerie Lebrun Ly, Yann Molin, Thierry Lecomte, Francois Ghiringhelli, Romain Coriat, Samy Louafi, Cindy Neuzillet, Sylvain Manfredi, David Malka
Summary: This study compared triplet chemotherapy with doublet chemotherapy in advanced biliary tract cancer treatment, with the results showing triplet chemotherapy did not meet the primary study endpoint. Doublet chemotherapy remains the first-line standard in advanced BTC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Meriem Messaoudene, Reilly Pidgeon, Corentin Richard, Mayra Ponce, Khoudia Diop, Myriam Benlaifaoui, Alexis Nolin-Lapalme, Florent Cauchois, Julie Malo, Wiam Belkaid, Stephane Isnard, Yves Fradet, Lharbi Dridi, Dominique Velin, Paul Oster, Didier Raoult, Francois Ghiringhelli, Romain Boidot, Sandy Chevrier, David T. Kysela, Yves Brun, Emilia Liana Falcone, Genevieve Pilon, Florian Plaza Onate, Oscar Gitton-Quent, Emmanuelle Le Chatelier, Sylvere Durand, Guido Kroemer, Arielle Elkrief, Andre Marette, Bastien Castagner, Bertrand Routy
Summary: The study demonstrates that oral supplementation with polyphenol-rich berry camu-camu alters gut microbial composition in mice, leading to antitumor activity and enhanced anti-PD-1 response. The active compound castalagin enriches for specific bacteria and induces metabolic changes to support immunotherapy efficacy.
Editorial Material
Cell Biology
Emeric Limagne, Francois Ghiringhelli
Summary: This study reveals the role of MAPK in chemo-immunotherapy and suggests that inhibition of MAPK pathway could enhance cancer cell mitophagy and improve the efficacy of immunotherapy.
Article
Oncology
Marion Thibaudin, Emeric Limagne, Lea Hampe, Elise Ballot, Caroline Truntzer, Francois Ghiringhelli
Summary: The combination of atezolizumab and tiragolumab shows potential in reactivating the immune response in microsatellite stable colorectal cancers (MSS-CRC), especially in patients with higher baseline cell frequency and CD96 expression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Julie Niogret, Valentin Derangere, Corentin Richard, Lisa Nuttin, Francois Ghiringhelli, Laure Favier, Leila Bengrine Lefevre, Anthony Bergeron, Laurent Arnould, Romain Boidot
Summary: Low-grade serous carcinoma is a less common subtype of serous carcinoma with better prognosis but poor response to chemotherapy. This study aims to evaluate the clinical benefit of MEK inhibitors in the management of advanced-stage low-grade serous carcinoma with KRAS or NRAS mutation. The results showed that MEK inhibitors, in combination with anti-EGFR antibody, provided disease stabilization in patients with RAS-mutated low-grade serous carcinoma. RB1 loss-of-function mutation may be a mechanism of resistance to MEK inhibitors in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Valerie Jooste, Leila Bengrine-Lefevre, Sylvain Manfredi, Valerie Quipourt, Pascale Grosclaude, Olivier Facy, Come Lepage, Francois Ghiringhelli, Anne-Marie Bouvier
Summary: Real-world data on the management and outcomes of pancreatic cancer showed that only half of elderly patients aged 75-84 with a surgically resectable tumor actually underwent resection, and a significant percentage of patients aged >= 85 refused chemotherapy, highlighting the need for expanded geriatric assessments.
Review
Cell Biology
Laura Kalfeist, Loick Galland, Fanny Ledys, Francois Ghiringhelli, Emeric Limagne, Sylvain Ladoire
Summary: Glucocorticoids are widely prescribed drugs in cancer patients due to their anti-inflammatory, anti-oedema, and anti-allergy properties. They are used in various clinical situations in oncology, including managing cancer-related symptoms and preventing or treating side effects or immune-related adverse events of anti-cancer therapies. Moreover, glucocorticoids have been found to affect immune response and tumor efficacy.
Review
Cell Biology
Nicolas Roussot, Francois Ghiringhelli, Cedric Rebe
Summary: The success of anticancer treatments depends on the ability of dying cancer cells under chemotherapy or physical stress to activate immune cells and stimulate an antitumor response. This can be achieved through the release of danger-associated molecular patterns (DAMPs) and the recruitment of CD8 T cells. However, the effectiveness of immune checkpoint blockers in reversing T-cell exhaustion is dependent on the recruitment of CD8 T cells within the tumor. Chemokines play a crucial role in CD8 T-cell recruitment. This review aims to explore the role of chemokines released during immunogenic cell death (ICD) in CD8 T-cell recruitment and antitumor response, as well as their potential clinical applications.
Review
Oncology
Loick Galland, Nicolas Roussot, Isabelle Desmoulins, Didier Mayeur, Coureche Kaderbhai, Silvia Ilie, Audrey Hennequin, Manon Reda, Juliette Albuisson, Laurent Arnould, Romain Boidot, Caroline Truntzer, Francois Ghiringhelli, Sylvain Ladoire
Summary: Breast cancer is the most common cancer in the world, and advancements in technology allow for the identification of specific molecular alterations in tumor cells, leading to new treatment options. This review summarizes the clinical utility of genomic tests in evaluating homologous recombination repair deficiency for breast cancer treatment decisions.
Article
Oncology
Nesrine Mabrouk, Cindy Racoeur, Jingxuan Shan, Aurelie Massot, Silvia Ghione, Malorie Privat, Lucile Dondaine, Elise Ballot, Caroline Truntzer, Romain Boidot, Francois Hermetet, Valentin Derangere, Melanie Bruchard, Frederique Vegran, Lotfi Chouchane, Francois Ghiringhelli, Ali Bettaieb, Catherine Paul
Summary: Our study aimed to test the beneficial effect of the nitric oxide donor glyceryltrinitrate (GTN) in combination with the chemotherapy drug doxorubicin in the treatment of triple-negative breast cancer (TNBC). Using a mouse model of TNBC, we found that the combination of the two drugs induced greater tumor regression compared to monotherapies, which was correlated with stronger activation of the immune system and a decrease in immunosuppressive immune cells. These findings suggest a new therapeutic perspective for TNBC treatment.
Article
Cell Biology
Aicha Sassi, Maxime Fredon, Alexia K. Cotte, Camille Fuselier, Christophe Schneider, Laurent Martiny, David Monchaud, Leila Chekir-Ghedira, Virginie Aires, Dominique Delmas
Summary: Despite progress in treatments, melanoma incidence and mortality have increased. Chrysin, a natural polyphenol, shows potential as a therapeutic strategy due to its modulation of tumorigenesis and resistance mechanisms. This study reveals a link between chrysin-induced antitumoral effects, DNA damage pathway activation, and reduced angiogenesis in melanoma cells. The disruption of key protein actors in tumor growth by chrysin suggests its potential as a new therapeutic strategy in melanoma treatment.
Article
Imaging Science & Photographic Technology
Julien Odet, Julie Pellegrinelli, Olivier Varbedian, Caroline Truntzer, Marco Midulla, Francois Ghiringhelli, David Orry
Summary: This study aimed to identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). The size of the lesions and the nearby vessel were found to be significant risk factors for LR.
JOURNAL OF IMAGING
(2023)
