Article
Medicine, Research & Experimental
Dana M. Zaher, Iman M. Talaat, Amal Hussein, Mahmood Y. Hachim, Hany A. Omar
Summary: The study identified differential expression of PDH-E1A and P-PDH-E1A among breast cancer subtypes, with PDH-E1A expression suggested as a prognostic factor for the overall survival of breast cancer patients.
Review
Multidisciplinary Sciences
Dirk Roosterman, Graeme Stuart Cottrell
Summary: This article introduces two complexes in Krebs' Citric Acid Cycle, namely Citric Acid Cycle 1.1 and Citric Acid Cycle 2.1. Citric Acid Cycle 1.1 is regulated by NAD+ and involves lactate as substrate and malate as product, while Citric Acid Cycle 2.1 is regulated by FAD and involves malate as substrate and succinate or citrate as products. These complexes balance stress and accelerate ATP recovery in cells, with Citric Acid Cycle 2.1 playing a role in energy storage in white adipocytes.
Article
Critical Care Medicine
Briana K. Shimada, Liron Boyman, Weiliang Huang, Jing Zhu, Yang Yang, Fengqian Chen, Maureen A. Kane, Nagendra Yadava, Lin Zou, W. Jonathan Lederer, Brian M. Polster, Wei Chao
Summary: This study identified a broad mitochondrial protein remodeling, inactivation of pyruvate dehydrogenase (PDH), and impaired pyruvate-fueled oxidative phosphorylation during sepsis-induced cardiomyopathy. These findings provide a molecular framework for further exploration and understanding of the pathogenesis of sepsis-induced cardiomyopathy.
Article
Oncology
Xu Wang, Bing Xu, Jing Du, Jun Xia, Guojie Lei, Chaoting Zhou, Jiayu Hu, Yinhao Zhang, Sufeng Chen, Fangchun Shao, Jiyun Yang, Yanchun Li
Summary: This study investigated the role of pyruvate metabolism and citric acid cycle patterns in the tumor microenvironment of gastric cancer. The findings suggest that these patterns can predict the response to immunotherapy and may accelerate the development of immunotherapeutic strategies for gastric cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Agronomy
Tengfei Pan, Muhammad Moaaz Ali, Jiangmei Gong, Wenqin She, Dongming Pan, Zhixiong Guo, Yuan Yu, Faxing Chen
Summary: The present study measured the fruit physiology and sugar-acid ratio of 24 pomelo cultivars grown in ten different locations of the subtropical region of China. The results showed the range of basic quality attributes and sugar-acid contents of these pomelo cultivars, as well as the characteristics of some cultivars with higher citric acid and pyruvate contents.
Article
Multidisciplinary Sciences
Tugce Beyazay, Kendra S. Belthle, Christophe Fares, Martina Preiner, Joseph Moran, William F. Martin, Harun Tueysuez
Summary: Recent investigations have shown that awaruite, a Ni3Fe alloy, can efficiently catalyze the conversion of CO2 to pyruvate, acetate, and formate, suggesting its role in microbial carbon metabolism.
NATURE COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Jessica L. Lee, Cissy Zhang, Reyhan Westbrook, Mariann M. Gabrawy, Lolita Nidadavolu, Huanle Yang, Ruth Marx, Yuqiong Wu, Nicole M. Anders, Lina Ma, Marcela-Davalos Bichara, Min-Ji Kwak, Brian Buta, Mohammed Khadeer, Gayane Yenokyan, Jing Tian, Qian-Li Xue, Helmy M. Siragy, Robert M. Carey, Rafael de Cabo, Luigi Ferrucci, Ruin Moaddel, Michelle A. Rudek, Anne Le, Jeremy D. Walston, Peter M. Abadir
Summary: Losartan treatment may reduce frailty risk and improve muscle strength in older adults. Side effects include fatigue, hyperkalemia, and hypotension.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rafael Franco, Joan Serrano-Marin
Summary: The Krebs cycle in cells plays a crucial role in both energy production and anabolic processes. This study compares closed and linear metabolism and finds that the closed cycle can reach a steady state regardless of disturbances, unlike the linear metabolism. Modeling the cycle in different conditions, including cancer, reveals that reductions in flux are limited, suggesting the presence of an undiscovered regulation mechanism. The findings have important implications for evaluating metabolism-modifying medicines.
