Review
Biochemistry & Molecular Biology
Mei Zhang, Hong-chun Xian, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: Perineural invasion (PNI) is a common clinical feature in malignant tumors that can lead to postoperative recurrence and metastasis. Recent studies have shown that miRNA plays a crucial role in regulating PNI, offering potential new biomarkers and therapeutic targets for cancer treatment.
CELL AND BIOSCIENCE
(2021)
Review
Oncology
Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht, Vahideh Tarhriz
Summary: This review focuses on the role of exosomes in glioblastoma, highlighting their involvement in creating an immunosuppressive tumor microenvironment and their potential as therapeutic and diagnostic tools.
CANCER CELL INTERNATIONAL
(2022)
Article
Clinical Neurology
Keyi Li, Runqiu Chi, Liangjie Liu, Mofan Feng, Kai Su, Xia Li, Guang He, Yi Shi
Summary: Alzheimer's disease (AD) is a neurodegenerative disease with no effective late-stage treatment, making early prediction crucial. Recent studies have shown that miRNAs, through epigenetic modifications such as DNA methylation, play an important role in neurodegenerative diseases, including AD. Thus, miRNAs may serve as excellent biomarkers in early AD prediction.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, Research & Experimental
Ning Zhang, Xianyu Hu, Yinan Du, Juan Du
Summary: Colorectal cancer is the third most common and fourth most deadly cancer worldwide, with microRNAs playing essential roles in CRC and serving as potential targets for therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Laura Gramantieri, Catia Giovannini, Fabrizia Suzzi, Ilaria Leoni, Francesca Fornari
Summary: The heterogeneity and lack of druggable mutations in hepatocellular carcinoma (HCC) make molecular classification and personalized therapeutic treatments difficult. The absence of circulating biomarkers for treatment guidance and drug resistance in HCC remains a clinical need. Cancer stem cells (CSCs) play a crucial role in tumor heterogeneity, recurrence, and resistance, emphasizing the importance of developing novel therapeutic strategies and targets for HCC management.
Review
Chemistry, Inorganic & Nuclear
Shuai Zhang, Feilong Rong, Chuanpan Guo, Fenghe Duan, Linghao He, Minghua Wang, Zhihong Zhang, Mengmeng Kang, Miao Du
Summary: Metal-organic frameworks (MOFs) have emerged as promising porous crystalline materials with various applications due to their large surface areas, tunable pore scales, and good adsorption capabilities. They have been utilized for developing highly sensitive and selective biosensors, particularly for early cancer diagnosis and treatment monitoring, by anchoring diverse probes for construction of electrochemical biosensors.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Yaashini Rajasegaran, Adam Azlan, Aliaa Arina Rosli, Mot Yee Yik, Khor Kang Zi, Narazah Mohd Yusoff, Emmanuel Jairaj Moses
Summary: MicroRNAs play a crucial role in cancer by regulating various cancer hallmarks such as proliferation, invasion, and metastasis. Understanding the mechanisms of miRNA regulation in different cancer hallmarks can provide insights for utilizing microRNAs as biomarkers and therapeutic targets in cancer research.
Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Review
Biochemistry & Molecular Biology
Leonel Pekarek, Alicia Sanchez Cendra, Eduardo D. Roberts D. Cervantes, Cristina Sanchez Cendra, Oscar Fraile-Martinez, Cielo Garcia-Montero, Raul Diaz-Pedrero, Diego Torres-Carranza, Laura Lopez-Gonzalez, Soledad Aguado-Henche, Antonio Rios-Parra, Luis M. Garcia-Puente, Natalio Garcia-Honduvilla, Julia Bujan, Melchor Alvarez-Mon, Miguel A. Saez, Miguel A. Ortega
Summary: Breast cancer is a common malignancy in women and can either be localized or metastatic. The discovery of targeted therapies has revolutionized the prognosis for patients with metastatic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Review
Cell Biology
Ilaria Conti, Carolina Simioni, Gabriele Varano, Cinzia Brenna, Eva Costanzi, Luca Maria Neri
Summary: Advancements in cancer screening methods and treatments have increased life expectancy for cancer patients and led to a rapid growth in the community of cancer survivors. Research has highlighted the regulatory role of extracellular circulating miRNAs (ECmiRNAs) in cancer diagnosis and prognosis, suggesting their potential as biomarkers for controlling follow-up care for cancer survivors.
