Article
Biochemistry & Molecular Biology
Evan Paul Tracy, William Hughes, Jason E. Beare, Gabrielle Rowe, Andreas Beyer, Amanda Jo LeBlanc
Summary: The vasculature responds to tissue respiratory needs by modulating luminal diameter, but age-related reduction in blood flow contributes to and exacerbates pathological processes. Current research focuses on mechanisms behind aging-mediated vascular dysfunction and therapeutic strategies to restore youthful vascular responsiveness, aiming at symptom management, tissue damage reversal, and prevention of aging-induced vascular damage and dysfunction. Antioxidative therapeutic strategies are being developed to restore mitochondrial redox homeostasis and subsequently vascular function.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Nutrition & Dietetics
Gaia Gherardi, Giovanni Corbioli, Filippo Ruzza, Rosario Rizzuto
Summary: Mitochondria play crucial roles in maintaining cellular homeostasis, regulating energy metabolism, determining cell fate, and serving as intracellular signaling hubs. Mitochondrial deterioration is a critical feature of the aging process, making treatments that improve and sustain mitochondrial functionality potential candidates to counteract age-related mitochondrial dysfunctions.
Article
Behavioral Sciences
Gulcin Gacar, Semil Selcen Gocmez, Zehra Seda Halbutogullari, Kamil Can Kilic, Aysenur Kaya, Yusufhan Yazir, Tijen Utkan
Summary: This study investigated the effects of resveratrol on vascular function in a rat model of chronic psychological stress and explored its possible mechanisms. The results showed that resveratrol improved depressive-like behavior, ameliorated vascular dysfunction, and reduced stress-induced inflammation. Therefore, resveratrol may be a therapeutic option with vasculoprotective effects in depression induced by chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kuo-Cheng Lan, Pei-Jin Peng, Ting-Yu Chang, Shing-Hwa Liu
Summary: This study aimed to explore the role of AGEs in renal function decline in the elderly and the protective effect of resveratrol, and to compare it with aminoguanidine as an AGEs inhibitor. The results showed that the administration of D-galactose significantly increased serum levels of AGEs and renal function markers, which could be reversed by treatment with aminoguanidine or resveratrol. These findings suggest that resveratrol could alleviate AGEs-related renal dysfunction through the improvement of renal cellular senescence, apoptosis, and fibrosis.
Article
Chemistry, Medicinal
Valeria Conti, Joseph Iharinjaka Randriamboavonjy, Herintsoa Rafatro, Valentina Manzo, Jessica Dal Col, Amelia Filippelli, Graziamaria Corbi, Angela Tesse
Summary: Vascular aging is associated with various factors such as reduced NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. This study investigated the effect of MOI on vascular improvement in middle-aged rats and its involvement of SIRT1. The results showed that MOI treatment enhanced SIRT1 expression and activity, reduced oxidative stress, and reversed FOXO1 expression in the aorta, suggesting its protective role against cardiovascular dysfunction due to aging.
Article
Biochemistry & Molecular Biology
Ana Asenjo-Bueno, Elena Alcalde-Estevez, Mariam El Assar, Gemma Olmos, Patricia Plaza, Patricia Sosa, Patricia Martinez-Miguel, Maria Piedad Ruiz-Torres, Susana Lopez-Ongil
Summary: Aging impairs vascular function, potentially due to hyperphosphatemia-induced oxidative stress. Old mice showed an imbalance in oxidant/antioxidant levels in their aortas, but a low-phosphate diet improved vascular function and restored the balance.