Review
Radiology, Nuclear Medicine & Medical Imaging
Yan Li, Daniel B. Vigneron, Duan Xu
Summary: Hyperpolarized carbon-13 MR metabolic imaging is crucial for acquiring real-time dynamic metabolic information and gaining insights into metabolic pathways, but faces significant challenges in broader clinical translation despite rapid development.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasmine Y. Hu, Sana Vaziri, Nikolaj Bogh, Yaewon Kim, Adam W. Autry, Robert A. Bok, Yan Li, Christoffer Laustsen, Duan Xu, Peder E. Z. Larson, Susan Chang, Daniel B. Vigneron, Jeremy W. Gordon
Summary: This study aimed to investigate the use of high-resolution hyperpolarized C-13 pyruvate MRI for measuring cerebral perfusion in the human brain. HP pyruvate MRI images were acquired and perfusion parameters were calculated and compared to arterial spin labeling results. The study found that high-resolution pyruvate images can provide measures of cerebral perfusion that are positively correlated to ASL perfusion values, indicating the potential of hyperpolarized pyruvate MRI for assessing cerebral metabolism and perfusion within the same study.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Environmental
Feitian Ran, Xiaobin Yang, Xueqing Xu, Songwei Li, Yuyan Liu, Lu Shao
Summary: By synthesizing nitrogen-doped oxygen-rich carbon nanosheets with hierarchical pores through green activation processes, this study demonstrates excellent performance in terms of high specific capacitance and superior rate capability, showcasing promising application prospects for sustainable and cost-efficient energy storage materials.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steffen Sejersen, Camilla W. Rasmussen, Nikolaj Bogh, Uffe Kjaergaard, Esben S. S. Hansen, Rolf F. Schulte, Christoffer Laustsen
Summary: This study proposes a simple method of using the (13)CO(2) content in the expired air to normalize the hyperpolarized [1-C-13]pyruvate MRI images, overcoming the non-quantitative limitation of the method for image comparison across time and individuals. Experimental results with a porcine model demonstrate that normalizing the metabolic signal using the (13)CO(2) content in expired air can significantly reduce variation in metabolic sensitive pathways and improve the specificity of the method.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Chemistry, Medicinal
Ebtehal M. Dorgham, Gamal M. El Maghraby, Ebtessam A. Essa, Mona F. Arafa
Summary: This study aimed to enhance the dissolution rate of eslicarbazepine acetate (ESL) by forming eutectic systems with tartaric acid or citric acid. The eutectic system formation with both tartaric and citric acid was confirmed, with the optimum molar ratio being 1:1 for both substances. The co-processing of ESL with either citric acid or tartaric acid resulted in significantly enhanced dissolution rate, attributed to the combined effect of eutexia and pH modification.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Kevin Wang, Amanda Moore, Cathryn Grayson, Ryan J. Mailloux
Summary: In this study, it was found that pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are important sources of hydrogen peroxide (H2O2) and key sites for redox regulation. The inhibition of KGDH by S-nitroso-glutathione (GSNO) is more sensitive compared to PDH, and the deactivation of both enzymes by nitro modification is affected by sex and diet. Overall, this study demonstrates for the first time that GSNO deactivates H2O2 production by α-keto acid dehydrogenases and shows that sex and diet are determinants for the nitro-inhibition of both KGDH and PDH.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Psychology, Clinical
Yu-Hung Chang, I-Chien Wu, Chao A. Hsiung
Summary: The study found that older adults with higher reading frequencies, especially those reading at least once a week, were less likely to experience cognitive decline, and the protective effect of reading on cognitive function was observed across all levels of education.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Geriatrics & Gerontology
Yi-Fang Lin, Yu-Chun Lin, I-Chien Wu, Yu-Hung Chang
Summary: The study found that women with secondary education were less likely to experience urinary incontinence, while individuals with severe economic hardships had an increased risk of urinary incontinence. Retired men and service workers/salespersons were more prone to urinary incontinence.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Cell Biology
Sin-Mei Guo, Yen-Tze Liu, Sin-Ru He, Ming-Shiang Wu, Wei-Ting Tseng, Ray-Chin Wu, I-Chien Wu
Summary: The study found a J-shaped association between serum uric acid and the risk of all-cause mortality in older adults, primarily for those with low grip strength. Participants with low grip strength showed a non-linear association between serum uric acid levels and mortality risk. Those with both high serum uric acid and low grip strength, or low serum uric acid and low grip strength, exhibited greater risks of mortality and deviations in biomarkers of specific systems.
