期刊
ADDICTION REVIEWS 2
卷 1187, 期 -, 页码 276-293出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05146.x
关键词
bipolar disorder; alcohol-related disorders; substance-related disorders; recurrence; impulsive behavior; behavioral sensitization; comorbidity
Bipolar disorder and substance-use disorders commonly occur in the same individual. In fact, bipolar disorder has a higher prevalence of substance-use disorders than any other psychiatric illness. Individuals with both disorders have a more severe course of bipolar disorder, including earlier onset, more frequent episodes, and more complications, including anxiety- and stress-related disorders, aggressive behavior, legal problems, and suicide. Bipolar and substance-use disorders share common mechanisms, including impulsivity, poor modulation of motivation and responses to rewarding stimuli, and susceptibility to behavioral sensitization. Studies of potential treatments for bipolar substance-use disorder have paid scant attention to the combined disorders. The most promising treatment strategies are those that address their shared mechanisms.
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