Article
Physiology
Lawrence E. Greiten, Bin Zhang, Carolyn M. Roos, Michael Hagler, Fritz-Patrick Jahns, Jordan D. Miller
Summary: The study demonstrates the crucial role of SIRT6 in regulating conduit vessel vasomotor function, with reductions in SIRT6 leading to endothelial dysfunction. Inhibition of NAD(P)H oxidase expression and activation can improve endothelial function in SIRT6 haploinsufficient mice.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Md Jamal Uddin, Mithila Farjana, Akhi Moni, Khandkar Shaharina Hossain, Md Abdul Hannan, Hunjoo Ha
Summary: As we age, our kidneys become more susceptible to damage, making natural compound resveratrol an attractive potential anti-aging agent. Researchers are actively investigating the mechanisms by which resveratrol delays kidney aging and minimizes side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
JaeKyoung Ahn, Hankyeol Jeong, Bo-Gyeong Seo, Ki-Soo Park, Cheol Hwangbo, Han-Gyul Kim, Jin-Sin Koh, Jaemin Kim
Summary: This study conducted a genome-wide association study (GWAS) in a Korean population to identify germline genetic variants associated with vascular aging. The study revealed 60 genes related to angiogenesis, inflammatory response in blood vessels, and cardiovascular diseases, and found an enrichment of putative protective alleles in an independent population with decelerated vascular aging phenotypes. Additionally, the study showed differential mRNA expression levels of putative causal genes in aging human primary endothelial cells. These findings shed light on the contribution of genetic variants to the etiology of vascular aging and the potential link between vascular aging and cardiovascular traits.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yanhan Hou, Shasha Li, Hongyan Zhu, Mengxue Qiao, Xiaowen Sun, Guorong Li
Summary: This study systematically investigated the development and degeneration of the thymus and kidney in Nothobranchius guentheri fish and the effects of resveratrol on aging. The results showed that the thymus and kidney underwent distinct developmental changes at different stages of fish growth, and degeneration of the thymus and kidney occurred with age. Feeding resveratrol ameliorated the aging-related changes in the kidney and thymus and reduced inflammation. This study provides important insights into the development of immune organs and the anti-aging effects of resveratrol in short-lived fish.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fanglin Niu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Hua Guan, Yang Li, Yan Zhang, Yirong Li, Junle Yang, Lu Qian, Wenzhen Shi, Xiaobin Fan, Jinli Li, Lele Shi, Yi Yu, Yuyan Xiong
Summary: This study found that abnormal hyperexpression of GIGYF2 was observed in senescent human endothelial cells (ECs) and the aortas of old mice. Silencing GIGYF2 can suppress the senescence and dysfunction of ECs. On the contrary, overexpression of GIGYF2 promotes senescence, dysfunction, and activation of the mTORC1-SK61 pathway in non-senescent cells. The study also revealed that GIGYF2 acts as an RNA binding protein (RBP) to enhance STAU1 mRNA stability and that LAMTOR4 expression is upregulated by the binding of STAU1 protein to its intron region. The disruption of the GIGYF2-STAU1-mTORC1 signaling cascade may be a promising therapeutic approach against vascular aging and aging-related cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Anna-Maria Louka, Dimitrios Sagris, George Ntaios
Summary: Stroke is a devastating manifestation of cardiovascular disease, with aging, arterial hypertension, and atherosclerosis identified as independent risk factors. Recent studies have shown the influence of the immune system on atherosclerosis, vascular stiffness, and aging, contributing to various stroke-related issues.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Physiology
Camilla Martignon, Anna Pedrinolla, Fabio Giuseppe Laginestra, Gaia Giuriato, Paolo Saggin, Michele Tinazzi, Federico Schena, Massimo Venturelli
Summary: Previous studies have shown that aging, neurodegeneration, and physical activity level are associated with changes in blood vessels. However, the impact of Parkinson's disease (PD) on the overall vascular function and muscle circulation is still unclear. This study examined the hyperemic response in the femoral artery during a passive leg movement test in PD patients, comparing them with healthy elderly individuals and young healthy individuals. The results suggest that peripheral circulation and vascular function are not reduced in physically active PD patients, indicating that these vascular changes may resemble the normal aging process rather than being affected by the disease.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Geriatrics & Gerontology
Emily W. Waigi, R. Clinton Webb, Melissa A. Moss, Mark J. Uline, Cameron G. McCarthy, Camilla Ferreira Wenceslau
Summary: Dementia is a group of symptoms that affect a person's ability to perform everyday activities, including memory difficulties, language problems, and thinking skill impairments. Alzheimer's disease is the most common form of dementia and cardiovascular diseases are a major cause of disability and premature death. There is an association between AD and CVD, and understanding the mechanistic pathways of this association is an important area of research.
Review
Biochemistry & Molecular Biology
Bowen Zhao, Lijia Zhu, Meng Ye, Xiaotong Lou, Qianxue Mou, Yuanyuan Hu, Hong Zhang, Yin Zhao
Summary: Vascular aging is a crucial factor in the development of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are common causes of irreversible blindness, but effective treatments are still lacking. This review summarizes recent discoveries on the role of oxidative stress and epigenetics in microvascular degeneration, providing potential therapeutic targets for DR and AMD.
MOLECULAR MEDICINE
(2023)
