Article
Cell Biology
Shun Yan, Yin Peng, Jin Lu, Saima Shakil, Yang Shi, David K. Crossman, Walter H. Johnson, Shanrun Liu, Donald G. Rokosh, Joy Lincoln, Qin Wang, Kai Jiao
Summary: miRNA-mediated gene regulation is found to differentially regulate the development of mitral and tricuspid valves, explaining the non-association of mitral and tricuspid dysplasia observed clinically.
JOURNAL OF CELL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Halawa, Najma Latif, Yuan-Tsan Tseng, Ayman M. Ibrahim, Adrian H. Chester, Ahmed Moustafa, Yasmine Aguib, Magdi H. Yacoub
Summary: Cardiac valves - highly complex structures that interact with cells, extracellular matrix, and hemodynamic environment - are tightly regulated by various mechanisms including epigenetic factors. This study analyzed the differential methylation profiles of non-diseased human aortic and mitral valve tissue, revealing candidate genes and signaling pathways associated with valve physiology and pathology. These findings contribute to our understanding of valve biology, tissue engineering approaches, and drug target discovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maria Casanova-Acebes, Erica Dalla, Andrew M. Leader, Jessica LeBerichel, Jovan Nikolic, Blanca M. Morales, Markus Brown, Christie Chang, Leanna Troncoso, Steven T. Chen, Ana Sastre-Perona, Matthew D. Park, Alexandra Tabachnikova, Maxime Dhainaut, Pauline Hamon, Barbara Maier, Catherine M. Sawai, Esperanza Agullo-Pascual, Markus Schober, Brian D. Brown, Boris Reizis, Thomas Marron, Ephraim Kenigsberg, Christine Moussion, Philippe Benaroch, Julio A. Aguirre-Ghiso, Miriam Merad
Summary: Macrophages play a crucial role in shaping the tumor microenvironment and tumor immunity, with tissue-resident macrophages identified as key contributors to early lung cancer progression. Targeting tissue-resident macrophages may offer new possibilities for prevention and treatment of early lung cancer lesions.
Article
Multidisciplinary Sciences
Shinichiro Takashima, Soichiro Usui, Oto Inoue, Chiaki Goten, Kosei Yamaguchi, Yusuke Takeda, Shihe Cui, Yoshio Sakai, Kenshi Hayashi, Kenji Sakata, Masa-aki Kawashiri, Masayuki Takamura
Summary: The study found that the adipose tissue-derived stromal vascular fraction (Ad-SVF) from adult mice can be transdifferentiated into beating cardiomyocyte-like cells through a simple culture method. These beating cardiomyocytes exhibit characteristics of cardiomyocytes and show synchronized oscillation of intracellular calcium concentration on day 28 of culture. The research identified key transcription factors, such as myocyte-specific enhancer 2c (Mef2c), that play a role in this transdifferentiation process.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Nasrin Zare Zavieyh Jaghi
Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biophysics
Jinsheng Li, Wenqing Hou, Yali Yang, Qing Deng, Hong Fu, Yiran Yin, Ke Duan, Bo Feng, Tailin Guo, Jie Weng
Summary: In this study, the effect of micro/nano-topography (MNT) on Periostin (Postn) was investigated, revealing a new signaling pathway. TiO2 nanotubes were found to promote osteoblast differentiation by up-regulating Postn expression, and Postn activated the FAK signal pathway and β-catenin translocation by interacting with integrin αV.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Cell Biology
Yuan Li, Zhenning Wang, Jaffer A. Ajani, Shumei Song
Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Alessio Paolini, Federica Fontana, Van-Cuong Pham, Claudia Jasmin Roedel, Salim Abdelilah-Seyfried
Summary: In the zebrafish embryo, blood flow generates fluid shear stress on endocardial cells, activating Notch and Klf2 signaling pathways crucial for atrioventricular valvulogenesis. Lateral inhibition mediated by Notch selects Delta-like-4-positive endocardial cells to ingress into the cardiac jelly and form an abluminal cell population. Wnt9a signaling cascade, activated by blood flow through Erk5Klf2-Wnt9a pathway, drives Delta-like-4-positive cells towards either luminal or abluminal fates, ultimately sculpting cardiac valve leaflets.