Article
Psychology, Clinical
Che-Chia Chang, Chi-Shin Wu, Han-Yun Tseng, Chun-Yi Lee, I-Chien Wu, Chih-Cheng Hsu, Hsing-Yi Chang, Yen-Feng Chiu, Chao A. Hsiung
Summary: Depressive symptoms increased the risk of developing frailty among the older Asian population. The impact of late-life depressive symptoms on physical health was notable. Future policies on geriatric public health need to focus more on treatment and intervention against geriatric depressive symptoms to prevent incident frailty among older population.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Chang-Hua Chen, Ming-Shiang Wu, Yu-Wen Yang, Yen-Tze Liu, Yen-Feng Chiu, Chih-Cheng Hsu, Shu-Chun Chuang, Tieh-Chi Chung, Tsung-Lung Tsai, Wen-Hao Huang, Wei-Lin Huang, Chung-Chou Juan, Li-Ming Lien, Chao A. Hsiung, I-Chien Wu
Summary: In a cohort of elderly patients with CHB, the study demonstrated the heterogeneity and nonlinearity of HRQoL changes, and their associations with variations in specific extrahepatic organs/systems, including sarcopenic obesity, metabolic abnormalities, and depressed mood.
PREVENTIVE MEDICINE REPORTS
(2021)
Article
Genetics & Heredity
Mizuki Takaragawa, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroshi Kumagai, Hirofumi Zempo, Eri Miyamoto-Mikami, Hiroyuki Kobayashi, Hisashi Naito, Noriyuki Fuku
Summary: Human muscle fiber composition is determined by genetic factors, and a study found a potential association between a genotype score based on specific polymorphisms related to iron status and muscle fiber composition, especially in women.
Article
Cardiac & Cardiovascular Systems
Tzu-Pin Lu, Amrita Chattopadhyay, Kuan-Chen Lu, Jing-Yuan Chuang, Shih-Fan Sherri Yeh, I-Shou Chang, Ching-Yu Julius Chen, I-Chien Wu, Chih-Cheng Hsu, Tzu-Yu Chen, Wei-Ting Tseng, Chao Agnes Hsiung, Jyh-Ming Jimmy Juang
Summary: This study proposed a combined score developed using electrocardiographic parameters to predict the risk of cardiovascular mortality in the elderly population, proving to be effective in primary prevention. The ECG parameters were significantly associated with all-cause death, while the EA score showed high efficacy in predicting susceptibility to different death outcomes, demonstrating its potential for clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chih-Min Liu, Ming-En Hsieh, Yu-Feng Hu, Tzu-Yin Wei, I-Chien Wu, Pei-Fen Chen, Yenn-Jiang Lin, Satoshi Higa, Nobumori Yagi, Shih-Ann Chen, Vincent S. Tseng
Summary: An artificial intelligence (AI)-enabled model was developed for early detection and risk stratification of left ventricular hypertrophy (LVH) using 12-lead ECGs. The AI model showed improved diagnostic performance compared to cardiologists' diagnosis, and it was independently associated with higher cardiovascular or all-cause mortality. The AI model's predictive power for mortality was consistently valid among patients of different ages, sexes, and comorbidities.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Multidisciplinary Sciences
Shu-Chun Chuang, I. -Chien Wu, Jen-Jen Chang, Yi-Fen Tsai, Chiu-Wen Cheng, Yen-Feng Chiu, Hsing-Yi Chang, Marion M. Lee, Chih-Cheng Hsu, Chao Agnes Hsiung
Summary: This study investigated the association between sleep problems and cognition, finding a relationship between sleep problems and cognitive decline. Specifically, in physically robust individuals, short total sleep duration, excessive daytime sleepiness, low sleep efficiency, and insomnia complaints were associated with cognitive decline. The association was stronger for the sleep summary score.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung, Chih-Cheng Hsu
Summary: The study found that a lower leukocyte mitochondrial DNA copy number was associated with sustained higher levels of high-sensitivity C-reactive protein, and these higher levels were instantaneously associated with a higher risk of death.
