期刊
COOLEY'S ANEMIA: NINTH SYMPOSIUM
卷 1202, 期 -, 页码 94-99出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05573.x
关键词
nontransferrin-bound iron; fluorescent reagent
资金
- Fundacao para a Cienciae Tecnologia Lisboa Portugal [SFRH/BD/22633/2005]
The major ligands of nontransferrin-bound iron (NTBI) are suggested to be citrate and albumin. The proportion of iron binding to albumin is influenced by the degree of oxidation and glycation of the protein. LC-ICP-MS is demonstrated to be a useful technique for the speciation of NTBI, with unprocessed scrum being subjected to analysis. Ferritin iron, citrate iron, and ferrioxamine can be quantified using this technique. This review describes the use of a new fluorescent probe for NTBI quantification.
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