Review
Medicine, Research & Experimental
Ghader Babaei, Mehdi Asghari Vostakolaei, Masoumeh Rajabi Bazl, Shiva Gholizadeh-Ghaleh Aziz, Elham Gholipour, Kazem Nejati-Koshki
Summary: Exosomes play fundamental roles in cell-cell communications and are associated with cancer metastasis by modulating EMT and CSCs.
Article
Oncology
Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uckun, Marc Vigny, Wancun Zhang, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Jikui Guan
Summary: The research reveals that ALK and RET play crucial roles in regulating cell signaling and phenotype transition in neuroblastoma. ALK is able to modulate the phosphorylation and transcription levels of RET signaling, while RET knockout results in a striking epithelial-to-mesenchymal transition phenotype in the cells.
Review
Cell Biology
Tammy M. Holm, Syn Yeo, Kevin M. Turner, Jun-Lin Guan
Summary: Autophagy plays a crucial role in thyroid cancer, promoting tumor cell survival and metastasis, while also inhibiting tumor development by maintaining genomic stability. Autophagy inhibitors may enhance the effectiveness of thyroid cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Kevin Nee, Dennis Ma, Quy H. Nguyen, Maren Pein, Nicholas Pervolarakis, Jacob Insua-Rodriguez, Yanwen Gong, Grace Hernandez, Hamad Alshetaiwi, Justice Williams, Maha Rauf, Kushal Rajiv Dave, Keerti Boyapati, Aliza Hasnain, Christian Calderon, Anush Markaryan, Robert Edwards, Erin Lin, Ritesh Parajuli, Peijie Zhou, Qing Nie, Sundus Shalabi, Mark A. LaBarge, Kai Kessenbrock
Summary: Premalignant stromal cells from women with germline BRCA1 mutations have increased expression of secreted factors regulating epithelial homeostasis, promoting premalignant epithelial changes and increased breast cancer risk. The stromal niche in BRCA1-driven tumor initiation promotes epithelial proliferation and mutant BRCA1-driven tumorigenesis through paracrine signals, such as matrix metalloproteinase 3 (MMP3), produced by pre-cancer-associated fibroblasts (pre-CAFs). This study highlights the importance of precancerous stroma in BRCA1(+/mut) in elevating breast cancer risk.
Article
Biochemical Research Methods
Julia Vallverdu, Raquel A. Martinez Garcia de la Torre, Inge Mannaerts, Stefaan Verhulst, Ayla Smout, Mar Coll, Silvia Arino, Teresa Rubio-Tomas, Beatriz Aguilar-Bravo, Celia Martinez-Sanchez, Delia Blaya, Catherine M. Verfaillie, Leo A. van Grunsven, Pau Sancho-Bru
Summary: Human iPSCs are differentiated into HSCs with growth factors for in vitro modeling. The protocol yields iPSC-HSCs with phenotypic and functional characteristics of primary HSCs, suitable for high-throughput in vitro studies. Coculturing iPSC-HSCs with hepatocytes allows for the formation of 3D hepatic spheroids, enabling modeling and drug screening studies.
Article
Oncology
Jamie L. Null, Dae Joong Kim, V. James McCann, Patcharin Pramoonjago, Jay W. Fox, Jianhao Zeng, Pankaj Kumar, Lincy Edatt, Chad Pecot, Andrew C. Dudley
Summary: Cancer cell dissemination to sentinel lymph nodes is associated with poor patient outcomes, particularly in breast cancer. The process by which cancer cells egress from the primary tumor upon interfacing with the lymphatic vasculature is complex and driven by dynamic interactions between cancer cells and stromal cells, includ-ing cancer-associated fibroblasts (CAF).
