期刊
SKELETAL BIOLOGY AND MEDICINE
卷 1192, 期 -, 页码 327-329出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2009.05251.x
关键词
osteoblast; hematopoietic stem cell; Gs; bone
The heterotrimeric G protein Gs is a major mediator of the actions of several G protein-coupled receptors that target cells of the osteoblast lineage. For this reason, we generated chimeric mice with normal host cells and cells derived from embryonic stem cells missing the gene encoding the a subunit of Gs. While the mutant cells contributed to cortical osteoblasts and to hematopoietic cells in the liver, the marrow space contained few if any osteoblasts or hematopoietic cells missing Gs. Subsequent studies using the Cre-lox approach to delete Gs alpha from early cells of the osteoblast lineage and from hematopoietic stem cells were performed. These studies demonstrated the crucial roles of Gsa in osteoblastic cells in regulating the differentiation of osteoblasts and in supporting B-cell development as well as the essential role for Gsa in hematopoietic stem cells in allowing the homing of these cells to the marrow.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据