期刊
NEURONS AND NETWORKS IN THE SPINAL CORD
卷 1198, 期 -, 页码 279-293出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05534.x
关键词
cortex; spinal transection; muscle scaling; pattern generation; locomotion
资金
- NIH [NS24707, NS44564, NS54894]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044564, P01NS024707, R01NS072651, P50NS024707, R01NS040412, R01NS054894] Funding Source: NIH RePORTER
Neonatal spinalized (NST) rats can achieve autonomous weight-supported locomotion never seen after adult injury. Mechanisms that support function in NST rats include increased importance of cortical trunk control and altered biomechanical control strategies for stance and locomotion. Hind limbs are isolated from perturbations in quiet stance and act in opposition to forelimbs in locomotion in NST rats. Control of roll and yaw of the hindlimbs is crucial in their locomotion. The biomechanics of the hind limbs of NST rats are also likely crucial. We present new data showing the whole leg musculature scales proportional to normal rat musculature in NST rats, regardless of function. This scaling is a prerequisite for the NST rats to most effectively use pattern generation mechanisms and motor patterns that are similar to those present in intact rats. Pattern generation may be built into the lumbar spinal cord by evolution and matched to the limb biomechanics, so preserved muscle scaling may be essential to the NST function observed.
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