Article
Biochemistry & Molecular Biology
Xiuqun Wei, Shujuan Guo, Qian Liu, Li Liu, Fangjun Huo, Yafei Wu, Weidong Tian
Summary: Dental follicle stem cells (DFSCs) promote periodontal regeneration in an inflammatory microenvironment by expressing periostin and improving the immune microenvironment through macrophage recruitment and reprogramming. Silencing periostin attenuates the effects of DFSCs in promoting periodontal regeneration and regulating macrophages. Recombinant human periostin (rhPeriostin) can directly promote macrophage reprogramming and show potential for promoting periodontal regeneration when loaded in a collagen matrix.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Angus C. Grey, Andrew K. Gelasco, Jarren Section, Ricardo A. Moreno-Rodriguez, Edward L. Krug, Kevin L. Schey
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2010)
Article
Biology
Adrian Neagu, Vladimir Mironov, Ioan Kosztin, Bogdan Barz, Monica Neagu, Ricardo A. Moreno-Rodriguez, Roger R. Markwald, Gabor Forgacs
Article
Biochemistry & Molecular Biology
Bingruo Wu, Zheng Zhang, Wendy Lui, Xiangjian Chen, Yidong Wang, Alyssa A. Chamberlain, Ricardo A. Moreno-Rodriguez, Roger R. Markwald, Brian P. O'Rourke, David J. Sharp, Deyou Zheng, Jack Lenz, H. Scott Baldwin, Ching-Pin Chang, Bin Zhou
Article
Cardiac & Cardiovascular Systems
Paige Snider, Robert B. Hinton, Ricardo A. Moreno-Rodriguez, Jian Wang, Rhonda Rogers, Andrew Lindsley, Fang Li, David A. Ingram, Donald Menick, Loren Field, Anthony B. Firulli, Jeffery D. Molkentin, Roger Markwald, Simon J. Conway
CIRCULATION RESEARCH
(2008)
Article
Cell Biology
Vladimir Kasyanov, Ricardo A. Moreno-Rodriguez, Martins Kalejs, Iveta Ozolanta, Peteris Stradins, Xuejun Wen, Hai Yao, Vladimir Mironov
CONNECTIVE TISSUE RESEARCH
(2013)
Article
Developmental Biology
Russell A. Norris, Ricardo A. Moreno-Rodriguez, Yukiko Sugi, Stanley Hoffman, Jenny Amos, Mary M. Hart, Jay D. Potts, Richard L. Goodwin, Roger R. Markwald
DEVELOPMENTAL BIOLOGY
(2008)
Article
Developmental Biology
Cheng Cui, Tracey J. Cheuvront, Rusty D. Lansford, Ricardo A. Moreno-Rodriguez, Thomas M. Schultheiss, Brenda J. Rongish
DEVELOPMENTAL BIOLOGY
(2009)
Article
Anatomy & Morphology
R. A. Norris, R. Moreno-Rodriguez, A. Wessels, J. Merot, P. Bruneval, A. H. Chester, M. H. Yacoub, A. Hagege, S. A. Slaugenhaupt, E. Aikawa, J. J. Schott, A. Lardeux, B. S. Harris, L. K. Williams, A. Richards, R. A. Levine, R. R. Markwald
DEVELOPMENTAL DYNAMICS
(2010)
Article
Biochemistry & Molecular Biology
Shibnath Ghatak, Suniti Misra, Russell A. Norris, Ricardo A. Moreno-Rodriguez, Stanley Hoffman, Robert A. Levine, Vincent C. Hascall, Roger R. Markwald
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Cell Biology
Tatiana V. Tkatchenko, Ricardo A. Moreno-Rodriguez, Simon J. Conway, Jeffery D. Molkentin, Roger R. Markwald, Andrei V. Tkatchenko
PHYSIOLOGICAL GENOMICS
(2009)
Article
Cell Biology
Russell A. Norris, Ricardo Moreno-Rodriguez, Stanley Hoffman, Roger R. Markwald
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2009)
Article
Biochemistry & Molecular Biology
Shibnath Ghatak, Suniti Misra, Ricardo A. Moreno-Rodrigue, Vincent C. Hascall, Gustavo W. Leone, Roger R. Markwald
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Cell Biology
Suniti Misra, Shibnath Ghatak, Ricardo A. Moreno-Rodriguez, Russell A. Norris, Vincent C. Hascall, Roger R. Markwald
Summary: The study reveals the crucial interaction between extracellular matrix protein periostin and cytoskeletal protein filamin A in promoting the maturation and remodeling of heart valves. This bidirectional interaction between activated FLNA and Pak1 plays a vital role in actin cytoskeletal reorganization and the differentiation of immature VICs into mature valve leaflets. Patients with specific point mutations in the filamin A gene exhibit impaired response to periostin signaling, leading to inadequate valve leaflet formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Ricardo A. Moreno-Rodriguez, Edward L. Krug, Leticia Reyes, Roger R. Markwald