Article
Oncology
Sara Pizzamiglio, Giulia Cosentino, Chiara M. Ciniselli, Loris De Cecco, Alessandra Cataldo, Ilaria Plantamura, Tiziana Triulzi, Sarra El-abed, Yingbo Wang, Mohammed Bajji, Paolo Nuciforo, Jens Huober, Susan L. Ellard, David L. Rimm, Andrea Gombos, Maria Grazia Daidone, Paolo Verderio, Elda Tagliabue, Serena Di Cosimo, Marilena V. Iorio
Summary: The study evaluated the predictive and prognostic value of basal primary tumor miRNA expression profile in trastuzumab treatment and identified miRNA signatures associated with clinical outcomes. These miRNA markers have the potential to be a useful tool in identifying patients with differential responses to trastuzumab-based neoadjuvant therapy.
Review
Biochemistry & Molecular Biology
Alberto Palazzuoli, Francesco Tramonte, Matteo Beltrami
Summary: HFpEF is a poorly characterized syndrome with diverse patient profiles, various risk factors, and multiple pathophysiological pathways. Recent laboratory and metabolomic findings have revealed specific cellular and molecular mechanisms' dysregulation, allowing for early identification and new diagnostic approaches. Integrating clinical imaging, laboratory findings, and biomarkers' signature partnership can provide a precision medicine approach for prognosis and therapy.
Review
Oncology
Laura Adriana de Rooij, Dirk Jan Mastebroek, Nicky ten Voorde, Elsken van der Wall, Paul Joannes van Diest, Cathy Beatrice Moelans
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play important physiological and pathological roles. Alterations in miRNA biogenesis, target regulation, and function can promote tumor progression. Understanding the lifecycle and regulation of miRNAs is crucial for their potential application as cancer biomarkers.
Review
Biochemistry & Molecular Biology
Jelena Munjas, Miron Sopic, Aleksandra Stefanovic, Rok Kosir, Ana Ninic, Ivana Joksic, Tamara Antonic, Vesna Spasojevic-Kalimanovska, Ursula Prosenc Zmrzljak
Summary: Preeclampsia is a significant cause of maternal and neonatal morbidity and mortality worldwide, with abnormalities in lncRNAs and miRNAs in the placenta being associated with its pathophysiology. Currently, there is a lack of clinically available predictive biomarkers for Preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Valeria Bertagnolo, Silvia Grassilli, Stefano Volinia, Yasamin Al-Qassab, Federica Brugnoli, Federica Vezzali, Elisabetta Lambertini, Maria Palomba, Quirino Piubello, Enrico Orvieto, Cristina Natali, Maria Roberta Piva, Carlo Maria Croce, Silvano Capitani
MOLECULAR CARCINOGENESIS
(2019)
Article
Oncology
Matteo Fassan, Ri Cui, Pierluigi Gasparini, Claudia Mescoli, Vincenza Guzzardo, Caterina Vicentini, Giada Munari, Fotios Loupakis, Sara Lonardi, Chiara Braconi, Marco Scarpa, Edoardo D'Angelo, Salvatore Pucciarelli, Imerio Angriman, Marco Agostini, Renata D'Inca, Fabio Farinati, Roberta Gafa, Giovanni Lanza, Wendy L. Frankel, Carlo Maria Croce, Nicola Valeri, Massimo Rugge
TRANSLATIONAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan, Aldo Scarpa
BMC GASTROENTEROLOGY
(2020)
Letter
Oncology
Maria Rosaria Sapienza, Fabio Fuligni, Federica Melle, Valentina Tabanelli, Valentina Indio, Maria Antonella Laginestra, Giovanna Motta, Saveria Mazzara, Lorenzo Cerroni, Alessandro Pileri, Fabio Facchetti, Marco Paulli, Luciano Cascione, Alessandro Lagana, Emilio Berti, Manuela Ferracin, Claudio Agostinelli, Elena Sabattini, Carlo Maria Croce, Stefano Aldo Pileri
HEMATOLOGICAL ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Francesca Lovat, Pierluigi Gasparini, Giovanni Nigita, Karilyn Larkin, John C. Byrd, Mark D. Minden, Michael Andreeff, Bing Z. Carter, Carlo M. Croce
Summary: The study found that the loss of both miR-15/16 clusters may act as a potential oncogenic driver in the transition from chronic phase to blast crisis in CML patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Genetics & Heredity
Gerd A. Blobel, Douglas R. Higgs, Jennifer A. Mitchell, Dimple Notani, Richard A. Young
Summary: In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.