Article
Geriatrics & Gerontology
Chi-Shin Wu, Han-Yun Tseng, Chun-Yi Lee, I-Chien Wu, Hsing-Yi Chang, Chih-Cheng Hsu, Chao Agnes Hsiung, Yen-Feng Chiu
Summary: This study aimed to investigate the impact of insomnia and sedative-hypnotic use on frailty in older adults. The results showed that both insomnia and sedative-hypnotic use were associated with increased frailty rates. Implementing nonpharmacological treatments to alleviate insomnia may help reduce frailty in older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Shu-Chun Chuang, I-Chien Wu, Chao Agnes Hsiung, Huei-Ting Chan, Chiu-Wen Cheng, Hui-Ling Chen, Yen-Feng Chiu, Marion M. Lee, Hsing-Yi Chang, Chih-Cheng Hsu
Summary: This study analyzed the dietary inflammatory patterns of Taiwanese individuals and evaluated their associations with biomarkers of lipid and glucose. The study found that individuals with higher scores in the inflammatory dietary pattern had higher levels of blood lipids, especially in those with abdominal obesity. These findings suggest that disease prevention strategies using dietary inflammatory patterns may vary among populations.
JOURNAL OF NUTRITION
(2023)
Article
Psychiatry
Yen-Tze Liu, Wan-Hui Wu, Wei-Ting Tseng, Hsien-Chih Lin, Ming-Shiang Wu, Pei-Fen Chen, I-Chien Wu
Summary: This study found that there is a correlation between poor glycemic control and depressive symptoms in elderly patients with type 2 diabetes. Male patients and those with higher BMI have a lower risk of depressive symptoms, while those who live alone and have ADL disability have a higher risk. The dimension of depressive affect is significantly associated with lower HbA1c levels.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Oncology
Shuo-Chen Chien, Yu-Hung Chang, Chia-Ming Yen, Ying-Erh Chen, Chia-Chun Liu, Yu-Ping Hsiao, Ping-Yen Yang, Hong-Ming Lin, Xing-Hua Lu, I-Chien Wu, Chih-Cheng Hsu, Hung-Yi Chiou, Ren-Hua Chung
Summary: Understanding the long-term care needs of cancer patients is crucial but understudied. This research uses machine learning algorithms to predict the services cancer patients may require, identifying key factors that influence these needs. The findings provide valuable insights for healthcare resource allocation and customized care interventions for cancer patients.
Review
Cardiac & Cardiovascular Systems
Cheng-Han Chan, Yu-Feng Hu, Pei-Fen Chen, I-Chien Wu, Shih-Ann Chen
Summary: This study reviews cross-sectional and cohort studies on the efficacy and feasibility of exercise tests and postural changes in diagnosing LQTS, and identifies potential issues associated with exercise tests.
ACTA CARDIOLOGICA SINICA
(2022)
