Review
Immunology
Ran Chen, Xu Zhang, Lijuan Gu, Hua Zhu, Yi Zhong, Yingze Ye, Xiaoxing Xiong, Zhihong Jian
Summary: Ischemic stroke leads to nerve cell death and immune cell activation, with immune cell infiltration having both negative and positive effects in the central nervous system, highlighting the need for further exploration of their role in cerebral ischemia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Ye, Quan Li, Chun-Shui Pan, Li Yan, Kai Sun, Xiao-Yi Wang, Shu-Qi Yao, Jing-Yu Fan, Jing-Yan Han
Summary: The study demonstrated that QiShenYiQi (QSYQ) can attenuate tPA-induced brain edema and hemorrhage by protecting blood-brain barrier integrity, partly through restoration of energy metabolism, inflammation protection, and Src/Caveolin signaling activation. QSYQ was shown to be an effective adjunctive therapy to increase the safety of delayed tPA thrombolysis for ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiang Li, Xiaoyan Tian
Summary: Pimavanserin effectively reverses neurological deficits, brain edema, increased inflammatory response, BBB permeability, and downregulation of Claudin 5 caused by cerebral ischemia injury. Its protective effects are mediated by regulating BBB integrity in a KLF6-dependent manner.
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
Xiaolong Zheng, Jun Yang, Zhou Zhu, Yongkang Fang, Yeye Tian, Minjie Xie, Wei Wang, Yang Liu
Summary: This study investigated the role of TREK-1 in focal cerebral ischemia using TREK-1-deficient mice and pharmacological inhibition. The results indicated that TREK-1 might have a detrimental effect in focal cerebral ischemia and inhibiting TREK-1 could be a strategy for treating ischemic stroke.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Juan Zhu, Zheqi Li, Zhong Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yuqin Peng, Zhenzhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan
Summary: The dynamic degradation and reconstruction of GCX may explain the biphasic changes in BBB permeability in ischemic stroke, and reveal the essential role of GCX in suppressing transcellular transport in brain endothelial cells to maintain BBB integrity. Targeting GCX may provide a novel strategy for managing BBB dysfunction and central nervous system drug delivery.
Article
Pharmacology & Pharmacy
Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L. C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang
Summary: A human IgG monoclonal antibody called L13 showed potential as a therapeutic approach for both ischemic and hemorrhagic stroke by selectively inhibiting MMP-9 activity and reducing brain tissue injury. Treatment with L13 improved neurological outcomes and attenuated BBB breakdown in mouse stroke models. The antibody also neutralized MMP-9 activity in stroke patients' sera and brain tissues, suggesting its clinical application.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Nils H. Petersen, Sreeja Kodali, Can Meng, Fangyong Li, Cindy Khanh Nguyen, Krithika U. Peshwe, Sumita Strander, Andrew Silverman, Alexandra Kimmel, Anson Wang, Mohammad Anadani, Eyad Almallouhi, Alejandro M. Spiotta, Joon-Tae Kim, James A. Giles, Salah G. Keyrouz, Mudassir Farooqui, Cynthia Zevallos, Ilko L. Maier, Marios-Nikos Psychogios, Jan Liman, Nolwenn Riou-Comte, Sebastien Richard, Benjamin Gory, Stacey Quintero Wolfe, Patrick A. Brown, Kyle M. Fargen, Eva A. Mistry, Hiba Fakhri, Akshitkumar M. Mistry, Ka-Ho Wong, Adam de Havenon, Fabio A. Nascimento, Peter Kan, Charles Matouk, Santiago Ortega-Gutierrez, Kevin N. Sheth
Summary: This study found that patients with acute ischemic stroke after EVT demonstrated distinct trajectories of blood pressure during the first 72 hours post-procedure, and these trajectories were associated with different functional outcomes. Patients with high and high-to-moderate blood pressure trajectories had a greater likelihood of an unfavorable outcome, while subjects in the high-to-moderate group had an increased risk of symptomatic intracranial hemorrhage.
Review
Nutrition & Dietetics
Edoardo Parrella, Cristina Gussago, Vanessa Porrini, Marina Benarese, Marina Pizzi
Summary: Polyphenols are a crucial family of molecules found in plants that have beneficial effects on health, potentially protecting against cancer, cardiovascular diseases, and stroke. Research indicates that polyphenols impact the cardio- and cerebrovascular systems and may also have neuroprotective effects in preclinical stroke models. Studies suggest that polyphenolic compounds could be used to aid in the recovery of stroke patients.
Review
Pharmacology & Pharmacy
Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong Ma
Summary: Stroke is a leading cause of death and survivors often suffer from severe neurological and motor deficits. The Wnt signaling pathway has been found to play a key role in the pathogenesis of stroke and reactivating this pathway can have significant therapeutic effects. A comprehensive understanding of the role of Wnt signaling in different cell types can help evaluate its potential value for stroke treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Caifeng Gu, Weichun Mo, Kunlun Wang, Mingqiang Gao, Junfeng Chen, Feng Zhang, Jie Shen
Summary: Ischemia/reperfusion (I/R) damage induced by stroke poses a serious hazard to human life, while the mechanism of blood-brain barrier (BBB) dysfunction is still unknown. Researchers found that cerebral I/R damage increased infarct volume and BBB permeability in a rat model of stroke. They also discovered that miR-370-3p regulates BBB permeability by targeting MAPK1.
Review
Biochemistry & Molecular Biology
Fulvio Tartara, Andrea Montalbetti, Emanuela Crobeddu, Daniele Armocida, Eleonora Tavazzi, Andrea Cardia, Marco Cenzato, Davide Boeris, Diego Garbossa, Fabio Cofano
Summary: This paper provides a practical review of the pathophysiological events following subarachnoid hemorrhage (SAH). The complex cascade of pathophysiological events involves various interconnected but distinct pathways. The use of heparin, with its anticoagulant effect and ability to interfere with secondary events, may be an interesting therapeutic strategy for SAH management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Review
Clinical Neurology
Pan Huang
Summary: Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot, which is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Song Ta, Xianfang Rong, Zhen-Ni Guo, Hang Jin, Peng Zhang, Fenge Li, Zhihuan Li, Lilong Lin, Chenqing Zheng, Qingquan Gu, Yuan Zhang, Wenlan Liu, Yi Yang, Junlei Chang
Summary: Variants of WNT7A and GPR124 are associated with an increased risk of parenchymal hematoma in patients with acute ischemic stroke after intravenous thrombolysis, likely through regulating the activity of canonical Wnt signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)