NATURE REVIEWS GENETICS
(2021)
Letter
Multidisciplinary Sciences
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Maria Rosaria Sapienza, Giuseppe Benvenuto, Manuela Ferracin, Saveria Mazzara, Fabio Fuligni, Claudio Tripodo, Beatrice Belmonte, Daniele Fanoni, Federica Melle, Giovanna Motta, Valentina Tabanelli, Jessica Consiglio, Vincenzo Mazzara, Marcello Del Corvo, Stefano Fiori, Alessandro Pileri, Gaetano Ivan Dellino, Lorenzo Cerroni, Fabio Facchetti, Emilio Berti, Elena Sabattini, Marco Paulli, Carlo Maria Croce, Stefano A. Pileri
Summary: This study described neuronal features in blastic plasmacytoid dendritic cell neoplasm (BPDCN) for the first time, potentially changing our understanding of the disease and leading to new strategies for treatment. The identified neural metastatic inducers in BPDCN may offer therapeutic approaches for patients. The upregulation of neural genes in BPDCN is currently being investigated as therapeutic targets.
Letter
Multidisciplinary Sciences
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Felice Pepe, Laura Z. Rassenti, Yuri Pekarsky, Jadwiga Labanowska, Tatsuya Nakamura, Giovanni Nigita, Thomas J. Kipps, Veronica Balatti, Carlo M. Croce
Summary: Chronic lymphocytic leukemia (CLL) is a common adult leukemia characterized by chromosomal aberrations. This study found that some CLL patients have undetected microdeletions, which are closely associated with chromosomal alterations in cancer. These findings may have clinical relevance for successful stratification of patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Biographical-Item
Oncology
Gary S. Stein, Carlo M. Croce
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Henry R. Kilgore, Peter G. Mikhael, Kalon J. Overholt, Ann Boija, Nancy M. Hannett, Catherine Van Dongen, Tong Ihn Lee, Young-Tae Chang, Regina Barzilay, Richard A. Young
Summary: This research reveals that different types of intracellular condensates have distinct chemical environments that affect molecular distribution. Machine learning approaches can predict the selective partitioning of molecules in condensates, providing insights for the development of small molecule therapeutics with optimal subcellular distribution and therapeutic benefits.
NATURE CHEMICAL BIOLOGY
(2023)
Meeting Abstract
Oncology
Lucia Casadei, Patricia Sarchet, Luciano Cascione, Giovanni Nigita, Fernanda Costas Casal de Faria, Carlo Maria Croce, Valerie Grignol, Raphael E. Pollock
Meeting Abstract
Oncology
Maria Rosaria Sapienza, Manuela Ferracin, Fabio Fuligni, Federica Melle, Giovanna Motta, Maria Antonella Laginestra, Maura Rossi, Luciano Cascione, Alessandro Lagana, Claudio Agostinelli, Elena Sabattini, Alessandro Pileri, Carlo Maria Croce, Stefano Aldo Pileri
